caa a22 4500 605490627 CHVBK 20210128100505.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s10147-015-0849-9 doi (NATIONALLICENCE)springer-10.1007/s10147-015-0849-9 Amyloidosis and the risk of cancer: a nationwide population-based study [Elektronische Daten] [Vincent Su, Chia-Jen Liu, Yu-Wen Hu, Wei-Juin Su, Yuh-Min Chen, Shinn-Liang Lai, Tzeng-Ji Chen, Diahn-Warng Perng, Yu-Chin Lee, Cheng-Hwai Tzeng, Kun-Ta Chou] Background: The association between amyloidosis and cancer remains unclear. Participants and methods: Using the Taiwan National Health Insurance Research Database we conducted a population-based cohort study. Patients newly diagnosed with amyloidosis between 1997 and 2009 were enrolled. Patients with antecedent cancer were excluded. Standardized incidence ratios (SIR) of cancers were calculated for the study cohort and compared with cancer incidence among the general population. We used a multivariate Cox regression model to evaluate the predictors of cancer development for patients with amyloidosis. Results: The study included 1,693 subjects with median follow-up of 5.63years. A total of 68 patients developed cancer. The incidence of kidney cancer (SIR 3.42; 95% CI 1.11-7.97; p=0.034) and hematologic malignancies (SIR 3.88; 95% CI 1.86-7.14; p<0.001) were significantly higher for patients with amyloidosis. Conclusion: This is currently the largest study to evaluate cancer risk among patients with amyloidosis. The results indicate that amyloidosis may be associated with an increased risk of kidney cancer and hematologic malignancies. Japan Society of Clinical Oncology, 2015 Amyloidosis nationallicence Cancer nationallicence Kidney cancer nationallicence Hematologic malignancies nationallicence Su Vincent Department of Chest Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, 112, Taipei, Taiwan aut Liu Chia-Jen Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan aut Hu Yu-Wen Cancer Center, Taipei Veterans General Hospital, Taipei, Taiwan aut Su Wei-Juin Department of Chest Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, 112, Taipei, Taiwan aut Chen Yuh-Min Department of Chest Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, 112, Taipei, Taiwan aut Lai Shinn-Liang Department of Chest Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, 112, Taipei, Taiwan aut Chen Tzeng-Ji Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan aut Perng Diahn-Warng Department of Chest Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, 112, Taipei, Taiwan aut Lee Yu-Chin Department of Chest Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, 112, Taipei, Taiwan aut Tzeng Cheng-Hwai Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan aut Chou Kun-Ta Department of Chest Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, 112, Taipei, Taiwan aut International Journal of Clinical Oncology Springer Japan 20/6(2015-12-01), 1244-1251 1341-9625 20:6<1244 2015 20 10147 https://doi.org/10.1007/s10147-015-0849-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10147-015-0849-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Su Vincent Department of Chest Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, 112, Taipei, Taiwan aut NATIONALLICENCE 700 1- Liu Chia-Jen Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Hu Yu-Wen Cancer Center, Taipei Veterans General Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Su Wei-Juin Department of Chest Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, 112, Taipei, Taiwan aut NATIONALLICENCE 700 1- Chen Yuh-Min Department of Chest Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, 112, Taipei, Taiwan aut NATIONALLICENCE 700 1- Lai Shinn-Liang Department of Chest Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, 112, Taipei, Taiwan aut NATIONALLICENCE 700 1- Chen Tzeng-Ji Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Perng Diahn-Warng Department of Chest Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, 112, Taipei, Taiwan aut NATIONALLICENCE 700 1- Lee Yu-Chin Department of Chest Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, 112, Taipei, Taiwan aut NATIONALLICENCE 700 1- Tzeng Cheng-Hwai Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Chou Kun-Ta Department of Chest Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, 112, Taipei, Taiwan aut NATIONALLICENCE 773 0- International Journal of Clinical Oncology Springer Japan 20/6(2015-12-01), 1244-1251 1341-9625 20:6<1244 2015 20 10147