caa a22 4500 605489742 CHVBK 20210128100501.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1134/S1061933X15040158 doi (NATIONALLICENCE)springer-10.1134/S1061933X15040158 Study of phospholipid-induced phase-separation in amphiphilic drugs [Elektronische Daten] [Andleeb Naqvi, Malik Rub, Kabir-ud Din] Phase separation of five amphiphilic drugs in 10 mM phosphate buffer with added phospholipids has been studied. The drugs used are tricyclic antidepressants (amitriptyline hydrochloride, imipramine hydrochloride, and clomipramine hydrochloride) and phenothiazines (promethazine hydrochloride and promazine hydrochloride). Depending on the nature and structure of studied compounds, the phospholipids caused different effects on the clouding behavior. Cardiolipin decreased the cloud point for all drugs. With amitriptyline, all the additives lowered the cloud points, whereas the clomipramine showed opposite tendency. Imipramine and promethazine led to similar extremal behaviour of cloud point, although promazine, which is structurally similar to promethazine, did not show the same tendency. Thermodynamic analysis of the experimental data suggested that the process of clouding is entropically driven. Pleiades Publishing, Ltd., 2015 Naqvi Andleeb Chemistry Department, King Abdulaziz University, 21589, Jeddah, Saudi Arabia aut Rub Malik Chemistry Department, King Abdulaziz University, 21589, Jeddah, Saudi Arabia aut Din Kabir-ud Chemistry Department, King Abdulaziz University, 21589, Jeddah, Saudi Arabia aut Colloid Journal Pleiades Publishing 77/4(2015-07-01), 525-531 1061-933X 77:4<525 2015 77 10595 https://doi.org/10.1134/S1061933X15040158 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1134/S1061933X15040158 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Naqvi Andleeb Chemistry Department, King Abdulaziz University, 21589, Jeddah, Saudi Arabia aut NATIONALLICENCE 700 1- Rub Malik Chemistry Department, King Abdulaziz University, 21589, Jeddah, Saudi Arabia aut NATIONALLICENCE 700 1- Din Kabir-ud Chemistry Department, King Abdulaziz University, 21589, Jeddah, Saudi Arabia aut NATIONALLICENCE 773 0- Colloid Journal Pleiades Publishing 77/4(2015-07-01), 525-531 1061-933X 77:4<525 2015 77 10595