caa a22 4500 605491100 CHVBK 20210128100508.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s10147-014-0778-z doi (NATIONALLICENCE)springer-10.1007/s10147-014-0778-z Effect of skip lymphovascular invasion on hepatic metastasis in colorectal carcinomas [Elektronische Daten] [Yosuke Okamoto, Hiroyuki Mitomi, Kazuhito Ichikawa, Shigeki Tomita, Takahiro Fujimori, Yoshinori Igarashi] Background: "Skip” lymphovascular invasion presenting as discontinuous foci of tumor cells within the colon wall is now excluded from consideration when determining T stage in the TNM classification. The purpose of this study was to assess the clinicopathological characteristics of colorectal cancer (CRC) patients with such skip lymphovascular invasion. Methods: First, a retrospective questionnaire survey of the incidence of skip lymphovascular invasion was performed for a total of 1,868 patients with CRCs at ten institutions. Next, we comparatively assessed clinicopathological data for 896 CRC patients with or without skip lymphovascular invasion. Results: The incidence of skip lymphovascular invasion was 1.1% (20 out of 1,868). Most of the affected cases were rectal, pT2, and node negative, with moderately differentiated histology. Skip lymphovascular invasion was present in the muscularis propria and subserosa, with the tumors directly invading submucosa (pT1) or muscularis propria (pT2). Hepatic metastasis was greater in CRC with skip lymphovascular invasion (25%) than in pT1/2 CRC (0%; P<0.001) or pT3 CRC without such invasion (13.8%; P=0.185). Conclusions: Our study suggests that skip lymphovascular invasion is associated with hepatic metastasis in CRC cases. Thus, definition of a T category including such invasion would be useful for clinical practice. Japan Society of Clinical Oncology, 2014 Skip metastasis nationallicence Lymphovascular invasion nationallicence Colon carcinoma nationallicence Liver metastasis nationallicence Okamoto Yosuke Division of Gastroenterology and Hepatology, Department of Internal Medicine, Toho University Omori Medical Center, 6-11-1 Omorinishi, Ota-ku, 143-8541, Tokyo, Japan aut Mitomi Hiroyuki Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu, 321-0293, Shimotsuga, Tochigi, Japan aut Ichikawa Kazuhito Regional Medical Support Center, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Fukushima, Japan aut Tomita Shigeki Department of Pathology, Juntendo University Urayasu Hospital, 2-1-1 Tomioka, 279-0021, Urayasu, Chiba, Japan aut Fujimori Takahiro Department of Pathology, Shinko Hospital, 1-4-47 Wakihama-cho, Chuo-ku, 651-0072, Kobe, Hyogo, Japan aut Igarashi Yoshinori Division of Gastroenterology and Hepatology, Department of Internal Medicine, Toho University Omori Medical Center, 6-11-1 Omorinishi, Ota-ku, 143-8541, Tokyo, Japan aut International Journal of Clinical Oncology Springer Japan 20/4(2015-08-01), 761-766 1341-9625 20:4<761 2015 20 10147 https://doi.org/10.1007/s10147-014-0778-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10147-014-0778-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Okamoto Yosuke Division of Gastroenterology and Hepatology, Department of Internal Medicine, Toho University Omori Medical Center, 6-11-1 Omorinishi, Ota-ku, 143-8541, Tokyo, Japan aut NATIONALLICENCE 700 1- Mitomi Hiroyuki Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu, 321-0293, Shimotsuga, Tochigi, Japan aut NATIONALLICENCE 700 1- Ichikawa Kazuhito Regional Medical Support Center, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Fukushima, Japan aut NATIONALLICENCE 700 1- Tomita Shigeki Department of Pathology, Juntendo University Urayasu Hospital, 2-1-1 Tomioka, 279-0021, Urayasu, Chiba, Japan aut NATIONALLICENCE 700 1- Fujimori Takahiro Department of Pathology, Shinko Hospital, 1-4-47 Wakihama-cho, Chuo-ku, 651-0072, Kobe, Hyogo, Japan aut NATIONALLICENCE 700 1- Igarashi Yoshinori Division of Gastroenterology and Hepatology, Department of Internal Medicine, Toho University Omori Medical Center, 6-11-1 Omorinishi, Ota-ku, 143-8541, Tokyo, Japan aut NATIONALLICENCE 773 0- International Journal of Clinical Oncology Springer Japan 20/4(2015-08-01), 761-766 1341-9625 20:4<761 2015 20 10147