caa a22 4500 605480249 CHVBK 20210128100414.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10544-015-9941-1 doi (NATIONALLICENCE)springer-10.1007/s10544-015-9941-1 Fabrication and evaluation of an improved polymer-based cochlear electrode array for atraumatic insertion [Elektronische Daten] [Tae Gwon, Kyou Min, Jin Kim, Seung Oh, Ho Lee, Min-Hyun Park, Sung Kim] An atraumatic cochlear electrode array has become indispensable to high-performance cochlear implants such as electric acoustic stimulation (EAS), wherein the preservation of residual hearing is significant. For an atraumatic implantation, we propose and demonstrate a new improved design of a cochlear electrode array based on liquid crystal polymer (LCP), which can be fabricated by precise batch processes and a thermal lamination process, in contrast to conventional wire-based cochlear electrode arrays. Using a thin-film process of LCP-film-mounted silicon wafer and thermal press lamination, we devise a multi-layered structure with variable layers of LCP films to achieve a sufficient degree of basal rigidity and a flexible tip. A peripheral blind via and self-aligned silicone elastomer molding process can reduce the width of the array. Measuring the insertion and extraction forces in a human scala tympani model, we investigate five human temporal bone insertion trials and record electrically evoked auditory brainstem responses (EABR) acutely in a guinea pig model. The diameters of the finalized electrode arrays are 0.3mm (tip) and 0.75mm (base). The insertion force with a displacement of 8mm from a round window and the maximum extraction force are 2.4 mN and 34.0 mN, respectively. The electrode arrays can be inserted from 360° to 630° without trauma at the basal turn. The EABR data confirm the efficacy of the array. A new design of LCP-based cochlear electrode array for atraumatic implantation is fabricated. Verification indicates that foretells the development of an atraumatic cochlear electrode array and clinical implant. Springer Science+Business Media New York, 2015 Cochlear implantation nationallicence Intracochlear electrode array nationallicence Liquid crystal polymer nationallicence Atraumatic cochlear electrode nationallicence Polymer-based neural interface nationallicence Gwon Tae Department of Electrical and Computer Engineering, Seoul National University, Bldg. 301 Room# 1006, Seoul National University, San 56-1, 151-742, Seoul, Shillim-dong, Gwanak-gu, South Korea aut Min Kyou Department of Electrical and Computer Engineering, Seoul National University, Bldg. 301 Room# 1006, Seoul National University, San 56-1, 151-742, Seoul, Shillim-dong, Gwanak-gu, South Korea aut Kim Jin Department of Electrical and Computer Engineering, Seoul National University, Bldg. 301 Room# 1006, Seoul National University, San 56-1, 151-742, Seoul, Shillim-dong, Gwanak-gu, South Korea aut Oh Seung Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University College of Medicine, Seoul, South Korea aut Lee Ho Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University College of Medicine, Seoul, South Korea aut Park Min-Hyun Department of Otorhinolaryngology, Boramae Medical Center, SMG-SNU, Seoul, South Korea aut Kim Sung Department of Electrical and Computer Engineering, Seoul National University, Bldg. 301 Room# 1006, Seoul National University, San 56-1, 151-742, Seoul, Shillim-dong, Gwanak-gu, South Korea aut Biomedical Microdevices Springer US; http://www.springer-ny.com 17/2(2015-04-01), 1-12 1387-2176 17:2<1 2015 17 10544 https://doi.org/10.1007/s10544-015-9941-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10544-015-9941-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gwon Tae Department of Electrical and Computer Engineering, Seoul National University, Bldg. 301 Room# 1006, Seoul National University, San 56-1, 151-742, Seoul, Shillim-dong, Gwanak-gu, South Korea aut NATIONALLICENCE 700 1- Min Kyou Department of Electrical and Computer Engineering, Seoul National University, Bldg. 301 Room# 1006, Seoul National University, San 56-1, 151-742, Seoul, Shillim-dong, Gwanak-gu, South Korea aut NATIONALLICENCE 700 1- Kim Jin Department of Electrical and Computer Engineering, Seoul National University, Bldg. 301 Room# 1006, Seoul National University, San 56-1, 151-742, Seoul, Shillim-dong, Gwanak-gu, South Korea aut NATIONALLICENCE 700 1- Oh Seung Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University College of Medicine, Seoul, South Korea aut NATIONALLICENCE 700 1- Lee Ho Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University College of Medicine, Seoul, South Korea aut NATIONALLICENCE 700 1- Park Min-Hyun Department of Otorhinolaryngology, Boramae Medical Center, SMG-SNU, Seoul, South Korea aut NATIONALLICENCE 700 1- Kim Sung Department of Electrical and Computer Engineering, Seoul National University, Bldg. 301 Room# 1006, Seoul National University, San 56-1, 151-742, Seoul, Shillim-dong, Gwanak-gu, South Korea aut NATIONALLICENCE 773 0- Biomedical Microdevices Springer US; http://www.springer-ny.com 17/2(2015-04-01), 1-12 1387-2176 17:2<1 2015 17 10544