caa a22 4500 605490546 CHVBK 20210128100505.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s10147-015-0835-2 doi (NATIONALLICENCE)springer-10.1007/s10147-015-0835-2 Predictors of long-term survival in patients with stage IV colorectal cancer with multi-organ metastases: a single-center retrospective analysis [Elektronische Daten] [Yuji Miyamoto, Naoko Hayashi, Yasuo Sakamoto, Mayuko Ohuchi, Ryuma Tokunagam, Junji Kurashige, Yukiharu Hiyoshi, Yoshifumi Baba, Shiro Iwagami, Naoya Yoshida, Megumi Yoshida, Hideo Baba] Background: The prognosis for most patients with stage IV colorectal cancer (CRC) and multi-organ metastases is poor. However, little information is currently available on prognostic factors in these patients. The aim of this study was to identify predictors of a good prognosis in this patient group. Methods: This was a single-center retrospective study in which we examined the relationship between patient characteristics and prognosis in 161 stage IV CRC patients with indications for first-line systemic chemotherapy. Cox proportional-hazards models were used to compute hazard ratios (HR) for death, adjusted for clinical and pathological characteristics. Results: Of the 161 patients recruited to the study, 83 had single-organ and 78 had multi-organ metastases. Median survival time was significantly shorter in patients with multi-organ metastases than in those with single-organ metastases (19.2 vs. 42.0months, respectively; log-rank, P<0.001). There was no significant difference in survival between patients with metastases in two versus three or more organs (log-rank; P=0.368). According to univariate analysis, primary tumor sites in the left side of the colon and in the rectum, a pretreatment carcinoembryonic antigen concentration of >50ng/mL, a well-/moderately differentiated tumor, and R0 resection of metastatic lesions were associated with better overall survival. According to multivariate analysis, left-sided location of the primary tumor [HR 0.414, 95% confidence interval (CI) 0.216-0.815; P=0.011] and R0 resection of metastatic lesions (HR 0.247, 95% CI 0.04 0-0.834; P=0.021) were independently associated with good prognosis. Conclusions: Our results indicate that the site of the primary tumor in the left side of the colon and in the rectum and R0 resection of metastatic lesions are predictors of a good prognosis in patients with stage IV CRC and multi-organ metastases. Japan Society of Clinical Oncology, 2015 Colorectal cancer nationallicence Stage IV nationallicence Multi-organ metastasis nationallicence Prognostic factor nationallicence Miyamoto Yuji Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut Hayashi Naoko Department of Surgery, National Hospital Organization Kumamoto Hospital, 2338 Matsubase, 869-0593, Uki, Japan aut Sakamoto Yasuo Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut Ohuchi Mayuko Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut Tokunagam Ryuma Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut Kurashige Junji Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut Hiyoshi Yukiharu Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut Baba Yoshifumi Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut Iwagami Shiro Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut Yoshida Naoya Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut Yoshida Megumi Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut Baba Hideo Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut International Journal of Clinical Oncology Springer Japan 20/6(2015-12-01), 1140-1146 1341-9625 20:6<1140 2015 20 10147 https://doi.org/10.1007/s10147-015-0835-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10147-015-0835-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Miyamoto Yuji Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut NATIONALLICENCE 700 1- Hayashi Naoko Department of Surgery, National Hospital Organization Kumamoto Hospital, 2338 Matsubase, 869-0593, Uki, Japan aut NATIONALLICENCE 700 1- Sakamoto Yasuo Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut NATIONALLICENCE 700 1- Ohuchi Mayuko Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut NATIONALLICENCE 700 1- Tokunagam Ryuma Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut NATIONALLICENCE 700 1- Kurashige Junji Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut NATIONALLICENCE 700 1- Hiyoshi Yukiharu Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut NATIONALLICENCE 700 1- Baba Yoshifumi Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut NATIONALLICENCE 700 1- Iwagami Shiro Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut NATIONALLICENCE 700 1- Yoshida Naoya Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut NATIONALLICENCE 700 1- Yoshida Megumi Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut NATIONALLICENCE 700 1- Baba Hideo Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan aut NATIONALLICENCE 773 0- International Journal of Clinical Oncology Springer Japan 20/6(2015-12-01), 1140-1146 1341-9625 20:6<1140 2015 20 10147