Hepatic arterial infusion chemotherapy with fine-powder cisplatin and iodized-oil suspension in patients with intermediate-stage and advanced-stage (Barcelona Clinic Liver Cancer stage-B or stage-C) hepatocellular carcinoma: multicenter phase-II clinical study
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| 024 | 7 | 0 | |a 10.1007/s10147-014-0773-4 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10147-014-0773-4 | ||
| 245 | 0 | 0 | |a Hepatic arterial infusion chemotherapy with fine-powder cisplatin and iodized-oil suspension in patients with intermediate-stage and advanced-stage (Barcelona Clinic Liver Cancer stage-B or stage-C) hepatocellular carcinoma: multicenter phase-II clinical study |h [Elektronische Daten] |c [Haruyuki Takaki, Koichiro Yamakado, Masakatsu Tsurusaki, Taku Yasumoto, Yasutaka Baba, Yoshiaki Narimatsu, Masashi Shimohira, Masato Yamaguchi, Kunihiro Matsuo, Yoshitaka Inaba, Koji Mikami, Ryohei Watanabe, Norifumi Nishida, Hiroshi Anai, Hideaki Kakizawa, Shozo Hirota] |
| 520 | 3 | |a Purpose: This single-arm, multicenter, phase-II trial evaluated the efficacy and safety of hepatic arterial infusion chemotherapy (HAIC) using fine-powder cisplatin and iodized-oil suspension in patients with intermediate- and advanced-stage [Barcelona Clinic Liver Cancer (BCLC) stage-B and stage-C] hepatocellular carcinomas (HCCs). Methods: The Institutional Review Board approved this study and patients provided written informed consent. Thirty-five patients (24 men and 11 women, mean 74±6years [range 60-87years]) with BCLC stage-B (57%, 20/35) or stage-C (43%, 15/35) HCCs who were not candidates for other locoregional treatments were enrolled. HAIC was performed using a suspension of fine-powder cisplatin with a maximum dose of 65mg/m2 and iodized oil on demand. The primary endpoint was the response rate evaluated based on Response Evaluation Criteria in Solid Tumor (RECIST) and modified RECIST (mRECIST). Secondary endpoints were overall survival, progression-free survival, and safety. Results: The initial and best overall response rates at 4weeks and 3months, respectively, were 14 and 17% based on RECIST, and 57 and 23% based on mRECIST. The median overall and progression-free survival times were 18 and 4months, respectively. The most frequent grade-3 or grade-4 adverse events were elevation of serum alanine (23%) and aspartate aminotransferase (20%), and thrombocytopenia (17%). Conclusion: This HAIC provides promising therapeutic effects with acceptable safety to patients with intermediate-stage and advanced-stage HCCs. | |
| 540 | |a Japan Society of Clinical Oncology, 2014 | ||
| 690 | 7 | |a Hepatic arterial infusion chemotherapy |2 nationallicence | |
| 690 | 7 | |a Fine-powder cisplatin |2 nationallicence | |
| 690 | 7 | |a Iodized oil |2 nationallicence | |
| 690 | 7 | |a Hepatocellular carcinomas |2 nationallicence | |
| 700 | 1 | |a Takaki |D Haruyuki |u Department of Radiology, Mie University School of Medicine, Mie, Japan |4 aut | |
| 700 | 1 | |a Yamakado |D Koichiro |u Department of Radiology, Mie University School of Medicine, Mie, Japan |4 aut | |
| 700 | 1 | |a Tsurusaki |D Masakatsu |u Department of Radiology, Shimane University Faculty of Medicine, Izumo, Japan |4 aut | |
| 700 | 1 | |a Yasumoto |D Taku |u Department of Radiology, Toyonaka Municipal Hospital, Toyonaka, Japan |4 aut | |
| 700 | 1 | |a Baba |D Yasutaka |u Department of Radiology, Kagoshima University, Kagoshima, Japan |4 aut | |
| 700 | 1 | |a Narimatsu |D Yoshiaki |u Department of Radiology, Kawasaki Municipal Hospital, Kawasaki, Japan |4 aut | |
| 700 | 1 | |a Shimohira |D Masashi |u Department of Radiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan |4 aut | |
| 700 | 1 | |a Yamaguchi |D Masato |u Center for Endovascular Therapy, Kobe University Graduate School of Medicine, Kobe, Japan |4 aut | |
| 700 | 1 | |a Matsuo |D Kunihiro |u Department of Radiology, Narumi Hospital, Hirosaki, Japan |4 aut | |
| 700 | 1 | |a Inaba |D Yoshitaka |u Department of Diagnostic and Interventional Radiology, Aichi Cancer Center Hospital, Nagoya, Japan |4 aut | |
| 700 | 1 | |a Mikami |D Koji |u Department of Radiology, Suita Municipal Hospital, Suita, Japan |4 aut | |
| 700 | 1 | |a Watanabe |D Ryohei |u Department of Surgery, Matsuyama Shimin Hospital, Matsuyama, Japan |4 aut | |
| 700 | 1 | |a Nishida |D Norifumi |u Department of Radiology, Osaka City University Graduate School of Medicine, Osaka, Japan |4 aut | |
| 700 | 1 | |a Anai |D Hiroshi |u Department of Radiology, Nara Medical University, Kashiwara, Japan |4 aut | |
| 700 | 1 | |a Kakizawa |D Hideaki |u Department of Diagnostic Radiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan |4 aut | |
| 700 | 1 | |a Hirota |D Shozo |u Department of Radiology, Hyogo College of Medicine, Nishinomiya, Japan |4 aut | |
| 773 | 0 | |t International Journal of Clinical Oncology |d Springer Japan |g 20/4(2015-08-01), 745-754 |x 1341-9625 |q 20:4<745 |1 2015 |2 20 |o 10147 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10147-014-0773-4 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10147-014-0773-4 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Takaki |D Haruyuki |u Department of Radiology, Mie University School of Medicine, Mie, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yamakado |D Koichiro |u Department of Radiology, Mie University School of Medicine, Mie, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tsurusaki |D Masakatsu |u Department of Radiology, Shimane University Faculty of Medicine, Izumo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yasumoto |D Taku |u Department of Radiology, Toyonaka Municipal Hospital, Toyonaka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Baba |D Yasutaka |u Department of Radiology, Kagoshima University, Kagoshima, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Narimatsu |D Yoshiaki |u Department of Radiology, Kawasaki Municipal Hospital, Kawasaki, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Shimohira |D Masashi |u Department of Radiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yamaguchi |D Masato |u Center for Endovascular Therapy, Kobe University Graduate School of Medicine, Kobe, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Matsuo |D Kunihiro |u Department of Radiology, Narumi Hospital, Hirosaki, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Inaba |D Yoshitaka |u Department of Diagnostic and Interventional Radiology, Aichi Cancer Center Hospital, Nagoya, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Mikami |D Koji |u Department of Radiology, Suita Municipal Hospital, Suita, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Watanabe |D Ryohei |u Department of Surgery, Matsuyama Shimin Hospital, Matsuyama, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nishida |D Norifumi |u Department of Radiology, Osaka City University Graduate School of Medicine, Osaka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Anai |D Hiroshi |u Department of Radiology, Nara Medical University, Kashiwara, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kakizawa |D Hideaki |u Department of Diagnostic Radiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hirota |D Shozo |u Department of Radiology, Hyogo College of Medicine, Nishinomiya, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t International Journal of Clinical Oncology |d Springer Japan |g 20/4(2015-08-01), 745-754 |x 1341-9625 |q 20:4<745 |1 2015 |2 20 |o 10147 | ||