Dry-contact microelectrode membranes for wireless detection of electrical phenotypes in neonatal mouse hearts
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| 001 | 605480397 | ||
| 003 | CHVBK | ||
| 005 | 20210128100415.0 | ||
| 007 | cr unu---uuuuu | ||
| 008 | 210128e20150401xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1007/s10544-014-9912-y |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10544-014-9912-y | ||
| 245 | 0 | 0 | |a Dry-contact microelectrode membranes for wireless detection of electrical phenotypes in neonatal mouse hearts |h [Elektronische Daten] |c [Yu Zhao, Hung Cao, Tyler Beebe, Hemin Zhang, Xiaoxiao Zhang, Honglong Chang, Oscar Scremin, Ching-Ling Lien, Yu-Chong Tai, Tzung Hsiai] |
| 520 | 3 | |a Continuous monitoring of aberrant electrical rhythms during heart injury and repair requires prolonged data acquisition. We hereby developed a wearable microelectrode membrane that could be adherent to the chest of neonatal mice for in situ wireless recording of electrocardiogram (ECG) signals. The novel dry-contact membrane with a meshed parylene-C pad adjacent to the microelectrodes and the expandable meandrous strips allowed for varying size of the neonates. The performance was evaluated at the system level; specifically, the ECG signals (μV) acquired from the microelectrodes underwent two-stage amplification, band-pass filtering, and optical data transmission by an infrared Light Emitting Diode (LED) to the data-receiving unit. The circuitry was prototyped on a printed circuit board (PCB), consuming less than 300μW, and was completely powered by an inductive coupling link. Distinct P waves, QRS complexes, and T waves of ECG signals were demonstrated from the non-pharmacologically sedated neonates at ~600 beats per minutes. Thus, we demonstrate the feasibility of both real-time and wireless monitoring cardiac rhythms in a neonatal mouse (17-20mm and <1g) via dry-contact microelectrode membrane; thus, providing a basis for diagnosing aberrant electrical conduction in animal models of cardiac injury and repair. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a Neonatal mice |2 nationallicence | |
| 690 | 7 | |a Wireless monitoring |2 nationallicence | |
| 690 | 7 | |a Dry-contact electrodes |2 nationallicence | |
| 690 | 7 | |a ECG |2 nationallicence | |
| 690 | 7 | |a Heart regeneration |2 nationallicence | |
| 700 | 1 | |a Zhao |D Yu |u California Institute of Technology, Pasadena, CA, USA |4 aut | |
| 700 | 1 | |a Cao |D Hung |u Division of Cardiology, Department of Medicine, UCLA School of Medicine, 90095, Los Angeles, CA, USA |4 aut | |
| 700 | 1 | |a Beebe |D Tyler |u Department of Bioengineering, UCLA School of Engineering & Applied Sciences, 90095, Los Angeles, CA, USA |4 aut | |
| 700 | 1 | |a Zhang |D Hemin |u Northwestern Polytechnical University, Xi'an, China |4 aut | |
| 700 | 1 | |a Zhang |D Xiaoxiao |u California Institute of Technology, Pasadena, CA, USA |4 aut | |
| 700 | 1 | |a Chang |D Honglong |u Northwestern Polytechnical University, Xi'an, China |4 aut | |
| 700 | 1 | |a Scremin |D Oscar |u Research Services, Veteran Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA |4 aut | |
| 700 | 1 | |a Lien |D Ching-Ling |u Children Hospital Los Angeles, Los Angeles, CA, USA |4 aut | |
| 700 | 1 | |a Tai |D Yu-Chong |u California Institute of Technology, Pasadena, CA, USA |4 aut | |
| 700 | 1 | |a Hsiai |D Tzung |u Division of Cardiology, Department of Medicine, UCLA School of Medicine, 90095, Los Angeles, CA, USA |4 aut | |
| 773 | 0 | |t Biomedical Microdevices |d Springer US; http://www.springer-ny.com |g 17/2(2015-04-01), 1-6 |x 1387-2176 |q 17:2<1 |1 2015 |2 17 |o 10544 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10544-014-9912-y |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10544-014-9912-y |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zhao |D Yu |u California Institute of Technology, Pasadena, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Cao |D Hung |u Division of Cardiology, Department of Medicine, UCLA School of Medicine, 90095, Los Angeles, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Beebe |D Tyler |u Department of Bioengineering, UCLA School of Engineering & Applied Sciences, 90095, Los Angeles, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zhang |D Hemin |u Northwestern Polytechnical University, Xi'an, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zhang |D Xiaoxiao |u California Institute of Technology, Pasadena, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Chang |D Honglong |u Northwestern Polytechnical University, Xi'an, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Scremin |D Oscar |u Research Services, Veteran Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lien |D Ching-Ling |u Children Hospital Los Angeles, Los Angeles, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tai |D Yu-Chong |u California Institute of Technology, Pasadena, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hsiai |D Tzung |u Division of Cardiology, Department of Medicine, UCLA School of Medicine, 90095, Los Angeles, CA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Biomedical Microdevices |d Springer US; http://www.springer-ny.com |g 17/2(2015-04-01), 1-6 |x 1387-2176 |q 17:2<1 |1 2015 |2 17 |o 10544 | ||