caa a22 4500 605491232 CHVBK 20210128100509.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s10147-014-0767-2 doi (NATIONALLICENCE)springer-10.1007/s10147-014-0767-2 Is mucinous adenocarcinoma of the endometrium a risk factor for lymph node involvement? A multicenter case-control study [Elektronische Daten] [Kemal Gungorduk, Aykut Ozdemir, Ibrahim Ertas, Ilker Selcuk, Ulas Solmaz, Emre Ozgu, Emre Mat, Mehmet Gokcu, Tuba Karadeniz, Serap Akbay, Muzaffer Sanci, Mehmet Meydanli, Duygu Ayaz, Tayfun Gungor] Purpose: The purpose of this multicenter case-control study was to compare the demographic and clinical characteristics of patients with mucinous adenocarcinoma of the endometrium (MAE) and endometrioid endometrial carcinoma (EEC). Methods: A retrospective review of two cancer registry databases in Turkey was conducted to identify patients diagnosed with MAE between January 1996 and December 2012. Each patient was matched with a control EEC patient by age and tumor grade. Cases and controls were compared in terms of known risk factors for lymph node metastasis, disease-free survival (DFS), and overall survival (OS). Results: The analysis included 112 patients with MAE and 112 with EEC. No significant difference in baseline characteristics was evident between the two groups. Lymphovascular space invasion, deep myometrial invasion, cervical involvement, and tumor diameter did not differ significantly between the mucinous and endometrioid cases. Multivariate analysis confirmed that only mucinous histology (OR 2.2, 95% CI 1.1-4.5; P=0.02) was an independent predictor of lymph node involvement. Although the median DFS and OS tended to be better in the endometrioid group, the differences were not statistically significant. Routine appendectomy was performed in 52 (46.2%) patients with MAE. No mucinous tumor of the appendix was identified. Conclusion: Routine appendectomy is not necessary when the appendix is grossly normal at the time of surgery for MAE. Although the DFS and OS of EEC and MAE patients were similar, the risk of nodal metastasis in MAE patients was greater than that in ECC patients, and we thus suggest to perform retroperitoneal lymphadenectomy (both pelvic and para-aortic) for patients with MAE during the initial operation. Japan Society of Clinical Oncology, 2014 Mucinous endometrial adenocarcinoma nationallicence Endometrioid endometrial carcinoma nationallicence Lymph node metastases nationallicence Appendectomy nationallicence Gungorduk Kemal Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Gaziler Street, 35120, Izmir, Turkey aut Ozdemir Aykut Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Gaziler Street, 35120, Izmir, Turkey aut Ertas Ibrahim Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Gaziler Street, 35120, Izmir, Turkey aut Selcuk Ilker Department of Gynecologic Oncology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey aut Solmaz Ulas Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Gaziler Street, 35120, Izmir, Turkey aut Ozgu Emre Department of Gynecologic Oncology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey aut Mat Emre Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Gaziler Street, 35120, Izmir, Turkey aut Gokcu Mehmet Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Gaziler Street, 35120, Izmir, Turkey aut Karadeniz Tuba Department of Pathology, Tepecik Education and Research Hospital, Izmir, Turkey aut Akbay Serap Department of Pathology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey aut Sanci Muzaffer Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Gaziler Street, 35120, Izmir, Turkey aut Meydanli Mehmet Department of Gynecologic Oncology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey aut Ayaz Duygu Department of Pathology, Tepecik Education and Research Hospital, Izmir, Turkey aut Gungor Tayfun Department of Gynecologic Oncology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey aut International Journal of Clinical Oncology Springer Japan 20/4(2015-08-01), 782-789 1341-9625 20:4<782 2015 20 10147 https://doi.org/10.1007/s10147-014-0767-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10147-014-0767-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gungorduk Kemal Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Gaziler Street, 35120, Izmir, Turkey aut NATIONALLICENCE 700 1- Ozdemir Aykut Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Gaziler Street, 35120, Izmir, Turkey aut NATIONALLICENCE 700 1- Ertas Ibrahim Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Gaziler Street, 35120, Izmir, Turkey aut NATIONALLICENCE 700 1- Selcuk Ilker Department of Gynecologic Oncology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Solmaz Ulas Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Gaziler Street, 35120, Izmir, Turkey aut NATIONALLICENCE 700 1- Ozgu Emre Department of Gynecologic Oncology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Mat Emre Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Gaziler Street, 35120, Izmir, Turkey aut NATIONALLICENCE 700 1- Gokcu Mehmet Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Gaziler Street, 35120, Izmir, Turkey aut NATIONALLICENCE 700 1- Karadeniz Tuba Department of Pathology, Tepecik Education and Research Hospital, Izmir, Turkey aut NATIONALLICENCE 700 1- Akbay Serap Department of Pathology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Sanci Muzaffer Department of Gynecologic Oncology, Tepecik Education and Research Hospital, Gaziler Street, 35120, Izmir, Turkey aut NATIONALLICENCE 700 1- Meydanli Mehmet Department of Gynecologic Oncology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Ayaz Duygu Department of Pathology, Tepecik Education and Research Hospital, Izmir, Turkey aut NATIONALLICENCE 700 1- Gungor Tayfun Department of Gynecologic Oncology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 773 0- International Journal of Clinical Oncology Springer Japan 20/4(2015-08-01), 782-789 1341-9625 20:4<782 2015 20 10147