caa a22 4500 605490805 CHVBK 20210128100506.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s10147-014-0741-z doi (NATIONALLICENCE)springer-10.1007/s10147-014-0741-z Comparison of therapeutic results from radiofrequency ablation and stereotactic body radiotherapy in solitary lung tumors measuring 5cm or smaller [Elektronische Daten] [Satoru Ochiai, Koichiro Yamakado, Hiroshi Kodama, Yoshihito Nomoto, Noriko Ii, Haruyuki Takaki, Hajime Sakuma] Backgrounds: This retrospective study was conducted to compare the clinical outcomes of radiofrequency ablation (RFA) with those of stereotactic body radiotherapy (SBRT) in patients with lung tumors. Methods: Local tumor progression, adverse events, and overall survival were compared in patients who underwent either RFA or SBRT for a single lung tumor measuring 5cm or smaller. This study was approved by the institutional review boards of two institutions. Informed consent was waived. Results: During September 2009 to June 2012, 48 patients [30 males and 18 females, with a mean age±standard deviation (SD) of 75.0±7.5years] underwent RFA at one institution and 47 patients (21 males and 26 females, with a mean age±SD of 77.0±7.5years) underwent SBRT in another. The mean maximum tumor diameter±SD was 2.0±0.8cm (range 0.6−3.9cm) in the RFA group, and 2.1±0.9cm (range 0.8-4.7cm, p=0.539) in the SBRT group. The RFA and SBRT groups showed similar 3-year local tumor progression [9.6%, 95% confidence interval (CI) 3.6-23.9% vs. 7.0%, 95% CI 0.2-20.2%, p=0.746] and overall survival rates (86.4%, 95% CI 69.2-94.3% vs. 79.6%, 95% CI 60.6-90.1%, p=0.738). No factor significantly affected local tumor progression. A maximum tumor size of 2cm was identified as a prognostic factor in both univariate and multivariate analyses. No death was related to treatment procedures. Major complication rates (Grade 3 adverse events) of the RFA (10.4%, 5/48) and SBRT (8.5%, 4/47, p>0.999) groups were similar. Conclusion: For lung tumor patients, lung RFA provided local tumor control and survival that were similar to those achieved using SBRT, with equal safety. Japan Society of Clinical Oncology, 2014 Lung tumors nationallicence Radiofrequency ablation nationallicence Stereotactic body radiotherapy nationallicence Prognosis nationallicence Complication nationallicence Ochiai Satoru Department of Radiation Oncology, Matsusaka Central Hospital, 102 Kobou Kawaimachi, 515-8566, Matsusaka, Mie, Japan aut Yamakado Koichiro Department of Radiology, Mie University School of Medicine, 2-174 Edobashi, 514-8507, Tsu, Mie, Japan aut Kodama Hiroshi Department of Radiology, Suzuka Central Hospital, 1275-53 Yamanohana Yasuduka-cho, 513-0818, Suzuka, Mie, Japan aut Nomoto Yoshihito Department of Radiology, Mie University School of Medicine, 2-174 Edobashi, 514-8507, Tsu, Mie, Japan aut Ii Noriko Department of Radiology, Mie University School of Medicine, 2-174 Edobashi, 514-8507, Tsu, Mie, Japan aut Takaki Haruyuki Department of Radiology, Mie University School of Medicine, 2-174 Edobashi, 514-8507, Tsu, Mie, Japan aut Sakuma Hajime Department of Radiology, Mie University School of Medicine, 2-174 Edobashi, 514-8507, Tsu, Mie, Japan aut International Journal of Clinical Oncology Springer Japan 20/3(2015-06-01), 499-507 1341-9625 20:3<499 2015 20 10147 https://doi.org/10.1007/s10147-014-0741-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10147-014-0741-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ochiai Satoru Department of Radiation Oncology, Matsusaka Central Hospital, 102 Kobou Kawaimachi, 515-8566, Matsusaka, Mie, Japan aut NATIONALLICENCE 700 1- Yamakado Koichiro Department of Radiology, Mie University School of Medicine, 2-174 Edobashi, 514-8507, Tsu, Mie, Japan aut NATIONALLICENCE 700 1- Kodama Hiroshi Department of Radiology, Suzuka Central Hospital, 1275-53 Yamanohana Yasuduka-cho, 513-0818, Suzuka, Mie, Japan aut NATIONALLICENCE 700 1- Nomoto Yoshihito Department of Radiology, Mie University School of Medicine, 2-174 Edobashi, 514-8507, Tsu, Mie, Japan aut NATIONALLICENCE 700 1- Ii Noriko Department of Radiology, Mie University School of Medicine, 2-174 Edobashi, 514-8507, Tsu, Mie, Japan aut NATIONALLICENCE 700 1- Takaki Haruyuki Department of Radiology, Mie University School of Medicine, 2-174 Edobashi, 514-8507, Tsu, Mie, Japan aut NATIONALLICENCE 700 1- Sakuma Hajime Department of Radiology, Mie University School of Medicine, 2-174 Edobashi, 514-8507, Tsu, Mie, Japan aut NATIONALLICENCE 773 0- International Journal of Clinical Oncology Springer Japan 20/3(2015-06-01), 499-507 1341-9625 20:3<499 2015 20 10147