caa a22 4500 605490813 CHVBK 20210128100506.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s10147-014-0729-8 doi (NATIONALLICENCE)springer-10.1007/s10147-014-0729-8 The prognosis of osteosarcoma occurring as second malignancy of childhood cancers may be favorable: experience of two cancer centers in Japan [Elektronische Daten] [Tsukasa Yonemoto, Ako Hosono, Shintaro Iwata, Hiroto Kamoda, Yoko Hagiwara, Tomohiro Fujiwara, Akira Kawai, Takeshi Ishii] Background: Osteosarcoma as second malignancy of childhood cancers rarely occurs, and its clinical characteristics are unclear. Methods: Patients with osteosarcoma occurring as second malignancy of childhood cancers were retrospectively surveyed. Results: Of 323 patients with osteosarcoma registered in the database, 10 (3.1%) had a past history of childhood cancers. The mean age at the onset of the first childhood cancer was 2.7years, and the diagnosis of the first childhood cancer was adrenocortical carcinoma, malignant teratoma, ovarian carcinoma, Ewing's sarcoma, and rhabdomyosarcoma in 1 patient each, and retinoblastoma in 5 patients. Osteosarcoma as second malignancy occurred 14.6years after the first childhood cancer on average. Seven patients were alive and 3 died. In 1 patient, the cause of death was related to a complication of treatment for the first childhood cancer. Except for this patient, 7 (77.8%) of 9 patients survived with no disease (mean follow-up period: 10.9years). Conclusions: Attention should be paid to complications of treatment for the first childhood cancer in the treatment for osteosarcoma occurring as second malignancy. The prognosis of osteosarcoma as second malignancy of childhood cancers may be more favorable than that of conventional osteosarcoma. Japan Society of Clinical Oncology, 2014 Osteosarcoma nationallicence Second malignant neoplasm nationallicence Childhood cancer nationallicence Multiple primary cancers nationallicence Yonemoto Tsukasa Division of Orthopaedic Surgery, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, 260-8717, Chiba, Japan aut Hosono Ako Division of Pediatrics, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan aut Iwata Shintaro Division of Orthopaedic Surgery, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, 260-8717, Chiba, Japan aut Kamoda Hiroto Division of Orthopaedic Surgery, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, 260-8717, Chiba, Japan aut Hagiwara Yoko Division of Orthopaedic Surgery, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, 260-8717, Chiba, Japan aut Fujiwara Tomohiro Division of Musculoskeletal Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan aut Kawai Akira Division of Musculoskeletal Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan aut Ishii Takeshi Division of Orthopaedic Surgery, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, 260-8717, Chiba, Japan aut International Journal of Clinical Oncology Springer Japan 20/3(2015-06-01), 613-616 1341-9625 20:3<613 2015 20 10147 https://doi.org/10.1007/s10147-014-0729-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10147-014-0729-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yonemoto Tsukasa Division of Orthopaedic Surgery, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, 260-8717, Chiba, Japan aut NATIONALLICENCE 700 1- Hosono Ako Division of Pediatrics, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan aut NATIONALLICENCE 700 1- Iwata Shintaro Division of Orthopaedic Surgery, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, 260-8717, Chiba, Japan aut NATIONALLICENCE 700 1- Kamoda Hiroto Division of Orthopaedic Surgery, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, 260-8717, Chiba, Japan aut NATIONALLICENCE 700 1- Hagiwara Yoko Division of Orthopaedic Surgery, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, 260-8717, Chiba, Japan aut NATIONALLICENCE 700 1- Fujiwara Tomohiro Division of Musculoskeletal Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan aut NATIONALLICENCE 700 1- Kawai Akira Division of Musculoskeletal Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan aut NATIONALLICENCE 700 1- Ishii Takeshi Division of Orthopaedic Surgery, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, 260-8717, Chiba, Japan aut NATIONALLICENCE 773 0- International Journal of Clinical Oncology Springer Japan 20/3(2015-06-01), 613-616 1341-9625 20:3<613 2015 20 10147