Preoperative risk stratification for cancer-specific survival of patients with upper urinary tract urothelial carcinoma treated by nephroureterectomy
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| 024 | 7 | 0 | |a 10.1007/s10147-014-0695-1 |2 doi |
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| 245 | 0 | 0 | |a Preoperative risk stratification for cancer-specific survival of patients with upper urinary tract urothelial carcinoma treated by nephroureterectomy |h [Elektronische Daten] |c [Kazutoshi Fujita, Motohide Uemura, Yoshiyuki Yamamoto, Go Tanigawa, Wataru Nakata, Mototaka Sato, Akira Nagahara, Hiroshi Kiuchi, Yasutomo Nakai, Kiyomi Matsumiya, Seiji Yamaguchi, Norio Nonomura] |
| 520 | 3 | |a Background: This study aimed to identify preoperative parameters for predicting cancer-specific survival (CSS) in patients with upper urinary tract urothelial carcinoma (UTUC) who have undergone radical nephroureterectomy (RNU). Methods: The preoperative clinical and laboratory records of 357 UTUC patients who underwent RNU at three different institutions were retrospectively reviewed (256, training set; 101, test set). Univariate and multivariate analyses were performed on the training set data to identify preoperative prognostic factors, using which a risk stratification model was developed. The model was validated using test set data. Results: In univariate analysis, clinical T stage classification and preoperative concentrations of hemoglobin, C-reactive protein, sodium, and albumin showed significant association with CSS. Multivariate analysis showed that low preoperative sodium and hemoglobin concentrations were significantly associated with a poor prognosis. A risk stratification model was developed using the preoperative sodium (<141mEq/L) and hemoglobin concentrations (below normal). Three subgroups were formed depending on the presence of no (favorable group), one (intermediate), or two (poor) prognostic factors, and the 5-year CSS estimates were found to be 96.5, 75.5, and 47.0%, respectively (P<0.01). The risk model was significantly associated with the adverse pathological findings of stage pT3 or more and lymphovascular invasion (P=0.005). Conclusion: We identified low preoperative sodium and hemoglobin concentrations as prognostic factors for patients with UTUC treated with RNU. Our risk stratification model may help physicians design a therapeutic strategy. | |
| 540 | |a Japan Society of Clinical Oncology, 2014 | ||
| 690 | 7 | |a Prognosis |2 nationallicence | |
| 690 | 7 | |a Upper urinary tract urothelial carcinoma |2 nationallicence | |
| 690 | 7 | |a Nephroureterectomy |2 nationallicence | |
| 690 | 7 | |a Sodium |2 nationallicence | |
| 690 | 7 | |a Hemoglobin |2 nationallicence | |
| 700 | 1 | |a Fujita |D Kazutoshi |u Department of Urology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, 565-0871, Suita, Osaka, Japan |4 aut | |
| 700 | 1 | |a Uemura |D Motohide |u Department of Urology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, 565-0871, Suita, Osaka, Japan |4 aut | |
| 700 | 1 | |a Yamamoto |D Yoshiyuki |u Department of Urology, Osaka Police Hospital, Osaka, Japan |4 aut | |
| 700 | 1 | |a Tanigawa |D Go |u Department of Urology, Osaka General Medical Center, Osaka, Japan |4 aut | |
| 700 | 1 | |a Nakata |D Wataru |u Department of Urology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, 565-0871, Suita, Osaka, Japan |4 aut | |
| 700 | 1 | |a Sato |D Mototaka |u Department of Urology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, 565-0871, Suita, Osaka, Japan |4 aut | |
| 700 | 1 | |a Nagahara |D Akira |u Department of Urology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, 565-0871, Suita, Osaka, Japan |4 aut | |
| 700 | 1 | |a Kiuchi |D Hiroshi |u Department of Urology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, 565-0871, Suita, Osaka, Japan |4 aut | |
| 700 | 1 | |a Nakai |D Yasutomo |u Department of Urology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, 565-0871, Suita, Osaka, Japan |4 aut | |
| 700 | 1 | |a Matsumiya |D Kiyomi |u Department of Urology, Osaka Police Hospital, Osaka, Japan |4 aut | |
| 700 | 1 | |a Yamaguchi |D Seiji |u Department of Urology, Osaka General Medical Center, Osaka, Japan |4 aut | |
| 700 | 1 | |a Nonomura |D Norio |u Department of Urology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, 565-0871, Suita, Osaka, Japan |4 aut | |
| 773 | 0 | |t International Journal of Clinical Oncology |d Springer Japan |g 20/1(2015-02-01), 156-163 |x 1341-9625 |q 20:1<156 |1 2015 |2 20 |o 10147 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10147-014-0695-1 |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10147-014-0695-1 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Fujita |D Kazutoshi |u Department of Urology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, 565-0871, Suita, Osaka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Uemura |D Motohide |u Department of Urology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, 565-0871, Suita, Osaka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yamamoto |D Yoshiyuki |u Department of Urology, Osaka Police Hospital, Osaka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tanigawa |D Go |u Department of Urology, Osaka General Medical Center, Osaka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nakata |D Wataru |u Department of Urology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, 565-0871, Suita, Osaka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sato |D Mototaka |u Department of Urology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, 565-0871, Suita, Osaka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nagahara |D Akira |u Department of Urology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, 565-0871, Suita, Osaka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kiuchi |D Hiroshi |u Department of Urology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, 565-0871, Suita, Osaka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nakai |D Yasutomo |u Department of Urology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, 565-0871, Suita, Osaka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Matsumiya |D Kiyomi |u Department of Urology, Osaka Police Hospital, Osaka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yamaguchi |D Seiji |u Department of Urology, Osaka General Medical Center, Osaka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nonomura |D Norio |u Department of Urology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, 565-0871, Suita, Osaka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t International Journal of Clinical Oncology |d Springer Japan |g 20/1(2015-02-01), 156-163 |x 1341-9625 |q 20:1<156 |1 2015 |2 20 |o 10147 | ||