caa a22 4500 605491097 CHVBK 20210128100508.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s10147-014-0745-8 doi (NATIONALLICENCE)springer-10.1007/s10147-014-0745-8 Clinical implications of a prostate-specific antigen bounce after radiation therapy for prostate cancer [Elektronische Daten] [Arash Naghavi, Tobin Strom, Kevin Nethers, Alex Cruz, Nicholas Figura, Kushagra Shrinath, Binglin Yue, Jongphil Kim, Matthew Biagioli, Daniel Fernandez, Randy Heysek, Richard Wilder] Abstract : Background: The objectives are to determine predictors of a prostate-specific antigen (PSA) bounce, whether a PSA bounce after radiotherapy for prostate cancer is associated with biochemical disease-free survival (bDFS), and the time course to a PSA bounce versus a biochemical failure post-irradiation. Methods: Between July 2000 and December 2012, 691 prostate cancer patients without regional or distant metastases were treated with external beam radiation therapy and/or brachytherapy, and had at least 12months of follow-up. A PSA bounce was defined as a temporary PSA increase of ≥0.4ng/mL. bDFS was defined according to the nadir+2 definition. Results: The median follow-up was 42months. The median time to first PSA bounce was 17months (95% confidence interval 15-18months). In contrast, the median time to biochemical failure was 41months (95% confidence interval 28-53months). Two hundred and twenty-six of 691 (33%) patients had at least one PSA bounce with a median magnitude of 1.0ng/mL (range 0.4-17.0). A Gleason score of 6 (p<0.0001) predicted a PSA bounce on multivariate analysis. Patients with a PSA bounce experienced improved bDFS on multivariate analysis (p=0.002). Conclusions: Patients with a Gleason score of 6 were more likely to experience a PSA bounce which was associated with improved bDFS. A PSA bounce occurred sooner after radiotherapy than a biochemical failure. The authors recommend against performing prostate biopsies within 24-30months of radiotherapy since an elevated PSA may simply represent a benign PSA bounce. Japan Society of Clinical Oncology, 2014 Prostatic neoplasms nationallicence Radiotherapy nationallicence Prostate-specific antigen nationallicence Naghavi Arash Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA aut Strom Tobin Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA aut Nethers Kevin Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA aut Cruz Alex Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA aut Figura Nicholas Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA aut Shrinath Kushagra Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA aut Yue Binglin Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA aut Kim Jongphil Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA aut Biagioli Matthew Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA aut Fernandez Daniel Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA aut Heysek Randy Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA aut Wilder Richard Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA aut International Journal of Clinical Oncology Springer Japan 20/3(2015-06-01), 598-604 1341-9625 20:3<598 2015 20 10147 https://doi.org/10.1007/s10147-014-0745-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10147-014-0745-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Naghavi Arash Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA aut NATIONALLICENCE 700 1- Strom Tobin Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA aut NATIONALLICENCE 700 1- Nethers Kevin Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA aut NATIONALLICENCE 700 1- Cruz Alex Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA aut NATIONALLICENCE 700 1- Figura Nicholas Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA aut NATIONALLICENCE 700 1- Shrinath Kushagra Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA aut NATIONALLICENCE 700 1- Yue Binglin Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA aut NATIONALLICENCE 700 1- Kim Jongphil Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA aut NATIONALLICENCE 700 1- Biagioli Matthew Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA aut NATIONALLICENCE 700 1- Fernandez Daniel Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA aut NATIONALLICENCE 700 1- Heysek Randy Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA aut NATIONALLICENCE 700 1- Wilder Richard Department of Radiation Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, 33612, Tampa, FL, USA aut NATIONALLICENCE 773 0- International Journal of Clinical Oncology Springer Japan 20/3(2015-06-01), 598-604 1341-9625 20:3<598 2015 20 10147