Efficacy and feasibility of docetaxel, cisplatin, and 5-fluorouracil induction chemotherapy for locally advanced head and neck squamous cell carcinoma classified as clinical nodal stage N2c, N3, or N2b with supraclavicular lymph node metastases
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| 024 | 7 | 0 | |a 10.1007/s10147-014-0749-4 |2 doi |
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| 245 | 0 | 0 | |a Efficacy and feasibility of docetaxel, cisplatin, and 5-fluorouracil induction chemotherapy for locally advanced head and neck squamous cell carcinoma classified as clinical nodal stage N2c, N3, or N2b with supraclavicular lymph node metastases |h [Elektronische Daten] |c [Naoki Izawa, Yusuke Onozawa, Tomomi Hikosaka, Satoshi Hamauchi, Takahiro Tsushima, Akiko Todaka, Nozomu Machida, Yutaka Haraguchi, Hirofumi Ogawa, Tetsuo Nishimura, Masahiro Nakagawa, Tomohito Fuke, Yoshiyuki Iida, Tomoyuki Kamijo, Tetsuro Onitsuka, Narikazu Boku, Hirofumi Yasui, Tomoya Yokota] |
| 520 | 3 | |a Background: We evaluated the efficacy and feasibility of docetaxel, cisplatin, and 5-fluorouracil (TPF) induction chemotherapy followed by concurrent chemoradiotherapy (CRT) for locally advanced head and neck squamous cell carcinoma (HNSCC) with a high risk of distant metastases compared with CRT alone. Methods: We retrospectively analyzed 29 HNSCC patients with clinical nodal stage N2c, N3, or N2b disease and supraclavicular lymph node metastases receiving CRT alone (CRT group; n=16) or TPF induction chemotherapy followed by CRT (TPF group; n=13) between April 2008 and May 2012. Results: The median follow-up periods were 14.5 (range 5.0-65.0) and 25.0(range 14.0-32.0) months for CRT and TPF groups, respectively. A greater proportion of patient characteristics in the CRT group had advanced T and N stages. The overall response rate to induction TPF was 50.0%; grade 3-4 toxicities included neutropenia, febrile neutropenia, anorexia, and hyponatremia. Complete response rates after CRT completion were 55.5% in the TPF and 42.9% in the CRT group; median overall survival was not reached in the TPF group and was 14.0months in the CRT group (p=0.037). Multivariate analysis revealed that induction TPF and T stage were independent prognostic factors [hazard ratio (HR)=0.196; 95% confidence interval (CI) 0.043-0.898; p=0.036, HR=9.966; 95% CI 2.270-43.75; p=0.002, respectively). Conclusion: TPF followed by CRT is tolerated and may be an option for the treatment of locally advanced stage N2c, N3, or N2b HNSCC. | |
| 540 | |a Japan Society of Clinical Oncology, 2014 | ||
| 690 | 7 | |a TPF |2 nationallicence | |
| 690 | 7 | |a Induction chemotherapy |2 nationallicence | |
| 690 | 7 | |a Chemoradiotherapy |2 nationallicence | |
| 700 | 1 | |a Izawa |D Naoki |u Division of Gastrointestinal Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi Sunto-gun, 411-8777, Shizuoka, Japan |4 aut | |
| 700 | 1 | |a Onozawa |D Yusuke |u Division of Gastrointestinal Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi Sunto-gun, 411-8777, Shizuoka, Japan |4 aut | |
| 700 | 1 | |a Hikosaka |D Tomomi |u Division of Gastrointestinal Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi Sunto-gun, 411-8777, Shizuoka, Japan |4 aut | |
| 700 | 1 | |a Hamauchi |D Satoshi |u Division of Gastrointestinal Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi Sunto-gun, 411-8777, Shizuoka, Japan |4 aut | |
| 700 | 1 | |a Tsushima |D Takahiro |u Division of Gastrointestinal Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi Sunto-gun, 411-8777, Shizuoka, Japan |4 aut | |
| 700 | 1 | |a Todaka |D Akiko |u Division of Gastrointestinal Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi Sunto-gun, 411-8777, Shizuoka, Japan |4 aut | |
| 700 | 1 | |a Machida |D Nozomu |u Division of Gastrointestinal Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi Sunto-gun, 411-8777, Shizuoka, Japan |4 aut | |
| 700 | 1 | |a Haraguchi |D Yutaka |u Division of Gastrointestinal Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi Sunto-gun, 411-8777, Shizuoka, Japan |4 aut | |
| 700 | 1 | |a Ogawa |D Hirofumi |u Division of Radiation Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi Sunto-gun, 411-8777, Shizuoka, Japan |4 aut | |
| 700 | 1 | |a Nishimura |D Tetsuo |u Division of Radiation Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi Sunto-gun, 411-8777, Shizuoka, Japan |4 aut | |
| 700 | 1 | |a Nakagawa |D Masahiro |u Division of Plastic and Reconstructive Surgery, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi Sunto-gun, 411-8777, Shizuoka, Japan |4 aut | |
| 700 | 1 | |a Fuke |D Tomohito |u Division of Head and Neck Surgery, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi Sunto-gun, 411-8777, Shizuoka, Japan |4 aut | |
| 700 | 1 | |a Iida |D Yoshiyuki |u Division of Head and Neck Surgery, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi Sunto-gun, 411-8777, Shizuoka, Japan |4 aut | |
| 700 | 1 | |a Kamijo |D Tomoyuki |u Division of Head and Neck Surgery, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi Sunto-gun, 411-8777, Shizuoka, Japan |4 aut | |
| 700 | 1 | |a Onitsuka |D Tetsuro |u Division of Head and Neck Surgery, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi Sunto-gun, 411-8777, Shizuoka, Japan |4 aut | |
| 700 | 1 | |a Boku |D Narikazu |u Division of Clinical Oncology, St. Marianna University School of Medicine, 2-16-1 Sugao Miyamae-ku, 216-8511, Kawasaki, Japan |4 aut | |
| 700 | 1 | |a Yasui |D Hirofumi |u Division of Gastrointestinal Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi Sunto-gun, 411-8777, Shizuoka, Japan |4 aut | |
| 700 | 1 | |a Yokota |D Tomoya |u Division of Gastrointestinal Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi Sunto-gun, 411-8777, Shizuoka, Japan |4 aut | |
| 773 | 0 | |t International Journal of Clinical Oncology |d Springer Japan |g 20/3(2015-06-01), 455-462 |x 1341-9625 |q 20:3<455 |1 2015 |2 20 |o 10147 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10147-014-0749-4 |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10147-014-0749-4 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Izawa |D Naoki |u Division of Gastrointestinal Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi Sunto-gun, 411-8777, Shizuoka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Onozawa |D Yusuke |u Division of Gastrointestinal Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi Sunto-gun, 411-8777, Shizuoka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hikosaka |D Tomomi |u Division of Gastrointestinal Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi Sunto-gun, 411-8777, Shizuoka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hamauchi |D Satoshi |u Division of Gastrointestinal Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi Sunto-gun, 411-8777, Shizuoka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tsushima |D Takahiro |u Division of Gastrointestinal Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi Sunto-gun, 411-8777, Shizuoka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Todaka |D Akiko |u Division of Gastrointestinal Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi Sunto-gun, 411-8777, Shizuoka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Machida |D Nozomu |u Division of Gastrointestinal Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi Sunto-gun, 411-8777, Shizuoka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Haraguchi |D Yutaka |u Division of Gastrointestinal Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi Sunto-gun, 411-8777, Shizuoka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ogawa |D Hirofumi |u Division of Radiation Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi Sunto-gun, 411-8777, Shizuoka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nishimura |D Tetsuo |u Division of Radiation Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi Sunto-gun, 411-8777, Shizuoka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nakagawa |D Masahiro |u Division of Plastic and Reconstructive Surgery, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi Sunto-gun, 411-8777, Shizuoka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Fuke |D Tomohito |u Division of Head and Neck Surgery, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi Sunto-gun, 411-8777, Shizuoka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Iida |D Yoshiyuki |u Division of Head and Neck Surgery, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi Sunto-gun, 411-8777, Shizuoka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kamijo |D Tomoyuki |u Division of Head and Neck Surgery, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi Sunto-gun, 411-8777, Shizuoka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Onitsuka |D Tetsuro |u Division of Head and Neck Surgery, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi Sunto-gun, 411-8777, Shizuoka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Boku |D Narikazu |u Division of Clinical Oncology, St. Marianna University School of Medicine, 2-16-1 Sugao Miyamae-ku, 216-8511, Kawasaki, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yasui |D Hirofumi |u Division of Gastrointestinal Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi Sunto-gun, 411-8777, Shizuoka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yokota |D Tomoya |u Division of Gastrointestinal Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi Sunto-gun, 411-8777, Shizuoka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t International Journal of Clinical Oncology |d Springer Japan |g 20/3(2015-06-01), 455-462 |x 1341-9625 |q 20:3<455 |1 2015 |2 20 |o 10147 | ||