caa a22 4500 605480397 CHVBK 20210128100415.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10544-014-9912-y doi (NATIONALLICENCE)springer-10.1007/s10544-014-9912-y Dry-contact microelectrode membranes for wireless detection of electrical phenotypes in neonatal mouse hearts [Elektronische Daten] [Yu Zhao, Hung Cao, Tyler Beebe, Hemin Zhang, Xiaoxiao Zhang, Honglong Chang, Oscar Scremin, Ching-Ling Lien, Yu-Chong Tai, Tzung Hsiai] Continuous monitoring of aberrant electrical rhythms during heart injury and repair requires prolonged data acquisition. We hereby developed a wearable microelectrode membrane that could be adherent to the chest of neonatal mice for in situ wireless recording of electrocardiogram (ECG) signals. The novel dry-contact membrane with a meshed parylene-C pad adjacent to the microelectrodes and the expandable meandrous strips allowed for varying size of the neonates. The performance was evaluated at the system level; specifically, the ECG signals (μV) acquired from the microelectrodes underwent two-stage amplification, band-pass filtering, and optical data transmission by an infrared Light Emitting Diode (LED) to the data-receiving unit. The circuitry was prototyped on a printed circuit board (PCB), consuming less than 300μW, and was completely powered by an inductive coupling link. Distinct P waves, QRS complexes, and T waves of ECG signals were demonstrated from the non-pharmacologically sedated neonates at ~600 beats per minutes. Thus, we demonstrate the feasibility of both real-time and wireless monitoring cardiac rhythms in a neonatal mouse (17-20mm and <1g) via dry-contact microelectrode membrane; thus, providing a basis for diagnosing aberrant electrical conduction in animal models of cardiac injury and repair. Springer Science+Business Media New York, 2015 Neonatal mice nationallicence Wireless monitoring nationallicence Dry-contact electrodes nationallicence ECG nationallicence Heart regeneration nationallicence Zhao Yu California Institute of Technology, Pasadena, CA, USA aut Cao Hung Division of Cardiology, Department of Medicine, UCLA School of Medicine, 90095, Los Angeles, CA, USA aut Beebe Tyler Department of Bioengineering, UCLA School of Engineering & Applied Sciences, 90095, Los Angeles, CA, USA aut Zhang Hemin Northwestern Polytechnical University, Xi'an, China aut Zhang Xiaoxiao California Institute of Technology, Pasadena, CA, USA aut Chang Honglong Northwestern Polytechnical University, Xi'an, China aut Scremin Oscar Research Services, Veteran Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA aut Lien Ching-Ling Children Hospital Los Angeles, Los Angeles, CA, USA aut Tai Yu-Chong California Institute of Technology, Pasadena, CA, USA aut Hsiai Tzung Division of Cardiology, Department of Medicine, UCLA School of Medicine, 90095, Los Angeles, CA, USA aut Biomedical Microdevices Springer US; http://www.springer-ny.com 17/2(2015-04-01), 1-6 1387-2176 17:2<1 2015 17 10544 https://doi.org/10.1007/s10544-014-9912-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10544-014-9912-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhao Yu California Institute of Technology, Pasadena, CA, USA aut NATIONALLICENCE 700 1- Cao Hung Division of Cardiology, Department of Medicine, UCLA School of Medicine, 90095, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Beebe Tyler Department of Bioengineering, UCLA School of Engineering & Applied Sciences, 90095, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Zhang Hemin Northwestern Polytechnical University, Xi'an, China aut NATIONALLICENCE 700 1- Zhang Xiaoxiao California Institute of Technology, Pasadena, CA, USA aut NATIONALLICENCE 700 1- Chang Honglong Northwestern Polytechnical University, Xi'an, China aut NATIONALLICENCE 700 1- Scremin Oscar Research Services, Veteran Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Lien Ching-Ling Children Hospital Los Angeles, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Tai Yu-Chong California Institute of Technology, Pasadena, CA, USA aut NATIONALLICENCE 700 1- Hsiai Tzung Division of Cardiology, Department of Medicine, UCLA School of Medicine, 90095, Los Angeles, CA, USA aut NATIONALLICENCE 773 0- Biomedical Microdevices Springer US; http://www.springer-ny.com 17/2(2015-04-01), 1-6 1387-2176 17:2<1 2015 17 10544