Feasibility and efficacy of induction docetaxel, cisplatin, and 5-fluorouracil chemotherapy combined with concurrent weekly cisplatin chemoradiotherapy for locally advanced head and neck squamous cell carcinoma
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| 024 | 7 | 0 | |a 10.1007/s10147-014-0726-y |2 doi |
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| 245 | 0 | 0 | |a Feasibility and efficacy of induction docetaxel, cisplatin, and 5-fluorouracil chemotherapy combined with concurrent weekly cisplatin chemoradiotherapy for locally advanced head and neck squamous cell carcinoma |h [Elektronische Daten] |c [Takatsugu Mizumachi, Akihiro Homma, Tomohiko Kakizaki, Tomohiro Sakashita, Satoshi Kano, Hiromitsu Hatakeyama, Kazuhiko Tsuchiya, Koichi Yasuda, Rikiya Onimaru, Hiroki Shirato, Jun Taguchi, Yasushi Shimizu, Ichiro Kinoshita, Hirotoshi Akita, Satoshi Fukuda] |
| 520 | 3 | |a Abstract : Background: The aim of this study was to evaluate the feasibility of induction docetaxel, cisplatin, and 5-fluorouracil chemotherapy followed by concurrent weekly cisplatin chemoradiotherapy for patients with locally advanced head and neck squamous cell carcinoma (HNSCC). Methods: Between 2010 and 2013, 30 patients with Stage IV HNSCC were treated in Hokkaido University Hospital with three cycles of induction chemotherapy (docetaxel 75mg/m2 and cisplatin 75mg/m2, day 1; and 5-fluorouracil 750mg/m2/day 120h continuous infusion, every 3weeks) followed by concurrent weekly cisplatin (40mg/m2, on weeks 1, 2, 3, 5, 6 and 7) chemoradiotherapy. Results: Three courses of induction chemotherapy were performed in 25 patients (83%) with grade 3-4 toxicities during induction chemotherapy observed in 22 patients (73%). The major toxicities were hematologic, with 22 cases (73%) showing grade 3-4 neutropenia. Radiotherapy was completed (70Gy) in 29 patients (97%), while a total of 19 patients (63%) completed five (13 patients) or six (6 patients) courses of chemotherapy. During concurrent chemoradiotherapy, no grade 4 hematological toxicities were observed. Grade 4 dermatitis was observed in one patient, and grade 3 mucositis was observed in 12 patients. There were no treatment-related deaths during the induction chemotherapy or concurrent chemoradiotherapy. The 1- and 2-year progression-free survival rates and the 1- and 2-year overall survival rates were 86%, 72%, and 89%, 81%, respectively. Conclusion: Sequential therapy composed of induction chemotherapy followed by concurrent weekly cisplatin chemoradiotherapy is feasible, showing encouraging results in patients with locally advanced HNSCC. Concurrent weekly cisplatin chemoradiotherapy following induction chemotherapy appears to be a suitable alternative to three-weekly high-dose cisplatin therapy. | |
| 540 | |a Japan Society of Clinical Oncology, 2014 | ||
| 690 | 7 | |a Head and neck cancer |2 nationallicence | |
| 690 | 7 | |a Induction chemotherapy |2 nationallicence | |
| 690 | 7 | |a Chemoradiotherapy |2 nationallicence | |
| 700 | 1 | |a Mizumachi |D Takatsugu |u Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Homma |D Akihiro |u Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Kakizaki |D Tomohiko |u Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Sakashita |D Tomohiro |u Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Kano |D Satoshi |u Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Hatakeyama |D Hiromitsu |u Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Tsuchiya |D Kazuhiko |u Department of Radiation Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Yasuda |D Koichi |u Department of Radiation Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Onimaru |D Rikiya |u Department of Radiation Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Shirato |D Hiroki |u Department of Radiation Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Taguchi |D Jun |u Department of Medical Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Shimizu |D Yasushi |u Department of Medical Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Kinoshita |D Ichiro |u Department of Medical Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Akita |D Hirotoshi |u Department of Medical Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Fukuda |D Satoshi |u Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan |4 aut | |
| 773 | 0 | |t International Journal of Clinical Oncology |d Springer Japan |g 20/3(2015-06-01), 431-437 |x 1341-9625 |q 20:3<431 |1 2015 |2 20 |o 10147 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10147-014-0726-y |q text/html |z Onlinezugriff via DOI |
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10147-014-0726-y |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Mizumachi |D Takatsugu |u Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Homma |D Akihiro |u Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kakizaki |D Tomohiko |u Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sakashita |D Tomohiro |u Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kano |D Satoshi |u Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hatakeyama |D Hiromitsu |u Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tsuchiya |D Kazuhiko |u Department of Radiation Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yasuda |D Koichi |u Department of Radiation Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Onimaru |D Rikiya |u Department of Radiation Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Shirato |D Hiroki |u Department of Radiation Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Taguchi |D Jun |u Department of Medical Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Shimizu |D Yasushi |u Department of Medical Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kinoshita |D Ichiro |u Department of Medical Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Akita |D Hirotoshi |u Department of Medical Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Fukuda |D Satoshi |u Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, 060-8638, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t International Journal of Clinical Oncology |d Springer Japan |g 20/3(2015-06-01), 431-437 |x 1341-9625 |q 20:3<431 |1 2015 |2 20 |o 10147 | ||