Effect of skip lymphovascular invasion on hepatic metastasis in colorectal carcinomas
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| 024 | 7 | 0 | |a 10.1007/s10147-014-0778-z |2 doi |
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| 245 | 0 | 0 | |a Effect of skip lymphovascular invasion on hepatic metastasis in colorectal carcinomas |h [Elektronische Daten] |c [Yosuke Okamoto, Hiroyuki Mitomi, Kazuhito Ichikawa, Shigeki Tomita, Takahiro Fujimori, Yoshinori Igarashi] |
| 520 | 3 | |a Background: "Skip” lymphovascular invasion presenting as discontinuous foci of tumor cells within the colon wall is now excluded from consideration when determining T stage in the TNM classification. The purpose of this study was to assess the clinicopathological characteristics of colorectal cancer (CRC) patients with such skip lymphovascular invasion. Methods: First, a retrospective questionnaire survey of the incidence of skip lymphovascular invasion was performed for a total of 1,868 patients with CRCs at ten institutions. Next, we comparatively assessed clinicopathological data for 896 CRC patients with or without skip lymphovascular invasion. Results: The incidence of skip lymphovascular invasion was 1.1% (20 out of 1,868). Most of the affected cases were rectal, pT2, and node negative, with moderately differentiated histology. Skip lymphovascular invasion was present in the muscularis propria and subserosa, with the tumors directly invading submucosa (pT1) or muscularis propria (pT2). Hepatic metastasis was greater in CRC with skip lymphovascular invasion (25%) than in pT1/2 CRC (0%; P<0.001) or pT3 CRC without such invasion (13.8%; P=0.185). Conclusions: Our study suggests that skip lymphovascular invasion is associated with hepatic metastasis in CRC cases. Thus, definition of a T category including such invasion would be useful for clinical practice. | |
| 540 | |a Japan Society of Clinical Oncology, 2014 | ||
| 690 | 7 | |a Skip metastasis |2 nationallicence | |
| 690 | 7 | |a Lymphovascular invasion |2 nationallicence | |
| 690 | 7 | |a Colon carcinoma |2 nationallicence | |
| 690 | 7 | |a Liver metastasis |2 nationallicence | |
| 700 | 1 | |a Okamoto |D Yosuke |u Division of Gastroenterology and Hepatology, Department of Internal Medicine, Toho University Omori Medical Center, 6-11-1 Omorinishi, Ota-ku, 143-8541, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Mitomi |D Hiroyuki |u Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu, 321-0293, Shimotsuga, Tochigi, Japan |4 aut | |
| 700 | 1 | |a Ichikawa |D Kazuhito |u Regional Medical Support Center, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Fukushima, Japan |4 aut | |
| 700 | 1 | |a Tomita |D Shigeki |u Department of Pathology, Juntendo University Urayasu Hospital, 2-1-1 Tomioka, 279-0021, Urayasu, Chiba, Japan |4 aut | |
| 700 | 1 | |a Fujimori |D Takahiro |u Department of Pathology, Shinko Hospital, 1-4-47 Wakihama-cho, Chuo-ku, 651-0072, Kobe, Hyogo, Japan |4 aut | |
| 700 | 1 | |a Igarashi |D Yoshinori |u Division of Gastroenterology and Hepatology, Department of Internal Medicine, Toho University Omori Medical Center, 6-11-1 Omorinishi, Ota-ku, 143-8541, Tokyo, Japan |4 aut | |
| 773 | 0 | |t International Journal of Clinical Oncology |d Springer Japan |g 20/4(2015-08-01), 761-766 |x 1341-9625 |q 20:4<761 |1 2015 |2 20 |o 10147 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10147-014-0778-z |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10147-014-0778-z |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Okamoto |D Yosuke |u Division of Gastroenterology and Hepatology, Department of Internal Medicine, Toho University Omori Medical Center, 6-11-1 Omorinishi, Ota-ku, 143-8541, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Mitomi |D Hiroyuki |u Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu, 321-0293, Shimotsuga, Tochigi, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ichikawa |D Kazuhito |u Regional Medical Support Center, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Fukushima, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tomita |D Shigeki |u Department of Pathology, Juntendo University Urayasu Hospital, 2-1-1 Tomioka, 279-0021, Urayasu, Chiba, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Fujimori |D Takahiro |u Department of Pathology, Shinko Hospital, 1-4-47 Wakihama-cho, Chuo-ku, 651-0072, Kobe, Hyogo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Igarashi |D Yoshinori |u Division of Gastroenterology and Hepatology, Department of Internal Medicine, Toho University Omori Medical Center, 6-11-1 Omorinishi, Ota-ku, 143-8541, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t International Journal of Clinical Oncology |d Springer Japan |g 20/4(2015-08-01), 761-766 |x 1341-9625 |q 20:4<761 |1 2015 |2 20 |o 10147 | ||