Clinical outcomes of weekly cisplatin chemoradiotherapy for patients with pyriform sinus cancer
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| 024 | 7 | 0 | |a 10.1007/s10147-015-0821-8 |2 doi |
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| 245 | 0 | 0 | |a Clinical outcomes of weekly cisplatin chemoradiotherapy for patients with pyriform sinus cancer |h [Elektronische Daten] |c [Tomohiro Sakashita, Akihiro Homma, Hiromitsu Hatakeyama, Jun Furusawa, Satoshi Kano, Takatsugu Mizumachi, Satoshi Iizuka, Rikiya Onimaru, Kazuhiko Tsuchiya, Koichi Yasuda, Hiroki Shirato, Satoshi Fukuda] |
| 520 | 3 | |a Background: Pyriform sinus squamous cell carcinoma (SCC) has one of the worst prognoses of all upper aerodigestive tract cancers. Improving clinical outcomes for patients with hypopharyngeal SCC has been particularly challenging for head and neck surgeons and oncologists. Methods: We investigated 30 patients with pyriform sinus SCC to verify the effectiveness of weekly cisplatin chemotherapy with concurrent radiotherapy. Cisplatin was administered at a dose of 40mg/m2 on weeks 1, 2, 3, 5, 6, and 7 during definitive radiotherapy with the aim of preserving the larynx. Results: All 30 patients achieved definitive radiotherapy at a median dose of 70Gy (range 64-70Gy). Cisplatin was administrated concomitantly a median of five times (range 2-6 times). Persistent or recurrent primary disease was observed in four patients (13%). Persistent or recurrent nodal metastasis was observed in five patients (17%). Nine salvage surgeries were performed for eight patients, of whom seven survived without any evidence of disease. Post-operative complications were observed in two patients (22%). The 5-year overall survival and locoregional control rates were 87 and 96%, respectively. The 5-year laryngeal preservation rate was 74%. Conclusions: The regimen of weekly cisplatin CRT may be effective for pyriform sinus SCC; however, there were problems with strong selection bias in the current study due to the large number of T2 patients. Salvage surgery was safe and was able to improve the survival rate. This chemoradiation regimen was considered successful in preserving laryngeal function. | |
| 540 | |a Japan Society of Clinical Oncology, 2015 | ||
| 690 | 7 | |a Chemoradiation |2 nationallicence | |
| 690 | 7 | |a Hypopharyngeal cancer |2 nationallicence | |
| 690 | 7 | |a Laryngeal preservation |2 nationallicence | |
| 700 | 1 | |a Sakashita |D Tomohiro |u Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Homma |D Akihiro |u Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Hatakeyama |D Hiromitsu |u Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Furusawa |D Jun |u Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Kano |D Satoshi |u Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Mizumachi |D Takatsugu |u Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Iizuka |D Satoshi |u Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Onimaru |D Rikiya |u Department of Radiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Tsuchiya |D Kazuhiko |u Department of Radiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Yasuda |D Koichi |u Department of Radiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Shirato |D Hiroki |u Department of Radiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Fukuda |D Satoshi |u Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan |4 aut | |
| 773 | 0 | |t International Journal of Clinical Oncology |d Springer Japan |g 20/6(2015-12-01), 1081-1085 |x 1341-9625 |q 20:6<1081 |1 2015 |2 20 |o 10147 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10147-015-0821-8 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10147-015-0821-8 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sakashita |D Tomohiro |u Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Homma |D Akihiro |u Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hatakeyama |D Hiromitsu |u Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Furusawa |D Jun |u Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kano |D Satoshi |u Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Mizumachi |D Takatsugu |u Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Iizuka |D Satoshi |u Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Onimaru |D Rikiya |u Department of Radiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tsuchiya |D Kazuhiko |u Department of Radiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yasuda |D Koichi |u Department of Radiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Shirato |D Hiroki |u Department of Radiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Fukuda |D Satoshi |u Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t International Journal of Clinical Oncology |d Springer Japan |g 20/6(2015-12-01), 1081-1085 |x 1341-9625 |q 20:6<1081 |1 2015 |2 20 |o 10147 | ||