Amyloidosis and the risk of cancer: a nationwide population-based study

Verfasser / Beitragende:
[Vincent Su, Chia-Jen Liu, Yu-Wen Hu, Wei-Juin Su, Yuh-Min Chen, Shinn-Liang Lai, Tzeng-Ji Chen, Diahn-Warng Perng, Yu-Chin Lee, Cheng-Hwai Tzeng, Kun-Ta Chou]
Ort, Verlag, Jahr:
2015
Enthalten in:
International Journal of Clinical Oncology, 20/6(2015-12-01), 1244-1251
Format:
Artikel (online)
ID: 605490627
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024 7 0 |a 10.1007/s10147-015-0849-9  |2 doi 
035 |a (NATIONALLICENCE)springer-10.1007/s10147-015-0849-9 
245 0 0 |a Amyloidosis and the risk of cancer: a nationwide population-based study  |h [Elektronische Daten]  |c [Vincent Su, Chia-Jen Liu, Yu-Wen Hu, Wei-Juin Su, Yuh-Min Chen, Shinn-Liang Lai, Tzeng-Ji Chen, Diahn-Warng Perng, Yu-Chin Lee, Cheng-Hwai Tzeng, Kun-Ta Chou] 
520 3 |a Background: The association between amyloidosis and cancer remains unclear. Participants and methods: Using the Taiwan National Health Insurance Research Database we conducted a population-based cohort study. Patients newly diagnosed with amyloidosis between 1997 and 2009 were enrolled. Patients with antecedent cancer were excluded. Standardized incidence ratios (SIR) of cancers were calculated for the study cohort and compared with cancer incidence among the general population. We used a multivariate Cox regression model to evaluate the predictors of cancer development for patients with amyloidosis. Results: The study included 1,693 subjects with median follow-up of 5.63years. A total of 68 patients developed cancer. The incidence of kidney cancer (SIR 3.42; 95% CI 1.11-7.97; p=0.034) and hematologic malignancies (SIR 3.88; 95% CI 1.86-7.14; p<0.001) were significantly higher for patients with amyloidosis. Conclusion: This is currently the largest study to evaluate cancer risk among patients with amyloidosis. The results indicate that amyloidosis may be associated with an increased risk of kidney cancer and hematologic malignancies. 
540 |a Japan Society of Clinical Oncology, 2015 
690 7 |a Amyloidosis  |2 nationallicence 
690 7 |a Cancer  |2 nationallicence 
690 7 |a Kidney cancer  |2 nationallicence 
690 7 |a Hematologic malignancies  |2 nationallicence 
700 1 |a Su  |D Vincent  |u Department of Chest Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, 112, Taipei, Taiwan  |4 aut 
700 1 |a Liu  |D Chia-Jen  |u Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan  |4 aut 
700 1 |a Hu  |D Yu-Wen  |u Cancer Center, Taipei Veterans General Hospital, Taipei, Taiwan  |4 aut 
700 1 |a Su  |D Wei-Juin  |u Department of Chest Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, 112, Taipei, Taiwan  |4 aut 
700 1 |a Chen  |D Yuh-Min  |u Department of Chest Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, 112, Taipei, Taiwan  |4 aut 
700 1 |a Lai  |D Shinn-Liang  |u Department of Chest Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, 112, Taipei, Taiwan  |4 aut 
700 1 |a Chen  |D Tzeng-Ji  |u Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan  |4 aut 
700 1 |a Perng  |D Diahn-Warng  |u Department of Chest Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, 112, Taipei, Taiwan  |4 aut 
700 1 |a Lee  |D Yu-Chin  |u Department of Chest Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, 112, Taipei, Taiwan  |4 aut 
700 1 |a Tzeng  |D Cheng-Hwai  |u Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan  |4 aut 
700 1 |a Chou  |D Kun-Ta  |u Department of Chest Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, 112, Taipei, Taiwan  |4 aut 
773 0 |t International Journal of Clinical Oncology  |d Springer Japan  |g 20/6(2015-12-01), 1244-1251  |x 1341-9625  |q 20:6<1244  |1 2015  |2 20  |o 10147 
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950 |B NATIONALLICENCE  |P 700  |E 1-  |a Su  |D Vincent  |u Department of Chest Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, 112, Taipei, Taiwan  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Liu  |D Chia-Jen  |u Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Hu  |D Yu-Wen  |u Cancer Center, Taipei Veterans General Hospital, Taipei, Taiwan  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Su  |D Wei-Juin  |u Department of Chest Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, 112, Taipei, Taiwan  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Chen  |D Yuh-Min  |u Department of Chest Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, 112, Taipei, Taiwan  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Lai  |D Shinn-Liang  |u Department of Chest Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, 112, Taipei, Taiwan  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Chen  |D Tzeng-Ji  |u Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Perng  |D Diahn-Warng  |u Department of Chest Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, 112, Taipei, Taiwan  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Lee  |D Yu-Chin  |u Department of Chest Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, 112, Taipei, Taiwan  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Tzeng  |D Cheng-Hwai  |u Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Chou  |D Kun-Ta  |u Department of Chest Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, 112, Taipei, Taiwan  |4 aut 
950 |B NATIONALLICENCE  |P 773  |E 0-  |t International Journal of Clinical Oncology  |d Springer Japan  |g 20/6(2015-12-01), 1244-1251  |x 1341-9625  |q 20:6<1244  |1 2015  |2 20  |o 10147