Performance of p16INK4a/Ki-67 immunocytochemistry for identifying CIN2+ in atypical squamous cells of undetermined significance and low-grade squamous intraepithelial lesion specimens: a Japanese Gynecologic Oncology Group study
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| 024 | 7 | 0 | |a 10.1007/s10147-014-0688-0 |2 doi |
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| 245 | 0 | 0 | |a Performance of p16INK4a/Ki-67 immunocytochemistry for identifying CIN2+ in atypical squamous cells of undetermined significance and low-grade squamous intraepithelial lesion specimens: a Japanese Gynecologic Oncology Group study |h [Elektronische Daten] |c [Takuma Fujii, Miyuki Saito, Toshihiko Hasegawa, Takashi Iwata, Hiroyuki Kuramoto, Kaneyuki Kubushiro, Mineo Ohmura, Kazunori Ochiai, Hiroharu Arai, Masaru Sakamoto, Teiichi Motoyama, Daisuke Aoki] |
| 520 | 3 | |a Background: p16INK4a immunohistochemistry has revealed a high rate of positivity in cervical intraepithelial neoplasia grade 2 (CIN2) and more severe conditions (CIN2+). The Lower Anogenital Squamous Terminology Standardization project proposed p16INK4a immunohistochemistry as an ancillary test for CIN. Immunocytochemistry involving dual staining for p16INK4a and Ki-67 in the triage of atypical squamous cells of undetermined significance (ASCUS) and low-grade squamous intraepithelial lesions (LSIL) is reported to be useful in the identification of CIN2+. However, it is unclear whether p16INK4a/Ki-67 immunocytochemistry is of practical relevance for the triage of ASCUS and LSIL in the Japanese screening system. Methods: From 427 women fulfilling the eligibility criteria, 188 ASCUS and 239 LSIL specimens were analyzed. The accuracy of p16INK4a/Ki-67 immunocytochemistry and genotyping of high-risk human papillomaviruses (HPVs) in detecting CIN2+ were compared. Results: p16INK4a/Ki-67 immunocytochemistry was positive in 33.5% (63/188) of ASCUS, and 36.8% (88/239) of LSIL specimens. The sensitivity and specificity of p16INK4a/Ki-67 immunocytochemistry was 87.3% (95% confidence interval 78.0-93.8%) and 76.4% (71.6-80.8%), respectively. The positive and negative predictive values were 45.7% (37.6-54.0%) and 96.4% (93.4-98.3%), respectively; positive and negative likelihood ratios were 3.71 and 0.17, respectively. Using the McNemar test, p16INK4a/Ki-67 immunocytochemistry showed equivalent sensitivity but higher specificity than the HPV genotyping test Conclusions: Compared with high-risk HPV genotyping, p16INK4a/Ki-67 immunocytochemistry was a more accurate triage test for identifying CIN2+ in ASCUS and LSIL specimens. | |
| 540 | |a Japan Society of Clinical Oncology, 2014 | ||
| 690 | 7 | |a Human papillomavirus |2 nationallicence | |
| 690 | 7 | |a p16 immunocytochemistry |2 nationallicence | |
| 690 | 7 | |a Liquid-based cytology |2 nationallicence | |
| 690 | 7 | |a Cervical cancer screening |2 nationallicence | |
| 690 | 7 | |a Biomarker |2 nationallicence | |
| 700 | 1 | |a Fujii |D Takuma |u Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Saito |D Miyuki |u Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Hasegawa |D Toshihiko |u Department of Gynecology, Tokyo Health Service Association, 1-2, Sadoharacho, Ichigaya, Shinjuku-ku, 162-8402, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Iwata |D Takashi |u Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Kuramoto |D Hiroyuki |u Department of Gynecology, Kanagawa Health Service Association, 58, Nihon Ohdori, Naka-ku, 231-0021, Yokohama, Kanagawa, Japan |4 aut | |
| 700 | 1 | |a Kubushiro |D Kaneyuki |u Department of Obstetrics and Gynecology, Ohashi Medical Center, Toho University School of Medicine, 2-17-6, Ohashi, Megro-ku, 153-8515, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Ohmura |D Mineo |u Department of Gynecology, Kokoro to Karada no Genki Plaza, 3-6-5, Iidabashi, Chiyoda-ku, 102-8508, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Ochiai |D Kazunori |u Department of Obstetrics and Gynecology, The Jikei University School of Medicine, 3-19-18, Nishi-shinbashi, Minato-ku, 105-8471, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Arai |D Hiroharu |u Department of Gynecology, National Tokyo Medical Center, 2-5-1, Higashigaoka, Meguro-ku, 152-8902, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Sakamoto |D Masaru |u Department of Gynecology, Sasaki Foundation Kyoundo Hospital, 1-8, Surugadai, Kanda, Chiyoda-ku, 101-0062, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Motoyama |D Teiichi |u Department of Pathology, Yamagata University School of Medicine, 2-2-2, Iidanishi, 990-9585, Yamagata-city, Yamagata, Japan |4 aut | |
| 700 | 1 | |a Aoki |D Daisuke |u Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan |4 aut | |
| 773 | 0 | |t International Journal of Clinical Oncology |d Springer Japan |g 20/1(2015-02-01), 134-142 |x 1341-9625 |q 20:1<134 |1 2015 |2 20 |o 10147 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10147-014-0688-0 |q text/html |z Onlinezugriff via DOI |
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| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Fujii |D Takuma |u Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Saito |D Miyuki |u Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hasegawa |D Toshihiko |u Department of Gynecology, Tokyo Health Service Association, 1-2, Sadoharacho, Ichigaya, Shinjuku-ku, 162-8402, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Iwata |D Takashi |u Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kuramoto |D Hiroyuki |u Department of Gynecology, Kanagawa Health Service Association, 58, Nihon Ohdori, Naka-ku, 231-0021, Yokohama, Kanagawa, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kubushiro |D Kaneyuki |u Department of Obstetrics and Gynecology, Ohashi Medical Center, Toho University School of Medicine, 2-17-6, Ohashi, Megro-ku, 153-8515, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ohmura |D Mineo |u Department of Gynecology, Kokoro to Karada no Genki Plaza, 3-6-5, Iidabashi, Chiyoda-ku, 102-8508, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ochiai |D Kazunori |u Department of Obstetrics and Gynecology, The Jikei University School of Medicine, 3-19-18, Nishi-shinbashi, Minato-ku, 105-8471, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Arai |D Hiroharu |u Department of Gynecology, National Tokyo Medical Center, 2-5-1, Higashigaoka, Meguro-ku, 152-8902, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sakamoto |D Masaru |u Department of Gynecology, Sasaki Foundation Kyoundo Hospital, 1-8, Surugadai, Kanda, Chiyoda-ku, 101-0062, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Motoyama |D Teiichi |u Department of Pathology, Yamagata University School of Medicine, 2-2-2, Iidanishi, 990-9585, Yamagata-city, Yamagata, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Aoki |D Daisuke |u Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t International Journal of Clinical Oncology |d Springer Japan |g 20/1(2015-02-01), 134-142 |x 1341-9625 |q 20:1<134 |1 2015 |2 20 |o 10147 | ||