caa a22 4500 605490309 CHVBK 20210128100504.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s10147-014-0679-1 doi (NATIONALLICENCE)springer-10.1007/s10147-014-0679-1 Radiotherapy for thoracic tumors: association between subclinical interstitial lung disease and fatal radiation pneumonitis [Elektronische Daten] [Shinsaku Yamaguchi, Takayuki Ohguri, Yuichi Matsuki, Katsuya Yahara, Hodaka Oki, Hajime Imada, Hiroyuki Narisada, Yukunori Korogi] Background: We evaluated the association between subclinical interstitial lung disease (ILD) and fatal radiation pneumonitis (RP) in patients with thoracic tumors treated with thoracic radiotherapy (RT). Methods: Sixty-two consecutive patients with thoracic tumors treated with thoracic RT were retrospectively analyzed. According to our protocols, patients with subclinical ILD (untreated and asymptomatic) were considered to be indicated for thoracic RT, while patients with clinical ILD (post- or during treatment) were not considered candidates for thoracic RT. The presence, extent and distribution of subclinical ILD on CT findings at pre-thoracic RT were reviewed and scored by two chest radiologists. The relationships between RP and clinical factors, including subclinical ILD, were investigated. Results: Subclinical ILD was recognized in 11 (18%) of the 62 patients. Grade 2-5 RP was recognized in eight (13%) of the 62 patients, with Grade 5 in three patients and Grade 2 in five patients. Grade 2-5 RP was observed in four (36%) of the 11 patients with subclinical ILD. Subclinical ILD was found to be a significant factor influencing the development of Grade 2-5 RP (p=0.0274). Subclinical ILD tended to be significant for the occurrence of Grade 5 RP (p=0.0785). Regarding the CT score, more extensive ILD (bilateral fibrosis in multiple lobes) was recognized in two of the three patients with Grade 5 RP. Conclusions: In this study, fatal RP tended to be more common in the patients with subclinical ILD. In particular, the presence of extensive fibrosis on CT may be a contraindication for thoracic RT. Japan Society of Clinical Oncology, 2014 Thoracic radiotherapy nationallicence Interstitial lung disease nationallicence Radiation pneumonitis nationallicence Yamaguchi Shinsaku Department of Radiology, Kitakyushu General Hospital, Kitakyushu, Japan aut Ohguri Takayuki Department of Radiology, University of Occupational and Environmental Health, Iseigaoka 1-1, Yahatanishi-ku, 807-8555, Kitakyushu, Japan aut Matsuki Yuichi Department of Radiology, Kitakyushu General Hospital, Kitakyushu, Japan aut Yahara Katsuya Department of Radiology, University of Occupational and Environmental Health, Iseigaoka 1-1, Yahatanishi-ku, 807-8555, Kitakyushu, Japan aut Oki Hodaka Department of Radiology, University of Occupational and Environmental Health, Iseigaoka 1-1, Yahatanishi-ku, 807-8555, Kitakyushu, Japan aut Imada Hajime Department of Cancer Therapy Center, Tobata Kyoritsu Hospital, Kitakyushu, Japan aut Narisada Hiroyuki Department of Cancer Therapy Center, Tobata Kyoritsu Hospital, Kitakyushu, Japan aut Korogi Yukunori Department of Radiology, University of Occupational and Environmental Health, Iseigaoka 1-1, Yahatanishi-ku, 807-8555, Kitakyushu, Japan aut International Journal of Clinical Oncology Springer Japan 20/1(2015-02-01), 45-52 1341-9625 20:1<45 2015 20 10147 https://doi.org/10.1007/s10147-014-0679-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10147-014-0679-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yamaguchi Shinsaku Department of Radiology, Kitakyushu General Hospital, Kitakyushu, Japan aut NATIONALLICENCE 700 1- Ohguri Takayuki Department of Radiology, University of Occupational and Environmental Health, Iseigaoka 1-1, Yahatanishi-ku, 807-8555, Kitakyushu, Japan aut NATIONALLICENCE 700 1- Matsuki Yuichi Department of Radiology, Kitakyushu General Hospital, Kitakyushu, Japan aut NATIONALLICENCE 700 1- Yahara Katsuya Department of Radiology, University of Occupational and Environmental Health, Iseigaoka 1-1, Yahatanishi-ku, 807-8555, Kitakyushu, Japan aut NATIONALLICENCE 700 1- Oki Hodaka Department of Radiology, University of Occupational and Environmental Health, Iseigaoka 1-1, Yahatanishi-ku, 807-8555, Kitakyushu, Japan aut NATIONALLICENCE 700 1- Imada Hajime Department of Cancer Therapy Center, Tobata Kyoritsu Hospital, Kitakyushu, Japan aut NATIONALLICENCE 700 1- Narisada Hiroyuki Department of Cancer Therapy Center, Tobata Kyoritsu Hospital, Kitakyushu, Japan aut NATIONALLICENCE 700 1- Korogi Yukunori Department of Radiology, University of Occupational and Environmental Health, Iseigaoka 1-1, Yahatanishi-ku, 807-8555, Kitakyushu, Japan aut NATIONALLICENCE 773 0- International Journal of Clinical Oncology Springer Japan 20/1(2015-02-01), 45-52 1341-9625 20:1<45 2015 20 10147