Role of sentinel lymph node biopsy in patients with Merkel cell carcinoma: statistical analysis of 403 reported cases
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| 024 | 7 | 0 | |a 10.1007/s10147-014-0685-3 |2 doi |
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| 245 | 0 | 0 | |a Role of sentinel lymph node biopsy in patients with Merkel cell carcinoma: statistical analysis of 403 reported cases |h [Elektronische Daten] |c [Yoshitsugu Shibayama, Shinichi Imafuku, Akira Takahashi, Juichiro Nakayama] |
| 520 | 3 | |a Background: Merkel cell carcinoma (MCC) is a rare cutaneous malignancy with a high rate of nodal metastasis. Sentinel lymph node biopsy (SLNB) is used in MCC and other cancers to identify regional node micrometastases in patients with clinically negative nodes; however, whether SLN status is associated with recurrence or prognosis in MCC is unclear. Methods: A statistical analysis was performed of 397 published cases of MCC with SLNB results from 22 reports and 6 new cases, in order to elucidate any correlation between SLN status and recurrence, and to determine false-negative rates for SLNB. Results: Of these 403 cases, 128 (31.8%) had positive SLNs; 16 of these 128 (12.5%) developed recurrence (6 nodal, 10 distant). Of 275 patients with negative SLNs, 27 (9.8%) developed recurrence (19 nodal, 8 distant). Patients with positive SLNs had a greater risk of distant metastasis (OR 2.82; P=0.037; 95% CI 1.089-7.347). The false-negative rate for SLNB in all 403 patients was 12.9%. Use of the immunohistochemical approach to diagnosis of micrometastasis with anti-CK20 antibody did not affect the false-negative rate. Conclusions: Patients with positive SLNs had a greater risk of distant metastasis in MCC; positive SLN was an important prognostic factor in MCC. Further studies using standardized, more-sensitive techniques to examine entire SLNs may decrease the false-negative rate, and improve the significance of SLNB in MCC. | |
| 540 | |a Japan Society of Clinical Oncology, 2014 | ||
| 690 | 7 | |a Merkel cell carcinoma |2 nationallicence | |
| 690 | 7 | |a Sentinel lymph node |2 nationallicence | |
| 690 | 7 | |a False negative |2 nationallicence | |
| 690 | 7 | |a Recurrence |2 nationallicence | |
| 690 | 7 | |a Meta-analysis |2 nationallicence | |
| 700 | 1 | |a Shibayama |D Yoshitsugu |u Department of Dermatology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, 814-0133, Fukuoka, Japan |4 aut | |
| 700 | 1 | |a Imafuku |D Shinichi |u Department of Dermatology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, 814-0133, Fukuoka, Japan |4 aut | |
| 700 | 1 | |a Takahashi |D Akira |u Department of Dermatology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, 814-0133, Fukuoka, Japan |4 aut | |
| 700 | 1 | |a Nakayama |D Juichiro |u Department of Dermatology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, 814-0133, Fukuoka, Japan |4 aut | |
| 773 | 0 | |t International Journal of Clinical Oncology |d Springer Japan |g 20/1(2015-02-01), 188-193 |x 1341-9625 |q 20:1<188 |1 2015 |2 20 |o 10147 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10147-014-0685-3 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10147-014-0685-3 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Shibayama |D Yoshitsugu |u Department of Dermatology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, 814-0133, Fukuoka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Imafuku |D Shinichi |u Department of Dermatology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, 814-0133, Fukuoka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Takahashi |D Akira |u Department of Dermatology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, 814-0133, Fukuoka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nakayama |D Juichiro |u Department of Dermatology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, 814-0133, Fukuoka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t International Journal of Clinical Oncology |d Springer Japan |g 20/1(2015-02-01), 188-193 |x 1341-9625 |q 20:1<188 |1 2015 |2 20 |o 10147 | ||