Clinical significance of hypoxia-inducible factor 1 and VEGF-A in osteosarcoma
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| 001 | 605490589 | ||
| 003 | CHVBK | ||
| 005 | 20210128100505.0 | ||
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| 008 | 210128e20151201xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1007/s10147-015-0848-x |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10147-015-0848-x | ||
| 245 | 0 | 0 | |a Clinical significance of hypoxia-inducible factor 1 and VEGF-A in osteosarcoma |h [Elektronische Daten] |c [Huanli Zhao, Yuhui Wu, Yang Chen, Hongmei Liu] |
| 520 | 3 | |a Background: Although the function of hypoxia-inducible factor 1 (HIF1) in many kinds of solid tumor has been revealed, the significance of HIF1 in osteosarcoma is still controversial and not well understood. Methods: Immunohistochemistry was used to detect HIF1 expression. The correlation between HIF1 and clinicopathology factors was analyzed by use of chi-squared tests. The prognostic value of HIF1 was evaluated by univariate and multivariate analysis. Moreover, the function of HIF1 in osteosarcoma cells was further investigated in in-vitro experiments by regulating HIF1 and vascular endothelial growth factor-A (VEGF-A) expression. Results: Expression of HIF1 was high for 56.82% of the samples in our investigation. HIF1 expression was significantly associated with positive metastasis (P=0.037). By use of the Kaplan-Meier method, high expression of HIF1 was proved to be related to poorer overall survival (P=0.007). By use of a Cox-regression model, HIF1 was identified as an independent prognostic biomarker (P=0.019). We also proved that HIF1 can promote osteosarcoma invasion in hypoxia by inducing VEGF-A expression. Conclusions: HIF1 was identified as an independent prognostic biomarker in osteosarcoma. It can promote osteosarcoma cell invasion by inducing VEGF-A expression, indicating that HIF1 is a potential drug target in osteosarcoma. | |
| 540 | |a Japan Society of Clinical Oncology, 2015 | ||
| 690 | 7 | |a Hypoxia-inducible factor 1 |2 nationallicence | |
| 690 | 7 | |a Osteosarcoma |2 nationallicence | |
| 690 | 7 | |a VEGF-A |2 nationallicence | |
| 690 | 7 | |a Prognosis |2 nationallicence | |
| 690 | 7 | |a Invasion |2 nationallicence | |
| 700 | 1 | |a Zhao |D Huanli |u Department of Orthopedics, Linyi People's Hospital, 276003, Linyi, China |4 aut | |
| 700 | 1 | |a Wu |D Yuhui |u Department of Orthopedics, Linyi People's Hospital, 276003, Linyi, China |4 aut | |
| 700 | 1 | |a Chen |D Yang |u Department of Orthopedics, Linyi People's Hospital, 276003, Linyi, China |4 aut | |
| 700 | 1 | |a Liu |D Hongmei |u Department of Surgery, Linyi People's Hospital, 276003, Linyi, Shangdong Province, China |4 aut | |
| 773 | 0 | |t International Journal of Clinical Oncology |d Springer Japan |g 20/6(2015-12-01), 1233-1243 |x 1341-9625 |q 20:6<1233 |1 2015 |2 20 |o 10147 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10147-015-0848-x |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10147-015-0848-x |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zhao |D Huanli |u Department of Orthopedics, Linyi People's Hospital, 276003, Linyi, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Wu |D Yuhui |u Department of Orthopedics, Linyi People's Hospital, 276003, Linyi, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Chen |D Yang |u Department of Orthopedics, Linyi People's Hospital, 276003, Linyi, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Liu |D Hongmei |u Department of Surgery, Linyi People's Hospital, 276003, Linyi, Shangdong Province, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t International Journal of Clinical Oncology |d Springer Japan |g 20/6(2015-12-01), 1233-1243 |x 1341-9625 |q 20:6<1233 |1 2015 |2 20 |o 10147 | ||