Leiomyosarcoma: investigation of prognostic factors for risk-stratification model
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| 024 | 7 | 0 | |a 10.1007/s10147-015-0847-y |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10147-015-0847-y | ||
| 245 | 0 | 0 | |a Leiomyosarcoma: investigation of prognostic factors for risk-stratification model |h [Elektronische Daten] |c [Hyun Kim, Yong Cho, Soo Kim, Sun Rha, Joong Ahn, Woo Yang, Young Lee, Jin-Suck Suh, Jae Roh, Kyung Kim, Young Choi, Kyoo-Ho Shin, Hyo Kim] |
| 520 | 3 | |a Background: We performed this study to define distinctive clinical features of leiomyosarcoma by assessing prognostic factors. Methods: Between 1988 and 2011, 129 leiomyosarcoma patients who underwent surgical resection with curative intent were retrospectively reviewed. Results: Of the 129 leiomyosarcoma patients, the distribution of anatomic locations was: extremity (n=25), pelvis (n=40), thoracic cavity (n=11), intra-abdomen (n=19), retroperitoneum (n=23), and head/neck (n=11). We classified the anatomic locations into two categories as abdominal (intra-abdomen and retroperitoneum, n=42) and extra-abdominal (extremity, pelvis, thoracic cavity, and head/neck, n=87). Prognosis was worse for the abdominal group than for the extra-abdominal group (median DFS 2.9 9.0years, P=0.04). Similarly, overall survival (OS) was also significantly worse for abdominal group (P=0.027). Independent prognostic factors for survival were primary site (P=0.041, hazard ratio (HR) 1.7; 95% CI 1.2-2.8), tumor size (P=0.038, HR 1.9; 95% CI1.13-3.38), margin status (P=0.019, HR 2.1; 95% CI1.13-3.88), and histology grade (P=0.01, HR 3.59; 95% CI 1.64-7.87). We identified four different risk groups with different survival outcome: group 1 (n=8), no adverse factors; groups 2 (n=37) and 3 (n=61) with one and two adverse factors, and group 4 (n=23) with 3 or 4 adverse factors. Conclusion: Primary site, tumor size, resection margin, and histology subtype were independently associated with survival outcome. A prognostic model for leiomyosarcoma patients revealed four distinct groups of patients with good prognostic discrimination. | |
| 540 | |a Japan Society of Clinical Oncology, 2015 | ||
| 690 | 7 | |a Leiomyosarcoma |2 nationallicence | |
| 690 | 7 | |a Prognostic factors |2 nationallicence | |
| 690 | 7 | |a Risk stratification model |2 nationallicence | |
| 700 | 1 | |a Kim |D Hyun |u Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-Gu, 120-752, Seoul, Korea |4 aut | |
| 700 | 1 | |a Cho |D Yong |u Department of Orthopaedic Surgery, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-Gu, 120-752, Seoul, Korea |4 aut | |
| 700 | 1 | |a Kim |D Soo |u Department of Pathology, Yonsei University College of Medicine, Seoul, Korea |4 aut | |
| 700 | 1 | |a Rha |D Sun |u Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-Gu, 120-752, Seoul, Korea |4 aut | |
| 700 | 1 | |a Ahn |D Joong |u Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-Gu, 120-752, Seoul, Korea |4 aut | |
| 700 | 1 | |a Yang |D Woo |u Department of Pathology, Yonsei University College of Medicine, Seoul, Korea |4 aut | |
| 700 | 1 | |a Lee |D Young |u Department of Radiology, Yonsei University College of Medicine, Seoul, Korea |4 aut | |
| 700 | 1 | |a Suh |D Jin-Suck |u Department of Radiology, Yonsei University College of Medicine, Seoul, Korea |4 aut | |
| 700 | 1 | |a Roh |D Jae |u Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-Gu, 120-752, Seoul, Korea |4 aut | |
| 700 | 1 | |a Kim |D Kyung |u Department of Surgery, Yonsei University College of Medicine, Seoul, Korea |4 aut | |
| 700 | 1 | |a Choi |D Young |u Department of Urology, Yonsei University College of Medicine, Seoul, Korea |4 aut | |
| 700 | 1 | |a Shin |D Kyoo-Ho |u Department of Orthopaedic Surgery, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-Gu, 120-752, Seoul, Korea |4 aut | |
| 700 | 1 | |a Kim |D Hyo |u Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-Gu, 120-752, Seoul, Korea |4 aut | |
| 773 | 0 | |t International Journal of Clinical Oncology |d Springer Japan |g 20/6(2015-12-01), 1226-1232 |x 1341-9625 |q 20:6<1226 |1 2015 |2 20 |o 10147 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10147-015-0847-y |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10147-015-0847-y |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kim |D Hyun |u Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-Gu, 120-752, Seoul, Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Cho |D Yong |u Department of Orthopaedic Surgery, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-Gu, 120-752, Seoul, Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kim |D Soo |u Department of Pathology, Yonsei University College of Medicine, Seoul, Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Rha |D Sun |u Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-Gu, 120-752, Seoul, Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ahn |D Joong |u Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-Gu, 120-752, Seoul, Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yang |D Woo |u Department of Pathology, Yonsei University College of Medicine, Seoul, Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lee |D Young |u Department of Radiology, Yonsei University College of Medicine, Seoul, Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Suh |D Jin-Suck |u Department of Radiology, Yonsei University College of Medicine, Seoul, Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Roh |D Jae |u Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-Gu, 120-752, Seoul, Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kim |D Kyung |u Department of Surgery, Yonsei University College of Medicine, Seoul, Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Choi |D Young |u Department of Urology, Yonsei University College of Medicine, Seoul, Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Shin |D Kyoo-Ho |u Department of Orthopaedic Surgery, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-Gu, 120-752, Seoul, Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kim |D Hyo |u Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-Gu, 120-752, Seoul, Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t International Journal of Clinical Oncology |d Springer Japan |g 20/6(2015-12-01), 1226-1232 |x 1341-9625 |q 20:6<1226 |1 2015 |2 20 |o 10147 | ||