Development of hypertension within 2 weeks of initiation of sorafenib for advanced hepatocellular carcinoma is a predictor of efficacy
| LEADER | caa a22 4500 | ||
|---|---|---|---|
| 001 | 60549049X | ||
| 003 | CHVBK | ||
| 005 | 20210128100505.0 | ||
| 007 | cr unu---uuuuu | ||
| 008 | 210128e20150201xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1007/s10147-014-0691-5 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10147-014-0691-5 | ||
| 245 | 0 | 0 | |a Development of hypertension within 2 weeks of initiation of sorafenib for advanced hepatocellular carcinoma is a predictor of efficacy |h [Elektronische Daten] |c [Noriyuki Akutsu, Shigeru Sasaki, Hideyasu Takagi, Masayo Motoya, Masahiro Shitani, Mai Igarashi, Daisuke Hirayama, Hideki Wakasugi, Hiroyuki Yamamoto, Hiroyuki Kaneto, Kazuhiko Yonezawa, Atsushi Yawata, Takeya Adachi, Yasuo Hamamoto, Yasuhisa Shinomura] |
| 520 | 3 | |a Background: Sorafenib is an agent that inhibits vascular endothelial growth factor and is associated with onset or worsening of hypertension in some patients. We conducted a retrospective analysis of whether the development of hypertension during sorafenib treatment of advanced hepatocellular carcinoma could be a predictor of anti-cancer efficacy. Methods: The study included 38 patients with advanced hepatocellular carcinoma who had received sorafenib for at least 1month between January 2010 and December 2012. A retrospective analysis of the efficacy of sorafenib was conducted by dividing the patients into two groups—a hypertension group, presenting with grade 2 or higher hypertension according to the Common Terminology Criteria for Adverse Events (CTCTE) version 4.0; and a non-hypertension group, which included all other patients. This study evaluated the occurrence of hypertension within 2 weeks of initiation of therapy in order to avoid any treatment duration bias. Images were evaluated using the modified Response Evaluation Criteria in Solid Tumors. The response rate, time to progression, and overall survival were assessed. Results: Twenty-two patients (58%) developed grade 2 or higher hypertension within 2 weeks of initiation of therapy. The response rate was significantly higher in the hypertension group. Median time to progression was 153days in the hypertension group versus 50.5days in the non-hypertension group, which was significantly longer in the hypertension group. Moreover, median overall survival was 1,329days in the hypertension group versus 302days in the non-hypertension group, which was significantly longer in the hypertension group. Conclusions: Hypertension within 2 weeks of initiation of therapy may be a predictor of the anti-cancer efficacy of sorafenib when used for the treatment of advanced hepatocellular carcinoma. | |
| 540 | |a Japan Society of Clinical Oncology, 2014 | ||
| 690 | 7 | |a Hepatocellular carcinoma |2 nationallicence | |
| 690 | 7 | |a Hypertension |2 nationallicence | |
| 690 | 7 | |a Sorafenib |2 nationallicence | |
| 700 | 1 | |a Akutsu |D Noriyuki |u Department of Gastroenterology, Rheumatology, and Clinical Immunology, Sapporo Medical University, S-1, W-16, Chuo-ku, 060-8543, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Sasaki |D Shigeru |u Department of Gastroenterology, Rheumatology, and Clinical Immunology, Sapporo Medical University, S-1, W-16, Chuo-ku, 060-8543, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Takagi |D Hideyasu |u Department of Gastroenterology, Rheumatology, and Clinical Immunology, Sapporo Medical University, S-1, W-16, Chuo-ku, 060-8543, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Motoya |D Masayo |u Department of Gastroenterology, Rheumatology, and Clinical Immunology, Sapporo Medical University, S-1, W-16, Chuo-ku, 060-8543, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Shitani |D Masahiro |u Department of Gastroenterology, Rheumatology, and Clinical Immunology, Sapporo Medical University, S-1, W-16, Chuo-ku, 060-8543, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Igarashi |D Mai |u Department of Gastroenterology, Rheumatology, and Clinical Immunology, Sapporo Medical University, S-1, W-16, Chuo-ku, 060-8543, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Hirayama |D Daisuke |u Department of Gastroenterology, Rheumatology, and Clinical Immunology, Sapporo Medical University, S-1, W-16, Chuo-ku, 060-8543, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Wakasugi |D Hideki |u Department of Gastroenterology, Rheumatology, and Clinical Immunology, Sapporo Medical University, S-1, W-16, Chuo-ku, 060-8543, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Yamamoto |D Hiroyuki |u Department of Gastroenterology, Rheumatology, and Clinical Immunology, Sapporo Medical University, S-1, W-16, Chuo-ku, 060-8543, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Kaneto |D Hiroyuki |u Department of Gastroenterology, Muroran City General Hospital, 3-8-1 Yamatecho, 051-8512, Muroran, Hokkaido, Japan |4 aut | |
| 700 | 1 | |a Yonezawa |D Kazuhiko |u Department of Gastroenterology, Kushiro City General Hospital, 1-12 Shunkodai, 085-0822, Kushiro, Hokkaido, Japan |4 aut | |
| 700 | 1 | |a Yawata |D Atsushi |u Department of Gastroenterology, Hakodate Goryoukaku Hospital, 38-3 Goryoukaku, 040-8611, Hakodate, Hokkaido, Japan |4 aut | |
| 700 | 1 | |a Adachi |D Takeya |u Department of Gastroenterology, Otaru City General Hospital, 1-2-1 Wakamatsu, 047-8550, Otaru, Hokkaido, Japan |4 aut | |
| 700 | 1 | |a Hamamoto |D Yasuo |u Division of Gastroenterology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Shinomura |D Yasuhisa |u Department of Gastroenterology, Rheumatology, and Clinical Immunology, Sapporo Medical University, S-1, W-16, Chuo-ku, 060-8543, Sapporo, Japan |4 aut | |
| 773 | 0 | |t International Journal of Clinical Oncology |d Springer Japan |g 20/1(2015-02-01), 105-110 |x 1341-9625 |q 20:1<105 |1 2015 |2 20 |o 10147 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10147-014-0691-5 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10147-014-0691-5 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Akutsu |D Noriyuki |u Department of Gastroenterology, Rheumatology, and Clinical Immunology, Sapporo Medical University, S-1, W-16, Chuo-ku, 060-8543, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sasaki |D Shigeru |u Department of Gastroenterology, Rheumatology, and Clinical Immunology, Sapporo Medical University, S-1, W-16, Chuo-ku, 060-8543, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Takagi |D Hideyasu |u Department of Gastroenterology, Rheumatology, and Clinical Immunology, Sapporo Medical University, S-1, W-16, Chuo-ku, 060-8543, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Motoya |D Masayo |u Department of Gastroenterology, Rheumatology, and Clinical Immunology, Sapporo Medical University, S-1, W-16, Chuo-ku, 060-8543, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Shitani |D Masahiro |u Department of Gastroenterology, Rheumatology, and Clinical Immunology, Sapporo Medical University, S-1, W-16, Chuo-ku, 060-8543, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Igarashi |D Mai |u Department of Gastroenterology, Rheumatology, and Clinical Immunology, Sapporo Medical University, S-1, W-16, Chuo-ku, 060-8543, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hirayama |D Daisuke |u Department of Gastroenterology, Rheumatology, and Clinical Immunology, Sapporo Medical University, S-1, W-16, Chuo-ku, 060-8543, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Wakasugi |D Hideki |u Department of Gastroenterology, Rheumatology, and Clinical Immunology, Sapporo Medical University, S-1, W-16, Chuo-ku, 060-8543, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yamamoto |D Hiroyuki |u Department of Gastroenterology, Rheumatology, and Clinical Immunology, Sapporo Medical University, S-1, W-16, Chuo-ku, 060-8543, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kaneto |D Hiroyuki |u Department of Gastroenterology, Muroran City General Hospital, 3-8-1 Yamatecho, 051-8512, Muroran, Hokkaido, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yonezawa |D Kazuhiko |u Department of Gastroenterology, Kushiro City General Hospital, 1-12 Shunkodai, 085-0822, Kushiro, Hokkaido, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yawata |D Atsushi |u Department of Gastroenterology, Hakodate Goryoukaku Hospital, 38-3 Goryoukaku, 040-8611, Hakodate, Hokkaido, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Adachi |D Takeya |u Department of Gastroenterology, Otaru City General Hospital, 1-2-1 Wakamatsu, 047-8550, Otaru, Hokkaido, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hamamoto |D Yasuo |u Division of Gastroenterology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Shinomura |D Yasuhisa |u Department of Gastroenterology, Rheumatology, and Clinical Immunology, Sapporo Medical University, S-1, W-16, Chuo-ku, 060-8543, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t International Journal of Clinical Oncology |d Springer Japan |g 20/1(2015-02-01), 105-110 |x 1341-9625 |q 20:1<105 |1 2015 |2 20 |o 10147 | ||