Predictive markers of chemoradiotherapy for rectal cancer: comparison of biopsy specimens taken before and about 1week after the start of chemoradiotherapy
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| 024 | 7 | 0 | |a 10.1007/s10147-015-0822-7 |2 doi |
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| 245 | 0 | 0 | |a Predictive markers of chemoradiotherapy for rectal cancer: comparison of biopsy specimens taken before and about 1week after the start of chemoradiotherapy |h [Elektronische Daten] |c [Toshiyuki Suzuki, Sotaro Sadahiro, Akira Tanaka, Kazutake Okada, Gota Saito, Akemi Kamijo, Takeshi Akiba, Shuichi Kawada] |
| 520 | 3 | |a Background: Preoperative chemoradiotherapy (CRT) significantly decreases local recurrence in patients with rectal cancer. Although various biomarkers in biopsy specimens obtained before starting CRT have been examined, reliable prognostic factors have yet to be established. We tested the hypothesis that biopsy specimens obtained soon after the start of CRT can be used as prognostic factors. Methods: Preoperative CRT was given to 70 consecutive patients with rectal cancer. Biopsies were taken before and about 7days after starting CRT. The specimens were stained with hematoxylin and eosin (HE), and the expressions of Ki67, p53, and p21 and apoptosis were evaluated immunohistochemically. Results: The expressions of Ki67, p53, and p21 and apoptosis before treatment were not significantly related to histologic response or tumor shrinkage. In specimens obtained about 7days after CRT began, marked histologic regression was significantly higher in p21-positive, apoptosis-positive cases, and in cases with moderate changes on HE specimens (p=0.017, p=0.010, and p=0.004, respectively). The tumor shrinkage was significantly higher in apoptosis-positive cases and cases with moderate changes on HE specimens (p=0.002 and p<0.001, respectively). Disease-free survival (DFS) was significantly higher in patients who had marked regression than in those who did not (p=0.019). DFS was also significantly higher in patients with moderate changes on HE specimens than in those with mild changes (p=0.016). Conclusions: Changes on HE-stained biopsy specimens obtained about 1week after starting CRT are a reliable prognostic factor, similar to histologic marked regression in resected specimens; a major advantage is that the former results are available at an early phase. | |
| 540 | |a Japan Society of Clinical Oncology, 2015 | ||
| 690 | 7 | |a Rectal cancer |2 nationallicence | |
| 690 | 7 | |a Chemoradiotherapy |2 nationallicence | |
| 690 | 7 | |a Prognostic factor |2 nationallicence | |
| 700 | 1 | |a Suzuki |D Toshiyuki |u Department of Surgery, Tokai University, 143 Shimokasuya, 259-1193, Isehara, Kanagawa, Japan |4 aut | |
| 700 | 1 | |a Sadahiro |D Sotaro |u Department of Surgery, Tokai University, 143 Shimokasuya, 259-1193, Isehara, Kanagawa, Japan |4 aut | |
| 700 | 1 | |a Tanaka |D Akira |u Department of Surgery, Tokai University, 143 Shimokasuya, 259-1193, Isehara, Kanagawa, Japan |4 aut | |
| 700 | 1 | |a Okada |D Kazutake |u Department of Surgery, Tokai University, 143 Shimokasuya, 259-1193, Isehara, Kanagawa, Japan |4 aut | |
| 700 | 1 | |a Saito |D Gota |u Department of Surgery, Tokai University, 143 Shimokasuya, 259-1193, Isehara, Kanagawa, Japan |4 aut | |
| 700 | 1 | |a Kamijo |D Akemi |u Department of Surgery, Tokai University, 143 Shimokasuya, 259-1193, Isehara, Kanagawa, Japan |4 aut | |
| 700 | 1 | |a Akiba |D Takeshi |u Department of Radiology, Tokai University, Isehara, Kanagawa, Japan |4 aut | |
| 700 | 1 | |a Kawada |D Shuichi |u Department of Radiology, Tokai University, Isehara, Kanagawa, Japan |4 aut | |
| 773 | 0 | |t International Journal of Clinical Oncology |d Springer Japan |g 20/6(2015-12-01), 1130-1139 |x 1341-9625 |q 20:6<1130 |1 2015 |2 20 |o 10147 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10147-015-0822-7 |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10147-015-0822-7 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Suzuki |D Toshiyuki |u Department of Surgery, Tokai University, 143 Shimokasuya, 259-1193, Isehara, Kanagawa, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sadahiro |D Sotaro |u Department of Surgery, Tokai University, 143 Shimokasuya, 259-1193, Isehara, Kanagawa, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tanaka |D Akira |u Department of Surgery, Tokai University, 143 Shimokasuya, 259-1193, Isehara, Kanagawa, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Okada |D Kazutake |u Department of Surgery, Tokai University, 143 Shimokasuya, 259-1193, Isehara, Kanagawa, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Saito |D Gota |u Department of Surgery, Tokai University, 143 Shimokasuya, 259-1193, Isehara, Kanagawa, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kamijo |D Akemi |u Department of Surgery, Tokai University, 143 Shimokasuya, 259-1193, Isehara, Kanagawa, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Akiba |D Takeshi |u Department of Radiology, Tokai University, Isehara, Kanagawa, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kawada |D Shuichi |u Department of Radiology, Tokai University, Isehara, Kanagawa, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t International Journal of Clinical Oncology |d Springer Japan |g 20/6(2015-12-01), 1130-1139 |x 1341-9625 |q 20:6<1130 |1 2015 |2 20 |o 10147 | ||