Acoustophoretic removal of proteins from blood components
| LEADER | caa a22 4500 | ||
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| 001 | 605480141 | ||
| 003 | CHVBK | ||
| 005 | 20210128100413.0 | ||
| 007 | cr unu---uuuuu | ||
| 008 | 210128e20151001xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1007/s10544-015-0003-5 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10544-015-0003-5 | ||
| 245 | 0 | 0 | |a Acoustophoretic removal of proteins from blood components |h [Elektronische Daten] |c [Maria Tenje, Maria Lundgren, Ann-Margret Swärd-Nilsson, Jens Kjeldsen-Kragh, Lena Lyxe, Andreas Lenshof] |
| 520 | 3 | |a This work presents the development of a miniaturized system for removing plasma proteins and other low-molecular-weight compounds from red blood cell (RBC) concentrate in a simple one-step-process using integrated ultrasound. The technology utilizes the principles of acoustophoresis to transfer the RBCs from the original plasma-containing solution into a protein-free SAG-M additive solution in a continuous flow process. The preparation of protein free RBC concentrate is important for blood transfusion to patients suffering from immunoglobulin A (IgA)-deficiency and developing antibodies against IgA. We show a nearly complete removal of both albumin and IgA from concentrated RBCs via this one-step-processes in samples obtained from RBC concentrate. The cell recovery of our technology is close to 97%, compared to just above 90% of the current procedure of repeated dilution and centrifugation steps. This work clearly shows the potential of integrated acoustophoresis in a miniaturized system for clinical applications. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a Acoustophoresis |2 nationallicence | |
| 690 | 7 | |a Blood component preparation |2 nationallicence | |
| 690 | 7 | |a IgA deficiency |2 nationallicence | |
| 700 | 1 | |a Tenje |D Maria |u Department of Biomedical Engineering, Lund University, Lund, Sweden |4 aut | |
| 700 | 1 | |a Lundgren |D Maria |u Department of Clinical Immunology and Transfusion Medicine, Skåne University Hospital, Lund, Sweden |4 aut | |
| 700 | 1 | |a Swärd-Nilsson |D Ann-Margret |u Department of Clinical Immunology and Transfusion Medicine, Skåne University Hospital, Lund, Sweden |4 aut | |
| 700 | 1 | |a Kjeldsen-Kragh |D Jens |u Department of Clinical Immunology and Transfusion Medicine, Skåne University Hospital, Lund, Sweden |4 aut | |
| 700 | 1 | |a Lyxe |D Lena |u Sahlgrenska University Hospital, Göteborg, Sweden |4 aut | |
| 700 | 1 | |a Lenshof |D Andreas |u Department of Biomedical Engineering, Lund University, Lund, Sweden |4 aut | |
| 773 | 0 | |t Biomedical Microdevices |d Springer US; http://www.springer-ny.com |g 17/5(2015-10-01), 1-6 |x 1387-2176 |q 17:5<1 |1 2015 |2 17 |o 10544 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10544-015-0003-5 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10544-015-0003-5 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tenje |D Maria |u Department of Biomedical Engineering, Lund University, Lund, Sweden |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lundgren |D Maria |u Department of Clinical Immunology and Transfusion Medicine, Skåne University Hospital, Lund, Sweden |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Swärd-Nilsson |D Ann-Margret |u Department of Clinical Immunology and Transfusion Medicine, Skåne University Hospital, Lund, Sweden |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kjeldsen-Kragh |D Jens |u Department of Clinical Immunology and Transfusion Medicine, Skåne University Hospital, Lund, Sweden |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lyxe |D Lena |u Sahlgrenska University Hospital, Göteborg, Sweden |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lenshof |D Andreas |u Department of Biomedical Engineering, Lund University, Lund, Sweden |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Biomedical Microdevices |d Springer US; http://www.springer-ny.com |g 17/5(2015-10-01), 1-6 |x 1387-2176 |q 17:5<1 |1 2015 |2 17 |o 10544 | ||