caa a22 4500 605490724 CHVBK 20210128100506.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s10147-015-0847-y doi (NATIONALLICENCE)springer-10.1007/s10147-015-0847-y Leiomyosarcoma: investigation of prognostic factors for risk-stratification model [Elektronische Daten] [Hyun Kim, Yong Cho, Soo Kim, Sun Rha, Joong Ahn, Woo Yang, Young Lee, Jin-Suck Suh, Jae Roh, Kyung Kim, Young Choi, Kyoo-Ho Shin, Hyo Kim] Background: We performed this study to define distinctive clinical features of leiomyosarcoma by assessing prognostic factors. Methods: Between 1988 and 2011, 129 leiomyosarcoma patients who underwent surgical resection with curative intent were retrospectively reviewed. Results: Of the 129 leiomyosarcoma patients, the distribution of anatomic locations was: extremity (n=25), pelvis (n=40), thoracic cavity (n=11), intra-abdomen (n=19), retroperitoneum (n=23), and head/neck (n=11). We classified the anatomic locations into two categories as abdominal (intra-abdomen and retroperitoneum, n=42) and extra-abdominal (extremity, pelvis, thoracic cavity, and head/neck, n=87). Prognosis was worse for the abdominal group than for the extra-abdominal group (median DFS 2.9 9.0years, P=0.04). Similarly, overall survival (OS) was also significantly worse for abdominal group (P=0.027). Independent prognostic factors for survival were primary site (P=0.041, hazard ratio (HR) 1.7; 95% CI 1.2-2.8), tumor size (P=0.038, HR 1.9; 95% CI1.13-3.38), margin status (P=0.019, HR 2.1; 95% CI1.13-3.88), and histology grade (P=0.01, HR 3.59; 95% CI 1.64-7.87). We identified four different risk groups with different survival outcome: group 1 (n=8), no adverse factors; groups 2 (n=37) and 3 (n=61) with one and two adverse factors, and group 4 (n=23) with 3 or 4 adverse factors. Conclusion: Primary site, tumor size, resection margin, and histology subtype were independently associated with survival outcome. A prognostic model for leiomyosarcoma patients revealed four distinct groups of patients with good prognostic discrimination. Japan Society of Clinical Oncology, 2015 Leiomyosarcoma nationallicence Prognostic factors nationallicence Risk stratification model nationallicence Kim Hyun Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-Gu, 120-752, Seoul, Korea aut Cho Yong Department of Orthopaedic Surgery, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-Gu, 120-752, Seoul, Korea aut Kim Soo Department of Pathology, Yonsei University College of Medicine, Seoul, Korea aut Rha Sun Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-Gu, 120-752, Seoul, Korea aut Ahn Joong Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-Gu, 120-752, Seoul, Korea aut Yang Woo Department of Pathology, Yonsei University College of Medicine, Seoul, Korea aut Lee Young Department of Radiology, Yonsei University College of Medicine, Seoul, Korea aut Suh Jin-Suck Department of Radiology, Yonsei University College of Medicine, Seoul, Korea aut Roh Jae Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-Gu, 120-752, Seoul, Korea aut Kim Kyung Department of Surgery, Yonsei University College of Medicine, Seoul, Korea aut Choi Young Department of Urology, Yonsei University College of Medicine, Seoul, Korea aut Shin Kyoo-Ho Department of Orthopaedic Surgery, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-Gu, 120-752, Seoul, Korea aut Kim Hyo Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-Gu, 120-752, Seoul, Korea aut International Journal of Clinical Oncology Springer Japan 20/6(2015-12-01), 1226-1232 1341-9625 20:6<1226 2015 20 10147 https://doi.org/10.1007/s10147-015-0847-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10147-015-0847-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kim Hyun Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-Gu, 120-752, Seoul, Korea aut NATIONALLICENCE 700 1- Cho Yong Department of Orthopaedic Surgery, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-Gu, 120-752, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Soo Department of Pathology, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Rha Sun Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-Gu, 120-752, Seoul, Korea aut NATIONALLICENCE 700 1- Ahn Joong Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-Gu, 120-752, Seoul, Korea aut NATIONALLICENCE 700 1- Yang Woo Department of Pathology, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Young Department of Radiology, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Suh Jin-Suck Department of Radiology, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Roh Jae Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-Gu, 120-752, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Kyung Department of Surgery, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Choi Young Department of Urology, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Shin Kyoo-Ho Department of Orthopaedic Surgery, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-Gu, 120-752, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Hyo Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-Gu, 120-752, Seoul, Korea aut NATIONALLICENCE 773 0- International Journal of Clinical Oncology Springer Japan 20/6(2015-12-01), 1226-1232 1341-9625 20:6<1226 2015 20 10147