caa a22 4500 60549102X CHVBK 20210128100508.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s10147-015-0826-3 doi (NATIONALLICENCE)springer-10.1007/s10147-015-0826-3 Current therapeutic strategies for multiple myeloma [Elektronische Daten] [Yoshihiro Torimoto, Motohiro Shindo, Katsuya Ikuta, Yutaka Kohgo] The introduction of novel molecular targeting agents against multiple myeloma has dramatically and rapidly changed the therapeutic strategies for this incurable hematologic disease. Novel agents such as thalidomide, bortezomib and lenalidomide have significantly improved the response rate, progression-free survival, and overall survival compared with conventional chemotherapies, and made it easy to control the disease for longer periods of time. Initial therapies for newly diagnosed myeloma patients depend on the individual's clinical condition. Induction therapy with novel agents and high-dose chemotherapy followed by autologous stem cell transplantation is a standard therapy for newly diagnosed younger myeloma patients. On the other hand, several combinations of novel agents and other drugs (melphalan, prednisone, dexamethasone, etc.) are widely used as initial therapy for transplantation-ineligible myeloma patients. Although the clinical advantage of maintenance therapy after induction therapy has been reported, it is not recommend in routine practice. Maintenance therapy would be an option for some patients. Despite the significant improvements with the use of novel agents, the majority of patients eventually relapse. A number of treatment options including novel agents, which demonstrated marked clinical effects, are reported in the setting of salvage therapy. The choice of appropriate therapy for relapsed or refractory patients must take the disease status or patient status in consideration. Furthermore, a new generation of novel agents such as pomalidomide, carfilzomib or panobinostat has recently become available for relapsed or refractory myeloma. It is necessary to determine the optimal combination of drugs, administration timing and patients to be treated in future clinical trials. Japan Society of Clinical Oncology, 2015 Multiple myeloma nationallicence Autologous stem cell transplantation nationallicence Immunomodulatory agents nationallicence Proteasome inhibitors nationallicence Histone deacetylase inhibitors nationallicence Torimoto Yoshihiro Oncology Center, Asahikawa Medical University Hospital, 2-1, Midorigaoka-Higashi, 078-8510, Asahikawa, Hokkaido, Japan aut Shindo Motohiro Division of Gastroenterology and Hematology/Oncology, Department on Internal Medicine, Asahikawa Medical University, 2-1, Midorigaoka-Higashi, 078-8510, Asahikawa, Hokkaido, Japan aut Ikuta Katsuya Division of Gastroenterology and Hematology/Oncology, Department on Internal Medicine, Asahikawa Medical University, 2-1, Midorigaoka-Higashi, 078-8510, Asahikawa, Hokkaido, Japan aut Kohgo Yutaka Division of Gastroenterology and Hematology/Oncology, Department on Internal Medicine, Asahikawa Medical University, 2-1, Midorigaoka-Higashi, 078-8510, Asahikawa, Hokkaido, Japan aut International Journal of Clinical Oncology Springer Japan 20/3(2015-06-01), 423-430 1341-9625 20:3<423 2015 20 10147 https://doi.org/10.1007/s10147-015-0826-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10147-015-0826-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Torimoto Yoshihiro Oncology Center, Asahikawa Medical University Hospital, 2-1, Midorigaoka-Higashi, 078-8510, Asahikawa, Hokkaido, Japan aut NATIONALLICENCE 700 1- Shindo Motohiro Division of Gastroenterology and Hematology/Oncology, Department on Internal Medicine, Asahikawa Medical University, 2-1, Midorigaoka-Higashi, 078-8510, Asahikawa, Hokkaido, Japan aut NATIONALLICENCE 700 1- Ikuta Katsuya Division of Gastroenterology and Hematology/Oncology, Department on Internal Medicine, Asahikawa Medical University, 2-1, Midorigaoka-Higashi, 078-8510, Asahikawa, Hokkaido, Japan aut NATIONALLICENCE 700 1- Kohgo Yutaka Division of Gastroenterology and Hematology/Oncology, Department on Internal Medicine, Asahikawa Medical University, 2-1, Midorigaoka-Higashi, 078-8510, Asahikawa, Hokkaido, Japan aut NATIONALLICENCE 773 0- International Journal of Clinical Oncology Springer Japan 20/3(2015-06-01), 423-430 1341-9625 20:3<423 2015 20 10147