caa a22 4500 605489386 CHVBK 20210128100459.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1134/S1061933X15060149 doi (NATIONALLICENCE)springer-10.1134/S1061933X15060149 Amphiphilic alginate as a drug release vehicle for water-insoluble drugs [Elektronische Daten] [Yang Meng, Chenyu Wu, Jiaxing Zhang, Qimeng Cao, Qingbing Liu, Yueqin Yu] A preliminary study on the hydrophobic modified alginate (HM-alginate) as the drug delivery system for the model water-insoluble drugs, clofazimine and Amphotericin B was performed. It was found that HM-alginate can significantly increase the solubilities of these two drugs. The apparent water solubilities of clofazimine and Amphotericin B increased up to 1100 and 160 times, respectively, in aqueous solutions containing HM-alginate. The presence of sodium chloride in polymer solution decreased the solubilities of the drugs, compared to the salt-free solutions. HM-alginate also exhibited excellent sustained release effect, which increased with concentration. The type of HM-alginate, which we used herein, might have potential applications as water-insoluble drug delivery carrier. Pleiades Publishing, Ltd., 2015 Meng Yang State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, 266042, Qingdao, P. R. China aut Wu Chenyu College of Materials Science and Engineering, Chongqing University, 400044, Chongqing, P. R. China aut Zhang Jiaxing State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, 266042, Qingdao, P. R. China aut Cao Qimeng State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, 266042, Qingdao, P. R. China aut Liu Qingbing State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, 266042, Qingdao, P. R. China aut Yu Yueqin State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, 266042, Qingdao, P. R. China aut Colloid Journal Pleiades Publishing 77/6(2015-11-01), 754-760 1061-933X 77:6<754 2015 77 10595 https://doi.org/10.1134/S1061933X15060149 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1134/S1061933X15060149 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Meng Yang State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, 266042, Qingdao, P. R. China aut NATIONALLICENCE 700 1- Wu Chenyu College of Materials Science and Engineering, Chongqing University, 400044, Chongqing, P. R. China aut NATIONALLICENCE 700 1- Zhang Jiaxing State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, 266042, Qingdao, P. R. China aut NATIONALLICENCE 700 1- Cao Qimeng State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, 266042, Qingdao, P. R. China aut NATIONALLICENCE 700 1- Liu Qingbing State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, 266042, Qingdao, P. R. China aut NATIONALLICENCE 700 1- Yu Yueqin State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, 266042, Qingdao, P. R. China aut NATIONALLICENCE 773 0- Colloid Journal Pleiades Publishing 77/6(2015-11-01), 754-760 1061-933X 77:6<754 2015 77 10595