caa a22 4500 605490503 CHVBK 20210128100505.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s10147-015-0840-5 doi (NATIONALLICENCE)springer-10.1007/s10147-015-0840-5 Outcomes of curative nephrectomy against renal cell carcinoma based on a central pathological review of 914 specimens from the era of cytokine treatment [Elektronische Daten] [Noriyuki Ito, Shinsuke Kojima, Satoshi Teramukai, Yoshiki Mikami, Osamu Ogawa, Tomomi Kamba] Background: The purpose of this study was to determine the state of modern practice with regard to renal cell carcinoma (RCC) outcomes and to assess the effects on survival of such clinical and pathological factors such as histological subtype (HS) and nuclear grade by conducting a central pathological review based on the current World Health Organization classification and the staging system of the American Joint Committee on Cancer/Union for International Cancer Control. Methods: We collected glass slides and clinical data sets for 914 cases of RCC treated with curative nephrectomy from 1995 to 2000. Overall (OS), cancer-specific (CSS), and relapse-free (RFS) survival were compared for HS and nuclear grades determined by a central pathology review board comprising 5 board-certified pathologists, pathological staging, and a variety of clinical factors. Results: The 5 and 7-year CSS in this study were 96 and 93%, respectively, values superior to those reported in Western countries. Concordance between the original and reviewed HS and nuclear grades were 90.9 and 21.1%, respectively. HS correlated with OS (P=0.043) but was not an independent prognostic factor in the multivariate analysis (P=0.820). Tumor size, Fuhrman grade, and infiltration type were common independent prognostic factors for OS, CSS, and RFS. Conclusions: This study revealed RCC outcomes in the era of cytokine treatment for metastasis. Central pathological review is an essential component of a multicenter study with long-term follow-up. Tumor size, Fuhrman grade, and infiltration type had much greater effects than HS on survival after curative nephrectomy. Japan Society of Clinical Oncology, 2015 Central pathology nationallicence Cytokine nationallicence Histological subtypes nationallicence Prognostic factors nationallicence Renal cell carcinoma nationallicence Ito Noriyuki Department of Urology, Nishi-Kobe Medical Center, 651-2273, Kobe, Japan aut Kojima Shinsuke Translational Research Informatics Center, Foundation for Biomedical Research and Innovation, Kobe, Japan aut Teramukai Satoshi Department of Biostatistics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan aut Mikami Yoshiki Department of Diagnostic Pathology, Kumamoto University Hospital, Kumamoto, Japan aut Ogawa Osamu Department of Urology, Graduate School of Medicine, Kyoto University, Kyoto, Japan aut Kamba Tomomi Department of Urology, Graduate School of Medicine, Kyoto University, Kyoto, Japan aut International Journal of Clinical Oncology Springer Japan 20/6(2015-12-01), 1161-1170 1341-9625 20:6<1161 2015 20 10147 https://doi.org/10.1007/s10147-015-0840-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10147-015-0840-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ito Noriyuki Department of Urology, Nishi-Kobe Medical Center, 651-2273, Kobe, Japan aut NATIONALLICENCE 700 1- Kojima Shinsuke Translational Research Informatics Center, Foundation for Biomedical Research and Innovation, Kobe, Japan aut NATIONALLICENCE 700 1- Teramukai Satoshi Department of Biostatistics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan aut NATIONALLICENCE 700 1- Mikami Yoshiki Department of Diagnostic Pathology, Kumamoto University Hospital, Kumamoto, Japan aut NATIONALLICENCE 700 1- Ogawa Osamu Department of Urology, Graduate School of Medicine, Kyoto University, Kyoto, Japan aut NATIONALLICENCE 700 1- Kamba Tomomi Department of Urology, Graduate School of Medicine, Kyoto University, Kyoto, Japan aut NATIONALLICENCE 773 0- International Journal of Clinical Oncology Springer Japan 20/6(2015-12-01), 1161-1170 1341-9625 20:6<1161 2015 20 10147