caa a22 4500 605490821 CHVBK 20210128100506.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s10147-014-0743-x doi (NATIONALLICENCE)springer-10.1007/s10147-014-0743-x Cates Justin Department of Pathology, Vanderbilt University Medical Center, Medical Center North, CC-3322, 1161 21st Ave. South, 37232, Nashville, TN, USA aut Pregnancy does not increase the local recurrence rate after surgical resection of desmoid-type fibromatosis [Elektronische Daten] [Justin. Cates] Background: Pregnancy has been reported as a risk factor for promoting growth and progression of desmoid-type fibromatosis because of the presumed role of estrogens in stimulating desmoid growth. In this study, the clinical outcomes of females who were pregnant 5years or less before resection of desmoid tumor or who became pregnant after resection were compared to nulliparous females or females who were pregnant more than 5years before resection. Methods: Obstetric histories of desmoid tumor patients were abstracted from medical records. Patients were grouped by pregnancy status as either: pregnancy-associated (pregnant up to 5years before primary desmoid tumor resection or pregnant after resection) or not pregnancy-associated (nulliparous or pregnant more than 5years before resection of desmoid tumor). Cox proportional hazards regression was used to evaluate pregnancy status as a predictor of desmoid tumor recurrence. Results: There were 15 females who had pregnancy-associated desmoids (33%) and 31 females who had non-pregnancy-associated desmoids (67%). There were no differences in clinicopathologic features or recurrence-free survival between females of different pregnancy status in univariate or multivariate survival analyses. Conclusion: Recurrence-free survival rates among women recently pregnant before or pregnant after resection of desmoid tumor and nulliparous women or those with a remote history of pregnancy are comparable after adjusting for patient age, anatomic location, and completeness of surgical resection. Subsequent pregnancy should not be discouraged for reproductive-aged women after resection of desmoid-type fibromatosis. Japan Society of Clinical Oncology, 2014 Fibromatosis nationallicence Aggressive nationallicence Pregnancy nationallicence Estrogens nationallicence Neoplasm recurrence nationallicence Local nationallicence Prognosis nationallicence International Journal of Clinical Oncology Springer Japan 20/3(2015-06-01), 617-622 1341-9625 20:3<617 2015 20 10147 https://doi.org/10.1007/s10147-014-0743-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10147-014-0743-x text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Cates Justin Department of Pathology, Vanderbilt University Medical Center, Medical Center North, CC-3322, 1161 21st Ave. South, 37232, Nashville, TN, USA aut NATIONALLICENCE 773 0- International Journal of Clinical Oncology Springer Japan 20/3(2015-06-01), 617-622 1341-9625 20:3<617 2015 20 10147