Amphiphilic alginate as a drug release vehicle for water-insoluble drugs
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| 024 | 7 | 0 | |a 10.1134/S1061933X15060149 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1134/S1061933X15060149 | ||
| 245 | 0 | 0 | |a Amphiphilic alginate as a drug release vehicle for water-insoluble drugs |h [Elektronische Daten] |c [Yang Meng, Chenyu Wu, Jiaxing Zhang, Qimeng Cao, Qingbing Liu, Yueqin Yu] |
| 520 | 3 | |a A preliminary study on the hydrophobic modified alginate (HM-alginate) as the drug delivery system for the model water-insoluble drugs, clofazimine and Amphotericin B was performed. It was found that HM-alginate can significantly increase the solubilities of these two drugs. The apparent water solubilities of clofazimine and Amphotericin B increased up to 1100 and 160 times, respectively, in aqueous solutions containing HM-alginate. The presence of sodium chloride in polymer solution decreased the solubilities of the drugs, compared to the salt-free solutions. HM-alginate also exhibited excellent sustained release effect, which increased with concentration. The type of HM-alginate, which we used herein, might have potential applications as water-insoluble drug delivery carrier. | |
| 540 | |a Pleiades Publishing, Ltd., 2015 | ||
| 700 | 1 | |a Meng |D Yang |u State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, 266042, Qingdao, P. R. China |4 aut | |
| 700 | 1 | |a Wu |D Chenyu |u College of Materials Science and Engineering, Chongqing University, 400044, Chongqing, P. R. China |4 aut | |
| 700 | 1 | |a Zhang |D Jiaxing |u State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, 266042, Qingdao, P. R. China |4 aut | |
| 700 | 1 | |a Cao |D Qimeng |u State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, 266042, Qingdao, P. R. China |4 aut | |
| 700 | 1 | |a Liu |D Qingbing |u State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, 266042, Qingdao, P. R. China |4 aut | |
| 700 | 1 | |a Yu |D Yueqin |u State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, 266042, Qingdao, P. R. China |4 aut | |
| 773 | 0 | |t Colloid Journal |d Pleiades Publishing |g 77/6(2015-11-01), 754-760 |x 1061-933X |q 77:6<754 |1 2015 |2 77 |o 10595 | |
| 856 | 4 | 0 | |u https://doi.org/10.1134/S1061933X15060149 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1134/S1061933X15060149 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Meng |D Yang |u State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, 266042, Qingdao, P. R. China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Wu |D Chenyu |u College of Materials Science and Engineering, Chongqing University, 400044, Chongqing, P. R. China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zhang |D Jiaxing |u State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, 266042, Qingdao, P. R. China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Cao |D Qimeng |u State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, 266042, Qingdao, P. R. China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Liu |D Qingbing |u State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, 266042, Qingdao, P. R. China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yu |D Yueqin |u State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, 266042, Qingdao, P. R. China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Colloid Journal |d Pleiades Publishing |g 77/6(2015-11-01), 754-760 |x 1061-933X |q 77:6<754 |1 2015 |2 77 |o 10595 | ||