Clinical implications of a prostate-specific antigen bounce after radiation therapy for prostate cancer
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| 024 | 7 | 0 | |a 10.1007/s10147-014-0745-8 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10147-014-0745-8 | ||
| 245 | 0 | 0 | |a Clinical implications of a prostate-specific antigen bounce after radiation therapy for prostate cancer |h [Elektronische Daten] |c [Arash Naghavi, Tobin Strom, Kevin Nethers, Alex Cruz, Nicholas Figura, Kushagra Shrinath, Binglin Yue, Jongphil Kim, Matthew Biagioli, Daniel Fernandez, Randy Heysek, Richard Wilder] |
| 520 | 3 | |a Abstract : Background: The objectives are to determine predictors of a prostate-specific antigen (PSA) bounce, whether a PSA bounce after radiotherapy for prostate cancer is associated with biochemical disease-free survival (bDFS), and the time course to a PSA bounce versus a biochemical failure post-irradiation. Methods: Between July 2000 and December 2012, 691 prostate cancer patients without regional or distant metastases were treated with external beam radiation therapy and/or brachytherapy, and had at least 12months of follow-up. A PSA bounce was defined as a temporary PSA increase of ≥0.4ng/mL. bDFS was defined according to the nadir+2 definition. Results: The median follow-up was 42months. The median time to first PSA bounce was 17months (95% confidence interval 15-18months). In contrast, the median time to biochemical failure was 41months (95% confidence interval 28-53months). Two hundred and twenty-six of 691 (33%) patients had at least one PSA bounce with a median magnitude of 1.0ng/mL (range 0.4-17.0). A Gleason score of 6 (p<0.0001) predicted a PSA bounce on multivariate analysis. Patients with a PSA bounce experienced improved bDFS on multivariate analysis (p=0.002). Conclusions: Patients with a Gleason score of 6 were more likely to experience a PSA bounce which was associated with improved bDFS. A PSA bounce occurred sooner after radiotherapy than a biochemical failure. The authors recommend against performing prostate biopsies within 24-30months of radiotherapy since an elevated PSA may simply represent a benign PSA bounce. | |
| 540 | |a Japan Society of Clinical Oncology, 2014 | ||
| 690 | 7 | |a Prostatic neoplasms |2 nationallicence | |
| 690 | 7 | |a Radiotherapy |2 nationallicence | |
| 690 | 7 | |a Prostate-specific antigen |2 nationallicence | |
| 700 | 1 | |a Naghavi |D Arash |u Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA |4 aut | |
| 700 | 1 | |a Strom |D Tobin |u Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA |4 aut | |
| 700 | 1 | |a Nethers |D Kevin |u Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA |4 aut | |
| 700 | 1 | |a Cruz |D Alex |u Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA |4 aut | |
| 700 | 1 | |a Figura |D Nicholas |u Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA |4 aut | |
| 700 | 1 | |a Shrinath |D Kushagra |u Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA |4 aut | |
| 700 | 1 | |a Yue |D Binglin |u Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA |4 aut | |
| 700 | 1 | |a Kim |D Jongphil |u Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA |4 aut | |
| 700 | 1 | |a Biagioli |D Matthew |u Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA |4 aut | |
| 700 | 1 | |a Fernandez |D Daniel |u Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA |4 aut | |
| 700 | 1 | |a Heysek |D Randy |u Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA |4 aut | |
| 700 | 1 | |a Wilder |D Richard |u Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA |4 aut | |
| 773 | 0 | |t International Journal of Clinical Oncology |d Springer Japan |g 20/3(2015-06-01), 598-604 |x 1341-9625 |q 20:3<598 |1 2015 |2 20 |o 10147 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10147-014-0745-8 |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10147-014-0745-8 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Naghavi |D Arash |u Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Strom |D Tobin |u Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nethers |D Kevin |u Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Cruz |D Alex |u Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Figura |D Nicholas |u Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Shrinath |D Kushagra |u Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yue |D Binglin |u Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kim |D Jongphil |u Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Biagioli |D Matthew |u Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Fernandez |D Daniel |u Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Heysek |D Randy |u Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Wilder |D Richard |u Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t International Journal of Clinical Oncology |d Springer Japan |g 20/3(2015-06-01), 598-604 |x 1341-9625 |q 20:3<598 |1 2015 |2 20 |o 10147 | ||