caa a22 4500 605490600 CHVBK 20210128100505.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s10147-015-0821-8 doi (NATIONALLICENCE)springer-10.1007/s10147-015-0821-8 Clinical outcomes of weekly cisplatin chemoradiotherapy for patients with pyriform sinus cancer [Elektronische Daten] [Tomohiro Sakashita, Akihiro Homma, Hiromitsu Hatakeyama, Jun Furusawa, Satoshi Kano, Takatsugu Mizumachi, Satoshi Iizuka, Rikiya Onimaru, Kazuhiko Tsuchiya, Koichi Yasuda, Hiroki Shirato, Satoshi Fukuda] Background: Pyriform sinus squamous cell carcinoma (SCC) has one of the worst prognoses of all upper aerodigestive tract cancers. Improving clinical outcomes for patients with hypopharyngeal SCC has been particularly challenging for head and neck surgeons and oncologists. Methods: We investigated 30 patients with pyriform sinus SCC to verify the effectiveness of weekly cisplatin chemotherapy with concurrent radiotherapy. Cisplatin was administered at a dose of 40mg/m2 on weeks 1, 2, 3, 5, 6, and 7 during definitive radiotherapy with the aim of preserving the larynx. Results: All 30 patients achieved definitive radiotherapy at a median dose of 70Gy (range 64-70Gy). Cisplatin was administrated concomitantly a median of five times (range 2-6 times). Persistent or recurrent primary disease was observed in four patients (13%). Persistent or recurrent nodal metastasis was observed in five patients (17%). Nine salvage surgeries were performed for eight patients, of whom seven survived without any evidence of disease. Post-operative complications were observed in two patients (22%). The 5-year overall survival and locoregional control rates were 87 and 96%, respectively. The 5-year laryngeal preservation rate was 74%. Conclusions: The regimen of weekly cisplatin CRT may be effective for pyriform sinus SCC; however, there were problems with strong selection bias in the current study due to the large number of T2 patients. Salvage surgery was safe and was able to improve the survival rate. This chemoradiation regimen was considered successful in preserving laryngeal function. Japan Society of Clinical Oncology, 2015 Chemoradiation nationallicence Hypopharyngeal cancer nationallicence Laryngeal preservation nationallicence Sakashita Tomohiro Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan aut Homma Akihiro Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan aut Hatakeyama Hiromitsu Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan aut Furusawa Jun Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan aut Kano Satoshi Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan aut Mizumachi Takatsugu Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan aut Iizuka Satoshi Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan aut Onimaru Rikiya Department of Radiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan aut Tsuchiya Kazuhiko Department of Radiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan aut Yasuda Koichi Department of Radiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan aut Shirato Hiroki Department of Radiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan aut Fukuda Satoshi Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan aut International Journal of Clinical Oncology Springer Japan 20/6(2015-12-01), 1081-1085 1341-9625 20:6<1081 2015 20 10147 https://doi.org/10.1007/s10147-015-0821-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10147-015-0821-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sakashita Tomohiro Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan aut NATIONALLICENCE 700 1- Homma Akihiro Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan aut NATIONALLICENCE 700 1- Hatakeyama Hiromitsu Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan aut NATIONALLICENCE 700 1- Furusawa Jun Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan aut NATIONALLICENCE 700 1- Kano Satoshi Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan aut NATIONALLICENCE 700 1- Mizumachi Takatsugu Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan aut NATIONALLICENCE 700 1- Iizuka Satoshi Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan aut NATIONALLICENCE 700 1- Onimaru Rikiya Department of Radiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan aut NATIONALLICENCE 700 1- Tsuchiya Kazuhiko Department of Radiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan aut NATIONALLICENCE 700 1- Yasuda Koichi Department of Radiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan aut NATIONALLICENCE 700 1- Shirato Hiroki Department of Radiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan aut NATIONALLICENCE 700 1- Fukuda Satoshi Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan aut NATIONALLICENCE 773 0- International Journal of Clinical Oncology Springer Japan 20/6(2015-12-01), 1081-1085 1341-9625 20:6<1081 2015 20 10147