caa a22 4500 605491135 CHVBK 20210128100508.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s10147-014-0763-6 doi (NATIONALLICENCE)springer-10.1007/s10147-014-0763-6 Outcomes of abdominal radical trachelectomy: results of a multicenter prospective cohort study in a Tohoku Gynecologic Cancer Unit [Elektronische Daten] [Hideki Tokunaga, Yoh Watanabe, Hitoshi Niikura, Satoru Nagase, Masafumi Toyoshima, Reiji Shiro, Yoshihito Yokoyama, Hideki Mizunuma, Tsuyoshi Ohta, Hiroshi Nishiyama, Takafumi Watanabe, Naoto Sato, Toru Sugiyama, Tadao Takano, Fumiaki Takahashi, Nobuo Yaegashi] Background: This study aimed to evaluate surgical, pregnancy, and prognostic outcomes of radical abdominal trachelectomy (RAT) for Japanese patients with early-stage cervical cancer. Methods: This was a multicenter prospective cohort study conducted in member facilities of Tohoku Gynecologic Cancer Unit. Patients with FIGO 1A-1B1 squamous cell carcinoma were included. Results: A total of 42 patients were registered in this study, and all patients underwent planned RAT. The median stromal invasion and median horizontal spread of resected specimens were 4.6 (range 1.0-10.0) and 12.4mm (range 3.0-28.0), respectively. The median surgical time and median blood loss were 304min (range 233-611) and 848mL (range 250-3984), respectively. Five patients (11.9%) received blood transfusion. Five of 18 (27.8%) patients who attempted to conceive achieved pregnancy, and 3 patients had healthy babies. However, all pregnancies required assisted reproductive technology with in-vitro fertilization and embryo transfer. Four patients (9.5%) received postoperative adjuvant therapy, and 3 patients (7.1%) developed disease recurrence. Conclusions: RAT may be safely performed for Japanese patients with FIGO 1A-1B1 squamous cell carcinoma of the cervix, even in educational medical facilities. However, less-invasive surgery should be considered more often to improve pregnancy outcomes. Japan Society of Clinical Oncology, 2014 Abdominal trachelectomy nationallicence Fertility-sparing surgery nationallicence Cervical cancer nationallicence Prospective cohort study nationallicence Outcome nationallicence Tokunaga Hideki Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan aut Watanabe Yoh Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan aut Niikura Hitoshi Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan aut Nagase Satoru Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan aut Toyoshima Masafumi Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan aut Shiro Reiji Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan aut Yokoyama Yoshihito Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan aut Mizunuma Hideki Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan aut Ohta Tsuyoshi Department of Obstetrics and Gynecology, Yamagata University Faculty of Medicine, Yamagata, Japan aut Nishiyama Hiroshi Department of Obstetrics and Gynecology, Fukushima Medical University, Fukushima, Japan aut Watanabe Takafumi Department of Obstetrics and Gynecology, Fukushima Medical University, Fukushima, Japan aut Sato Naoto Department of Obstetrics and Gynecology, Akita University Graduate School of Medicine, Akita, Japan aut Sugiyama Toru Department of Obstetrics and Gynecology, Iwate Medical University, Morioka, Japan aut Takano Tadao Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan aut Takahashi Fumiaki Department of Clinical Research Network, Clinical Research, Innovation and Education Center, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Miyagi, Japan aut Yaegashi Nobuo Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan aut International Journal of Clinical Oncology Springer Japan 20/4(2015-08-01), 776-780 1341-9625 20:4<776 2015 20 10147 https://doi.org/10.1007/s10147-014-0763-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10147-014-0763-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tokunaga Hideki Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan aut NATIONALLICENCE 700 1- Watanabe Yoh Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan aut NATIONALLICENCE 700 1- Niikura Hitoshi Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan aut NATIONALLICENCE 700 1- Nagase Satoru Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan aut NATIONALLICENCE 700 1- Toyoshima Masafumi Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan aut NATIONALLICENCE 700 1- Shiro Reiji Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan aut NATIONALLICENCE 700 1- Yokoyama Yoshihito Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan aut NATIONALLICENCE 700 1- Mizunuma Hideki Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan aut NATIONALLICENCE 700 1- Ohta Tsuyoshi Department of Obstetrics and Gynecology, Yamagata University Faculty of Medicine, Yamagata, Japan aut NATIONALLICENCE 700 1- Nishiyama Hiroshi Department of Obstetrics and Gynecology, Fukushima Medical University, Fukushima, Japan aut NATIONALLICENCE 700 1- Watanabe Takafumi Department of Obstetrics and Gynecology, Fukushima Medical University, Fukushima, Japan aut NATIONALLICENCE 700 1- Sato Naoto Department of Obstetrics and Gynecology, Akita University Graduate School of Medicine, Akita, Japan aut NATIONALLICENCE 700 1- Sugiyama Toru Department of Obstetrics and Gynecology, Iwate Medical University, Morioka, Japan aut NATIONALLICENCE 700 1- Takano Tadao Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan aut NATIONALLICENCE 700 1- Takahashi Fumiaki Department of Clinical Research Network, Clinical Research, Innovation and Education Center, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Miyagi, Japan aut NATIONALLICENCE 700 1- Yaegashi Nobuo Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan aut NATIONALLICENCE 773 0- International Journal of Clinical Oncology Springer Japan 20/4(2015-08-01), 776-780 1341-9625 20:4<776 2015 20 10147