caa a22 4500 605490651 CHVBK 20210128100506.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s10147-015-0827-2 doi (NATIONALLICENCE)springer-10.1007/s10147-015-0827-2 Efficacy of intraoperative entire-circumferential frozen section analysis of lumpectomy margins during breast-conserving surgery for breast cancer [Elektronische Daten] [Tomofumi Osako, Reiki Nishimura, Yasuyuki Nishiyama, Yasuhiro Okumura, Rumiko Tashima, Masahiro Nakano, Mamiko Fujisue, Yasuo Toyozumi, Nobuyuki Arima] Background: Intraoperative frozen section analysis of the surgical margins during breast-conserving surgery (BCS) for breast cancer can reliably achieve clear surgical margins and prevent re-operations. The aim of this study was to assess intraoperative entire-circumferential frozen section analysis (IEFSA) of the lumpectomy margins during BCS. Methods: A total of 1029 patients who underwent BCS with IEFSA between June 2007 and July 2013 were available for assessment. The inner surfaces of the shaved lumpectomy margins were examined as frozen sections during BCS. The margins were defined as positive when the cancer cells were present within 5mm from the edge of the outermost margins of the specimens. Results: Out of 1029 patients, 312 patients (30.3%) had positive margins after the initial lumpectomy and underwent additional resections during BCS. Fourteen patients (1.4%) underwent mastectomy following the results of additional resections during the first surgery. Of 1015 patients who completed BCS, 60 patients (5.9%) were found to have positive margins in the final pathology. One patient (0.1%) underwent re-operation after BCS while the residual diseases of the other 59 patients were judged to be minimal. Of the 312 patients who were judged to have positive margins after the initial lumpectomy with IEFSA, 53 patients (16.9%) were found to have negative margins in the final pathology. At a median follow-up time of 54.1months, one patient (0.1%) had a recurrence of breast cancer in the preserved breast. Conclusion: IEFSA is useful for preventing the need for re-operation and local recurrence after BCS. Japan Society of Clinical Oncology, 2015 Breast-conserving surgery nationallicence Lumpectomy margin nationallicence Intraoperative entire-circumferential frozen section analysis nationallicence Re-operation nationallicence Local recurrence nationallicence Osako Tomofumi Department of Breast and Endocrine Surgery, Kumamoto City Hospital, 1-1-60 Kotoh, Higashi-ku, 862-8605, Kumamoto, Japan aut Nishimura Reiki Department of Breast and Endocrine Surgery, Kumamoto City Hospital, 1-1-60 Kotoh, Higashi-ku, 862-8605, Kumamoto, Japan aut Nishiyama Yasuyuki Department of Breast and Endocrine Surgery, Kumamoto City Hospital, 1-1-60 Kotoh, Higashi-ku, 862-8605, Kumamoto, Japan aut Okumura Yasuhiro Department of Breast and Endocrine Surgery, Kumamoto City Hospital, 1-1-60 Kotoh, Higashi-ku, 862-8605, Kumamoto, Japan aut Tashima Rumiko Department of Breast and Endocrine Surgery, Kumamoto City Hospital, 1-1-60 Kotoh, Higashi-ku, 862-8605, Kumamoto, Japan aut Nakano Masahiro Department of Breast and Endocrine Surgery, Kumamoto City Hospital, 1-1-60 Kotoh, Higashi-ku, 862-8605, Kumamoto, Japan aut Fujisue Mamiko Department of Breast and Endocrine Surgery, Kumamoto City Hospital, 1-1-60 Kotoh, Higashi-ku, 862-8605, Kumamoto, Japan aut Toyozumi Yasuo Department of Pathology, Kumamoto City Hospital, 1-1-60 Kotoh, Higashi-ku, 862-8605, Kumamoto, Japan aut Arima Nobuyuki Department of Pathology, Kumamoto City Hospital, 1-1-60 Kotoh, Higashi-ku, 862-8605, Kumamoto, Japan aut International Journal of Clinical Oncology Springer Japan 20/6(2015-12-01), 1093-1101 1341-9625 20:6<1093 2015 20 10147 https://doi.org/10.1007/s10147-015-0827-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10147-015-0827-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Osako Tomofumi Department of Breast and Endocrine Surgery, Kumamoto City Hospital, 1-1-60 Kotoh, Higashi-ku, 862-8605, Kumamoto, Japan aut NATIONALLICENCE 700 1- Nishimura Reiki Department of Breast and Endocrine Surgery, Kumamoto City Hospital, 1-1-60 Kotoh, Higashi-ku, 862-8605, Kumamoto, Japan aut NATIONALLICENCE 700 1- Nishiyama Yasuyuki Department of Breast and Endocrine Surgery, Kumamoto City Hospital, 1-1-60 Kotoh, Higashi-ku, 862-8605, Kumamoto, Japan aut NATIONALLICENCE 700 1- Okumura Yasuhiro Department of Breast and Endocrine Surgery, Kumamoto City Hospital, 1-1-60 Kotoh, Higashi-ku, 862-8605, Kumamoto, Japan aut NATIONALLICENCE 700 1- Tashima Rumiko Department of Breast and Endocrine Surgery, Kumamoto City Hospital, 1-1-60 Kotoh, Higashi-ku, 862-8605, Kumamoto, Japan aut NATIONALLICENCE 700 1- Nakano Masahiro Department of Breast and Endocrine Surgery, Kumamoto City Hospital, 1-1-60 Kotoh, Higashi-ku, 862-8605, Kumamoto, Japan aut NATIONALLICENCE 700 1- Fujisue Mamiko Department of Breast and Endocrine Surgery, Kumamoto City Hospital, 1-1-60 Kotoh, Higashi-ku, 862-8605, Kumamoto, Japan aut NATIONALLICENCE 700 1- Toyozumi Yasuo Department of Pathology, Kumamoto City Hospital, 1-1-60 Kotoh, Higashi-ku, 862-8605, Kumamoto, Japan aut NATIONALLICENCE 700 1- Arima Nobuyuki Department of Pathology, Kumamoto City Hospital, 1-1-60 Kotoh, Higashi-ku, 862-8605, Kumamoto, Japan aut NATIONALLICENCE 773 0- International Journal of Clinical Oncology Springer Japan 20/6(2015-12-01), 1093-1101 1341-9625 20:6<1093 2015 20 10147