caa a22 4500 60548015X CHVBK 20210128100413.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10544-015-9982-5 doi (NATIONALLICENCE)springer-10.1007/s10544-015-9982-5 Novel scalable and monolithically integrated extracorporeal gas exchange device [Elektronische Daten] [Tina Rieper, Claas Müller, Holger Reinecke] A novel extracorporeal gas exchange device (EGED) is developed, implemented and characterized. The aim hereby is to overcome drawbacks of state-of-the-art devices and of state-of-science approaches, like their labor intensive fabrication and their low volume density of the gas exchange area, respectively. As a consequence of the stacked setup of alternating layers of the blood compartment and the ventilation gas compartment, the developed EGED allows for double sided gas exchange. Furthermore, it enables an adaption to the diversity of medical requirements by scaling the amount of layers. The developed fabrication chain is used to fabricate leakage-free evaluation models and allows for a transition to automated fabrication. The EGED is completely fabricated in polydimethylsiloxane (PDMS) and features diffusion membranes, which are separating the compartments, with a mean thickness of 90μm. With the evaluation models and oxygen as ventilation gas an oxygen transfer of 60ml/lblood (25ml/(minm2)) and a carbon dioxide transfer of 70ml/lblood (30ml/(minm2)) are achieved. The linear scalability of the concept as well as the functionality of the EGED with air as ventilation gas is shown. Springer Science+Business Media New York, 2015 Extracorporeal gas exchange nationallicence Silicone rubber processing nationallicence Gas transfer simulation nationallicence Large area bonding of microstructured PDMS sheets nationallicence Microstructured, thin PDMS sheets nationallicence Rieper Tina Laboratory for Process Technology, Department of Microsystems Engineering - IMTEK, University of Freiburg, Georges-Koehler-Allee 103, 79110, Freiburg, Germany aut Müller Claas Laboratory for Process Technology, Department of Microsystems Engineering - IMTEK, University of Freiburg, Georges-Koehler-Allee 103, 79110, Freiburg, Germany aut Reinecke Holger Laboratory for Process Technology, Department of Microsystems Engineering - IMTEK, University of Freiburg, Georges-Koehler-Allee 103, 79110, Freiburg, Germany aut Biomedical Microdevices Springer US; http://www.springer-ny.com 17/5(2015-10-01), 1-10 1387-2176 17:5<1 2015 17 10544 https://doi.org/10.1007/s10544-015-9982-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10544-015-9982-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rieper Tina Laboratory for Process Technology, Department of Microsystems Engineering - IMTEK, University of Freiburg, Georges-Koehler-Allee 103, 79110, Freiburg, Germany aut NATIONALLICENCE 700 1- Müller Claas Laboratory for Process Technology, Department of Microsystems Engineering - IMTEK, University of Freiburg, Georges-Koehler-Allee 103, 79110, Freiburg, Germany aut NATIONALLICENCE 700 1- Reinecke Holger Laboratory for Process Technology, Department of Microsystems Engineering - IMTEK, University of Freiburg, Georges-Koehler-Allee 103, 79110, Freiburg, Germany aut NATIONALLICENCE 773 0- Biomedical Microdevices Springer US; http://www.springer-ny.com 17/5(2015-10-01), 1-10 1387-2176 17:5<1 2015 17 10544