Outcomes of abdominal radical trachelectomy: results of a multicenter prospective cohort study in a Tohoku Gynecologic Cancer Unit
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| 024 | 7 | 0 | |a 10.1007/s10147-014-0763-6 |2 doi |
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| 245 | 0 | 0 | |a Outcomes of abdominal radical trachelectomy: results of a multicenter prospective cohort study in a Tohoku Gynecologic Cancer Unit |h [Elektronische Daten] |c [Hideki Tokunaga, Yoh Watanabe, Hitoshi Niikura, Satoru Nagase, Masafumi Toyoshima, Reiji Shiro, Yoshihito Yokoyama, Hideki Mizunuma, Tsuyoshi Ohta, Hiroshi Nishiyama, Takafumi Watanabe, Naoto Sato, Toru Sugiyama, Tadao Takano, Fumiaki Takahashi, Nobuo Yaegashi] |
| 520 | 3 | |a Background: This study aimed to evaluate surgical, pregnancy, and prognostic outcomes of radical abdominal trachelectomy (RAT) for Japanese patients with early-stage cervical cancer. Methods: This was a multicenter prospective cohort study conducted in member facilities of Tohoku Gynecologic Cancer Unit. Patients with FIGO 1A-1B1 squamous cell carcinoma were included. Results: A total of 42 patients were registered in this study, and all patients underwent planned RAT. The median stromal invasion and median horizontal spread of resected specimens were 4.6 (range 1.0-10.0) and 12.4mm (range 3.0-28.0), respectively. The median surgical time and median blood loss were 304min (range 233-611) and 848mL (range 250-3984), respectively. Five patients (11.9%) received blood transfusion. Five of 18 (27.8%) patients who attempted to conceive achieved pregnancy, and 3 patients had healthy babies. However, all pregnancies required assisted reproductive technology with in-vitro fertilization and embryo transfer. Four patients (9.5%) received postoperative adjuvant therapy, and 3 patients (7.1%) developed disease recurrence. Conclusions: RAT may be safely performed for Japanese patients with FIGO 1A-1B1 squamous cell carcinoma of the cervix, even in educational medical facilities. However, less-invasive surgery should be considered more often to improve pregnancy outcomes. | |
| 540 | |a Japan Society of Clinical Oncology, 2014 | ||
| 690 | 7 | |a Abdominal trachelectomy |2 nationallicence | |
| 690 | 7 | |a Fertility-sparing surgery |2 nationallicence | |
| 690 | 7 | |a Cervical cancer |2 nationallicence | |
| 690 | 7 | |a Prospective cohort study |2 nationallicence | |
| 690 | 7 | |a Outcome |2 nationallicence | |
| 700 | 1 | |a Tokunaga |D Hideki |u Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan |4 aut | |
| 700 | 1 | |a Watanabe |D Yoh |u Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan |4 aut | |
| 700 | 1 | |a Niikura |D Hitoshi |u Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan |4 aut | |
| 700 | 1 | |a Nagase |D Satoru |u Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan |4 aut | |
| 700 | 1 | |a Toyoshima |D Masafumi |u Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan |4 aut | |
| 700 | 1 | |a Shiro |D Reiji |u Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan |4 aut | |
| 700 | 1 | |a Yokoyama |D Yoshihito |u Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan |4 aut | |
| 700 | 1 | |a Mizunuma |D Hideki |u Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan |4 aut | |
| 700 | 1 | |a Ohta |D Tsuyoshi |u Department of Obstetrics and Gynecology, Yamagata University Faculty of Medicine, Yamagata, Japan |4 aut | |
| 700 | 1 | |a Nishiyama |D Hiroshi |u Department of Obstetrics and Gynecology, Fukushima Medical University, Fukushima, Japan |4 aut | |
| 700 | 1 | |a Watanabe |D Takafumi |u Department of Obstetrics and Gynecology, Fukushima Medical University, Fukushima, Japan |4 aut | |
| 700 | 1 | |a Sato |D Naoto |u Department of Obstetrics and Gynecology, Akita University Graduate School of Medicine, Akita, Japan |4 aut | |
| 700 | 1 | |a Sugiyama |D Toru |u Department of Obstetrics and Gynecology, Iwate Medical University, Morioka, Japan |4 aut | |
| 700 | 1 | |a Takano |D Tadao |u Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan |4 aut | |
| 700 | 1 | |a Takahashi |D Fumiaki |u Department of Clinical Research Network, Clinical Research, Innovation and Education Center, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Miyagi, Japan |4 aut | |
| 700 | 1 | |a Yaegashi |D Nobuo |u Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan |4 aut | |
| 773 | 0 | |t International Journal of Clinical Oncology |d Springer Japan |g 20/4(2015-08-01), 776-780 |x 1341-9625 |q 20:4<776 |1 2015 |2 20 |o 10147 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10147-014-0763-6 |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10147-014-0763-6 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tokunaga |D Hideki |u Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Watanabe |D Yoh |u Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Niikura |D Hitoshi |u Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nagase |D Satoru |u Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Toyoshima |D Masafumi |u Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Shiro |D Reiji |u Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yokoyama |D Yoshihito |u Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Mizunuma |D Hideki |u Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ohta |D Tsuyoshi |u Department of Obstetrics and Gynecology, Yamagata University Faculty of Medicine, Yamagata, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nishiyama |D Hiroshi |u Department of Obstetrics and Gynecology, Fukushima Medical University, Fukushima, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Watanabe |D Takafumi |u Department of Obstetrics and Gynecology, Fukushima Medical University, Fukushima, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sato |D Naoto |u Department of Obstetrics and Gynecology, Akita University Graduate School of Medicine, Akita, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sugiyama |D Toru |u Department of Obstetrics and Gynecology, Iwate Medical University, Morioka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Takano |D Tadao |u Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Takahashi |D Fumiaki |u Department of Clinical Research Network, Clinical Research, Innovation and Education Center, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Miyagi, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yaegashi |D Nobuo |u Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t International Journal of Clinical Oncology |d Springer Japan |g 20/4(2015-08-01), 776-780 |x 1341-9625 |q 20:4<776 |1 2015 |2 20 |o 10147 | ||