Phase II study of first-line chemotherapy with uracil-tegafur plus oral leucovorin in elderly (≥75years) Japanese patients with metastatic colorectal cancer: SGOSG-CR0501 study
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| 024 | 7 | 0 | |a 10.1007/s10147-014-0675-5 |2 doi |
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| 245 | 0 | 0 | |a Phase II study of first-line chemotherapy with uracil-tegafur plus oral leucovorin in elderly (≥75years) Japanese patients with metastatic colorectal cancer: SGOSG-CR0501 study |h [Elektronische Daten] |c [Toshihiko Matsumoto, Tomohiro Nishina, Minoru Mizuta, Akihito Tsuji, Ryouhei Watanabe, Ikuo Takahashi, Yuji Watanabe, Toshikazu Moriwaki, Takashi Maeba, Ichinosuke Hyodo] |
| 520 | 3 | |a Background: Oral uracil-tegafur and leucovorin (UFT/LV) therapy for elderly patients with metastatic colorectal cancer (mCRC) requires careful handling in Western countries because of a high incidence (≥20%) of grade 3 diarrhea. However, its efficacy and safety for elderly Asian patients have not been investigated. Methods: In this multicenter cooperative phase II study, the eligibility criteria were: age of 75years or older, no prior chemotherapy, and histologically confirmed colorectal cancer with one or more measurable lesions. UFT 300mg/m2/day and LV 75mg/day were administered orally for 28days followed by a 7-day rest period. Results: Twenty-one patients were enrolled in this study (prior to study termination after approval of bevacizumab), and all patients were eligible for efficacy and safety analysis. The median age was 79years (range, 75-83years). The majority of patients (95%) had ECOG Performance Status 0 or 1. The overall response rate was 33% (95% confidence interval [CI], 18-53%). The median progression-free and overall survivals were 5.3months (95% CI 4.0-7.9months) and 18months (95% CI 13-21months), respectively. Grade 3 or greater adverse events included anorexia (10%), diarrhea (10%), and leukopenia (5%). These results were compatible with those seen in Japanese patients in a previous bridging study between Japan and the US, in which patients under 75years old were evaluated. Conclusions: UFT/LV therapy was safe and feasible in elderly Japanese patients with mCRC, and further study of UFT/LV therapy in combination with bevacizumab is warranted. | |
| 540 | |a Japan Society of Clinical Oncology, 2014 | ||
| 690 | 7 | |a Chemotherapy |2 nationallicence | |
| 690 | 7 | |a Elderly patients |2 nationallicence | |
| 690 | 7 | |a UFT |2 nationallicence | |
| 690 | 7 | |a Metastatic colorectal cancer |2 nationallicence | |
| 700 | 1 | |a Matsumoto |D Toshihiko |u Department of Gastrointestinal Medical Oncology, National Hospital Organization Shikoku Cancer Center, Kou 160, Minamiumemotomachi, 791-0280, Matsuyama, Ehime, Japan |4 aut | |
| 700 | 1 | |a Nishina |D Tomohiro |u Department of Gastrointestinal Medical Oncology, National Hospital Organization Shikoku Cancer Center, Kou 160, Minamiumemotomachi, 791-0280, Matsuyama, Ehime, Japan |4 aut | |
| 700 | 1 | |a Mizuta |D Minoru |u Mitoyo General Hospital, Himehama, Toyohama-cho, 769-1695, Kanonji, Kagawa, Japan |4 aut | |
| 700 | 1 | |a Tsuji |D Akihito |u Kochi Health Sciences Center, Ike, 781-8555, Kochi, Kochi, Japan |4 aut | |
| 700 | 1 | |a Watanabe |D Ryouhei |u Matsuyama-shimin Hospital, Ootemachi, 790-0067, Matsuyama, Ehime, Japan |4 aut | |
| 700 | 1 | |a Takahashi |D Ikuo |u Matsuyama Red Cross Hospital, Bunkyo-cho, 790-8524, Matsuyama, Ehime, Japan |4 aut | |
| 700 | 1 | |a Watanabe |D Yuji |u Ehime University School of Medicine, Shitsukawa, 791-0295, Toon, Ehime, Japan |4 aut | |
| 700 | 1 | |a Moriwaki |D Toshikazu |u University of Tsukuba, Tennodai, 305-0006, Tsukuba, Ibaraki, Japan |4 aut | |
| 700 | 1 | |a Maeba |D Takashi |u Social Insurance Ritsurin Hospital, Ritsurin-cho, 760-007, Takamatsu, Kagawa, Japan |4 aut | |
| 700 | 1 | |a Hyodo |D Ichinosuke |u University of Tsukuba, Tennodai, 305-0006, Tsukuba, Ibaraki, Japan |4 aut | |
| 773 | 0 | |t International Journal of Clinical Oncology |d Springer Japan |g 20/1(2015-02-01), 111-116 |x 1341-9625 |q 20:1<111 |1 2015 |2 20 |o 10147 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10147-014-0675-5 |q text/html |z Onlinezugriff via DOI |
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10147-014-0675-5 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Matsumoto |D Toshihiko |u Department of Gastrointestinal Medical Oncology, National Hospital Organization Shikoku Cancer Center, Kou 160, Minamiumemotomachi, 791-0280, Matsuyama, Ehime, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nishina |D Tomohiro |u Department of Gastrointestinal Medical Oncology, National Hospital Organization Shikoku Cancer Center, Kou 160, Minamiumemotomachi, 791-0280, Matsuyama, Ehime, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Mizuta |D Minoru |u Mitoyo General Hospital, Himehama, Toyohama-cho, 769-1695, Kanonji, Kagawa, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tsuji |D Akihito |u Kochi Health Sciences Center, Ike, 781-8555, Kochi, Kochi, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Watanabe |D Ryouhei |u Matsuyama-shimin Hospital, Ootemachi, 790-0067, Matsuyama, Ehime, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Takahashi |D Ikuo |u Matsuyama Red Cross Hospital, Bunkyo-cho, 790-8524, Matsuyama, Ehime, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Watanabe |D Yuji |u Ehime University School of Medicine, Shitsukawa, 791-0295, Toon, Ehime, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Moriwaki |D Toshikazu |u University of Tsukuba, Tennodai, 305-0006, Tsukuba, Ibaraki, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Maeba |D Takashi |u Social Insurance Ritsurin Hospital, Ritsurin-cho, 760-007, Takamatsu, Kagawa, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hyodo |D Ichinosuke |u University of Tsukuba, Tennodai, 305-0006, Tsukuba, Ibaraki, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t International Journal of Clinical Oncology |d Springer Japan |g 20/1(2015-02-01), 111-116 |x 1341-9625 |q 20:1<111 |1 2015 |2 20 |o 10147 | ||