caa a22 4500 605490481 CHVBK 20210128100505.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s10147-014-0672-8 doi (NATIONALLICENCE)springer-10.1007/s10147-014-0672-8 Do the derived neutrophil to lymphocyte ratio and the neutrophil to lymphocyte ratio predict prognosis in breast cancer? [Elektronische Daten] [Ahmet Dirican, Betul Kucukzeybek, Ahmet Alacacioglu, Yuksel Kucukzeybek, Cigdem Erten, Umut Varol, Isil Somali, Lutfiye Demir, Ibrahim Bayoglu, Yasar Yildiz, Murat Akyol, Betul Koyuncu, Eyup Coban, Eda Ulger, Fulya Unay, Mustafa Tarhan] Background: The neutrophil-to-lymphocyte ratio (NLR) is a strong predictor of mortality in patients with cancer. Similarly, a study in a large series has shown that the newly defined derived NLR (dNLR; neutrophil/leukocyte-lymphocyte ratio) also has prognostic value. The present study retrospectively evaluates the prognostic significance of NLR and dNLR in breast cancer. Methods: Hematological parameters and clinicopathological data during diagnosis were retrospectively recorded for 1,527 patients diagnosed with breast cancer at Izmir Katip Celebi University Ataturk Research and Training Hospital from January 2006 to December 2011. The cut-off values were determined by calculating the NLR and dNLR of the patients. Results: The cut-off values were determined as 4 and 2 for NLR and dNLR, respectively. The association between NLR and dNLR assessed by Spearman's rank correlation analysis was 0.935 (P<0.001). There was a significant difference regarding disease free survival (DFS) and overall survival (OS) in patients with NLR <4 and NLR ≥4 (respectively, P<0.00, P<0.001). Similarly, there was a significant difference regarding DFS and OS in patients with dNLR <2 and dNLR ≥2 (respectively, P<0.001, P<0.001). Furthermore, NLR and dNLR demonstrated a significant association with the American Joint Committee on Cancer (AJCC) staging (P<0.001). Assessment using the Cox proportional multivariate model showed that high NLR, pN, pT, luminal A-like, luminal B-like (HER2 positive), basal-like, and AJCC staging are independent prognostic factors. Discussion: NLR was shown to be better than dNLR in terms of predicting prognosis in patients with breast cancer. However, large prospective studies are required to further demonstrate the prognostic significance of these two values. Japan Society of Clinical Oncology, 2014 Breast cancer nationallicence Neutrophil nationallicence Lymphocyte nationallicence Prognosis nationallicence Dirican Ahmet Medical Oncology Clinic, Izmir Katip Celebi University Ataturk Training and Research Hospital, 35360, Izmir, Turkey aut Kucukzeybek Betul Department of Pathology, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey aut Alacacioglu Ahmet Medical Oncology Clinic, Izmir Katip Celebi University Ataturk Training and Research Hospital, 35360, Izmir, Turkey aut Kucukzeybek Yuksel Medical Oncology Clinic, Izmir Katip Celebi University Ataturk Training and Research Hospital, 35360, Izmir, Turkey aut Erten Cigdem Medical Oncology Clinic, Izmir Katip Celebi University Ataturk Training and Research Hospital, 35360, Izmir, Turkey aut Varol Umut Medical Oncology Clinic, Izmir Katip Celebi University Ataturk Training and Research Hospital, 35360, Izmir, Turkey aut Somali Isil Medical Oncology Clinic, Izmir Katip Celebi University Ataturk Training and Research Hospital, 35360, Izmir, Turkey aut Demir Lutfiye Medical Oncology Clinic, Izmir Katip Celebi University Ataturk Training and Research Hospital, 35360, Izmir, Turkey aut Bayoglu Ibrahim Medical Oncology Clinic, Izmir Katip Celebi University Ataturk Training and Research Hospital, 35360, Izmir, Turkey aut Yildiz Yasar Medical Oncology Clinic, Izmir Katip Celebi University Ataturk Training and Research Hospital, 35360, Izmir, Turkey aut Akyol Murat Medical Oncology Clinic, Izmir Katip Celebi University Ataturk Training and Research Hospital, 35360, Izmir, Turkey aut Koyuncu Betul Internal Medicine, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey aut Coban Eyup Internal Medicine, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey aut Ulger Eda Department of Social Work, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey aut Unay Fulya Department of Pathology, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey aut Tarhan Mustafa Medical Oncology Clinic, Izmir Katip Celebi University Ataturk Training and Research Hospital, 35360, Izmir, Turkey aut International Journal of Clinical Oncology Springer Japan 20/1(2015-02-01), 70-81 1341-9625 20:1<70 2015 20 10147 https://doi.org/10.1007/s10147-014-0672-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10147-014-0672-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dirican Ahmet Medical Oncology Clinic, Izmir Katip Celebi University Ataturk Training and Research Hospital, 35360, Izmir, Turkey aut NATIONALLICENCE 700 1- Kucukzeybek Betul Department of Pathology, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey aut NATIONALLICENCE 700 1- Alacacioglu Ahmet Medical Oncology Clinic, Izmir Katip Celebi University Ataturk Training and Research Hospital, 35360, Izmir, Turkey aut NATIONALLICENCE 700 1- Kucukzeybek Yuksel Medical Oncology Clinic, Izmir Katip Celebi University Ataturk Training and Research Hospital, 35360, Izmir, Turkey aut NATIONALLICENCE 700 1- Erten Cigdem Medical Oncology Clinic, Izmir Katip Celebi University Ataturk Training and Research Hospital, 35360, Izmir, Turkey aut NATIONALLICENCE 700 1- Varol Umut Medical Oncology Clinic, Izmir Katip Celebi University Ataturk Training and Research Hospital, 35360, Izmir, Turkey aut NATIONALLICENCE 700 1- Somali Isil Medical Oncology Clinic, Izmir Katip Celebi University Ataturk Training and Research Hospital, 35360, Izmir, Turkey aut NATIONALLICENCE 700 1- Demir Lutfiye Medical Oncology Clinic, Izmir Katip Celebi University Ataturk Training and Research Hospital, 35360, Izmir, Turkey aut NATIONALLICENCE 700 1- Bayoglu Ibrahim Medical Oncology Clinic, Izmir Katip Celebi University Ataturk Training and Research Hospital, 35360, Izmir, Turkey aut NATIONALLICENCE 700 1- Yildiz Yasar Medical Oncology Clinic, Izmir Katip Celebi University Ataturk Training and Research Hospital, 35360, Izmir, Turkey aut NATIONALLICENCE 700 1- Akyol Murat Medical Oncology Clinic, Izmir Katip Celebi University Ataturk Training and Research Hospital, 35360, Izmir, Turkey aut NATIONALLICENCE 700 1- Koyuncu Betul Internal Medicine, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey aut NATIONALLICENCE 700 1- Coban Eyup Internal Medicine, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey aut NATIONALLICENCE 700 1- Ulger Eda Department of Social Work, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey aut NATIONALLICENCE 700 1- Unay Fulya Department of Pathology, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey aut NATIONALLICENCE 700 1- Tarhan Mustafa Medical Oncology Clinic, Izmir Katip Celebi University Ataturk Training and Research Hospital, 35360, Izmir, Turkey aut NATIONALLICENCE 773 0- International Journal of Clinical Oncology Springer Japan 20/1(2015-02-01), 70-81 1341-9625 20:1<70 2015 20 10147