caa a22 4500 605491119 CHVBK 20210128100508.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s10147-014-0771-6 doi (NATIONALLICENCE)springer-10.1007/s10147-014-0771-6 Primary tracheal adenoid cystic carcinoma: adjuvant treatment outcome [Elektronische Daten] [Furong Chen, Meijuan Huang, Yong Xu, Tao Li, Ke Xie, Ling Zhang, Deyun Cheng, Lunxu Liu, Guowei Che, Mei Hou, Jin Wang, Zhaohui Luo, You Lu] Background: Adenoid cystic carcinoma (ACC) is the second most common tracheal tumor, but its optimal treatment strategy is still controversial. Methods: To further elucidate the impact of treatment on disease-free survival (DFS) and overall survival (OS), we retrospectively investigated different treatment modalities and outcomes of 56 patients with primary ACC of the trachea treated at four hospitals in Sichuan Province of China from 1995 to 2012. Results: 52 patients were included in the analysis. 4 patients with unresectable tumors were treated primarily with radiotherapy (RT) alone. 11 of 48 patients who received surgery as primary therapy obtained complete resection without adjuvant therapy. 24 of 37 patients who had incomplete resection (R1, R2) received postoperative RT while 13 patients were treated without postoperative RT. Postoperative chemotherapy (CT) was used in 12 patients with postoperative RT. No significant difference was shown in DFS (p=0.683) and OS (p=0.829) between patients with complete resection and those with incomplete resection. Postoperative RT for patients with incomplete resection was associated with improved DFS (92 vs. 62months, p=0.027) and OS (125 vs. 78months, p=0.004). Postoperative chemotherapy (CT) following RT did not have a significant impact on DFS (p=0.390) or OS (p=0.646) in patients with positive margin. Conclusions: These observations suggest that postoperative RT should probably be recommended for patients with incomplete resection. Postoperative CT following RT in patients with incomplete resection did not seem to produce an additional survival benefit. Japan Society of Clinical Oncology, 2014 Adenoid cystic carcinoma nationallicence Trachea nationallicence Surgery nationallicence Radiotherapy nationallicence Chemotherapy nationallicence Chen Furong Department of Thoracic Oncology, Cancer Center, West China Hospital, Medical School, Sichuan University, No. 37 Guo Xue Xiang, 610041, Chengdu, Sichuan, China aut Huang Meijuan Department of Thoracic Oncology, Cancer Center, West China Hospital, Medical School, Sichuan University, No. 37 Guo Xue Xiang, 610041, Chengdu, Sichuan, China aut Xu Yong Department of Thoracic Oncology, Cancer Center, West China Hospital, Medical School, Sichuan University, No. 37 Guo Xue Xiang, 610041, Chengdu, Sichuan, China aut Li Tao Department of Radiotherapy, Sichuan Province Cancer Hospital, Chengdu, China aut Xie Ke Department of Oncology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, China aut Zhang Ling Department of Oncology, General Hospital of Chengdu Military Region of PLA (Chinese People's Liberation Army), Chengdu, China aut Cheng Deyun Department of Respiration, West China Hospital, Medical School, Sichuan University, Chengdu, China aut Liu Lunxu Department of Thoracic Surgery, West China Hospital, Medical School, Sichuan University, Chengdu, China aut Che Guowei Department of Thoracic Surgery, West China Hospital, Medical School, Sichuan University, Chengdu, China aut Hou Mei Department of Thoracic Oncology, Cancer Center, West China Hospital, Medical School, Sichuan University, No. 37 Guo Xue Xiang, 610041, Chengdu, Sichuan, China aut Wang Jin Department of Thoracic Oncology, Cancer Center, West China Hospital, Medical School, Sichuan University, No. 37 Guo Xue Xiang, 610041, Chengdu, Sichuan, China aut Luo Zhaohui Department of Pediatrics, Xuanhan County People's Hospital, Dazhou, China aut Lu You Department of Thoracic Oncology, Cancer Center, West China Hospital, Medical School, Sichuan University, No. 37 Guo Xue Xiang, 610041, Chengdu, Sichuan, China aut International Journal of Clinical Oncology Springer Japan 20/4(2015-08-01), 686-692 1341-9625 20:4<686 2015 20 10147 https://doi.org/10.1007/s10147-014-0771-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10147-014-0771-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chen Furong Department of Thoracic Oncology, Cancer Center, West China Hospital, Medical School, Sichuan University, No. 37 Guo Xue Xiang, 610041, Chengdu, Sichuan, China aut NATIONALLICENCE 700 1- Huang Meijuan Department of Thoracic Oncology, Cancer Center, West China Hospital, Medical School, Sichuan University, No. 37 Guo Xue Xiang, 610041, Chengdu, Sichuan, China aut NATIONALLICENCE 700 1- Xu Yong Department of Thoracic Oncology, Cancer Center, West China Hospital, Medical School, Sichuan University, No. 37 Guo Xue Xiang, 610041, Chengdu, Sichuan, China aut NATIONALLICENCE 700 1- Li Tao Department of Radiotherapy, Sichuan Province Cancer Hospital, Chengdu, China aut NATIONALLICENCE 700 1- Xie Ke Department of Oncology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, China aut NATIONALLICENCE 700 1- Zhang Ling Department of Oncology, General Hospital of Chengdu Military Region of PLA (Chinese People's Liberation Army), Chengdu, China aut NATIONALLICENCE 700 1- Cheng Deyun Department of Respiration, West China Hospital, Medical School, Sichuan University, Chengdu, China aut NATIONALLICENCE 700 1- Liu Lunxu Department of Thoracic Surgery, West China Hospital, Medical School, Sichuan University, Chengdu, China aut NATIONALLICENCE 700 1- Che Guowei Department of Thoracic Surgery, West China Hospital, Medical School, Sichuan University, Chengdu, China aut NATIONALLICENCE 700 1- Hou Mei Department of Thoracic Oncology, Cancer Center, West China Hospital, Medical School, Sichuan University, No. 37 Guo Xue Xiang, 610041, Chengdu, Sichuan, China aut NATIONALLICENCE 700 1- Wang Jin Department of Thoracic Oncology, Cancer Center, West China Hospital, Medical School, Sichuan University, No. 37 Guo Xue Xiang, 610041, Chengdu, Sichuan, China aut NATIONALLICENCE 700 1- Luo Zhaohui Department of Pediatrics, Xuanhan County People's Hospital, Dazhou, China aut NATIONALLICENCE 700 1- Lu You Department of Thoracic Oncology, Cancer Center, West China Hospital, Medical School, Sichuan University, No. 37 Guo Xue Xiang, 610041, Chengdu, Sichuan, China aut NATIONALLICENCE 773 0- International Journal of Clinical Oncology Springer Japan 20/4(2015-08-01), 686-692 1341-9625 20:4<686 2015 20 10147