caa a22 4500 60549066X CHVBK 20210128100506.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s10147-015-0823-6 doi (NATIONALLICENCE)springer-10.1007/s10147-015-0823-6 Efficacy of palonosetron and 1-day dexamethasone in moderately emetogenic chemotherapy compared with fosaprepitant, granisetron, and dexamethasone: a prospective randomized crossover study [Elektronische Daten] [Hiromitsu Kitayama, Yasushi Tsuji, Junko Sugiyama, Ayako Doi, Tomohiro Kondo, Michiaki Hirayama] Background: Although palonosetron (PALO) and NK1 receptor antagonist both reduce chemotherapy-induced nausea and vomiting, no comparison trial in moderately emetogenic chemotherapy (MEC) had been reported. The purpose of this study was to find out which drug combinations are preferable for patients receiving MEC. Methods: Chemotherapy-naive patients receiving MEC were randomized to two groups; group A first received PALO therapy [PALO plus 1-day dexamethasone (DEX)], and group B first received fosaprepitant (FAPR) therapy [FAPR, granisetron (GRAN), and DEX]. Patients were re-allocated to the other therapy, respectively, for the second cycle of chemotherapy. We administered intravenous PALO (0.75mg) and DEX (9.9mg) to the PALO therapy group, and FAPR (150mg), DEX (4.95mg), and GRAN (3mg) to the FAPR therapy group, on Day 1. Complete response (CR) was the primary endpoint; complete control (CC), total control (CT), and the therapy chosen by the patients for their third and following cycles of antiemetic therapy were the secondary endpoints. We evaluated CR, CC, and TC in the acute phase, in the delayed phase, and over the whole period. Results: A total of 35 patients and 70 cycles of therapy was evaluable for analysis. No significant difference was found at all evaluation points. Overall CR rates for PALO and FAPR therapy were 74 vs 69% (P=0.567), CC rates 66 vs 69% (P=0.521), and TC rates 46 vs 60% (P=0.235), respectively. Patients also showed no clear preference for their third and following cycles of chemotherapy, choosing both regimens almost equally often (PALO 10 vs FAPR 13). Conclusions: PALO and 1-day DEX is almost equivalent to FAPR, GRAN, and DEX for MEC. Japan Society of Clinical Oncology, 2015 Chemotherapy-induced nausea and vomiting nationallicence Moderately emetogenic chemotherapy nationallicence Palonosetron nationallicence 1-Day dexamethasone nationallicence Fosaprepitant nationallicence Granisetron nationallicence Kitayama Hiromitsu Department of Medical Oncology, Tonan Hospital, Kita 1 Jo Nishi 6 Chome, Chuo-ku, 060-0001, Sapporo, Hokkaido, Japan aut Tsuji Yasushi Department of Medical Oncology, Tonan Hospital, Kita 1 Jo Nishi 6 Chome, Chuo-ku, 060-0001, Sapporo, Hokkaido, Japan aut Sugiyama Junko Department of Medical Oncology, Tonan Hospital, Kita 1 Jo Nishi 6 Chome, Chuo-ku, 060-0001, Sapporo, Hokkaido, Japan aut Doi Ayako Department of Medical Oncology, Tonan Hospital, Kita 1 Jo Nishi 6 Chome, Chuo-ku, 060-0001, Sapporo, Hokkaido, Japan aut Kondo Tomohiro Department of Medical Oncology, Tonan Hospital, Kita 1 Jo Nishi 6 Chome, Chuo-ku, 060-0001, Sapporo, Hokkaido, Japan aut Hirayama Michiaki Department of Gastroenterological Medicine, Tonan Hospital, Hokkaido, Japan aut International Journal of Clinical Oncology Springer Japan 20/6(2015-12-01), 1051-1056 1341-9625 20:6<1051 2015 20 10147 https://doi.org/10.1007/s10147-015-0823-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10147-015-0823-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kitayama Hiromitsu Department of Medical Oncology, Tonan Hospital, Kita 1 Jo Nishi 6 Chome, Chuo-ku, 060-0001, Sapporo, Hokkaido, Japan aut NATIONALLICENCE 700 1- Tsuji Yasushi Department of Medical Oncology, Tonan Hospital, Kita 1 Jo Nishi 6 Chome, Chuo-ku, 060-0001, Sapporo, Hokkaido, Japan aut NATIONALLICENCE 700 1- Sugiyama Junko Department of Medical Oncology, Tonan Hospital, Kita 1 Jo Nishi 6 Chome, Chuo-ku, 060-0001, Sapporo, Hokkaido, Japan aut NATIONALLICENCE 700 1- Doi Ayako Department of Medical Oncology, Tonan Hospital, Kita 1 Jo Nishi 6 Chome, Chuo-ku, 060-0001, Sapporo, Hokkaido, Japan aut NATIONALLICENCE 700 1- Kondo Tomohiro Department of Medical Oncology, Tonan Hospital, Kita 1 Jo Nishi 6 Chome, Chuo-ku, 060-0001, Sapporo, Hokkaido, Japan aut NATIONALLICENCE 700 1- Hirayama Michiaki Department of Gastroenterological Medicine, Tonan Hospital, Hokkaido, Japan aut NATIONALLICENCE 773 0- International Journal of Clinical Oncology Springer Japan 20/6(2015-12-01), 1051-1056 1341-9625 20:6<1051 2015 20 10147