caa a22 4500 605491399 CHVBK 20210128100509.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s10147-015-0858-8 doi (NATIONALLICENCE)springer-10.1007/s10147-015-0858-8 Recent advances in multidisciplinary approach for rectal cancer [Elektronische Daten] [Eiji Oki, Koji Ando, Yuta Kasagi, Yoko Zaitsu, Masahiko Sugiyama, Yuichiro Nakashima, Hideto Sonoda, Kippei Ohgaki, Hiroshi Saeki, Yoshihiko Maehara] Surgery is a major treatment option for rectal cancer, and total mesorectal excision has been demonstrated to be advantageous in terms of oncological outcome and thus has been the standard surgical approach. Radiotherapy before or after radical surgery is the optimal treatment to control local recurrence of advanced rectal cancer. To date, in many countries, the combination of neoadjuvant concurrent chemotherapy and radiotherapy is considered the standard therapy. A more recent interest in neoadjuvant therapy has been the use of oxaliplatin or targeted agents for neoadjuvant chemoradiotherapy. However, despite many trials of oxaliplatin and targeted agents, 5-FU-based concurrent chemoradiotherapy has remained the only standard treatment option. Postoperative adjuvant chemotherapy with neoadjuvant chemoradiotherapy or induction chemotherapy with neoadjuvant chemoradiotherapy may further improve patient survival, as some clinical studies recently indicated. In Japan, neoadjuvant therapy is not the standard treatment method, because surgery with lateral lymph node dissection is usually performed and this type of surgery may reduce recurrence rate as does radiation therapy. The phase III study to evaluate the oncological effect of the Japanese standard operation (mesorectal excision, ME) with lateral lymph node dissection in comparison with ME alone for clinical stage II and III lower rectal cancer is currently ongoing. Japan Society of Clinical Oncology, 2015 Rectal cancer nationallicence Neoadjuvant chemoradiotherapy nationallicence Total mesorectal excision nationallicence Adjuvant chemotherapy nationallicence Oki Eiji Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan aut Ando Koji Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan aut Kasagi Yuta Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan aut Zaitsu Yoko Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan aut Sugiyama Masahiko Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan aut Nakashima Yuichiro Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan aut Sonoda Hideto Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan aut Ohgaki Kippei Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan aut Saeki Hiroshi Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan aut Maehara Yoshihiko Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan aut International Journal of Clinical Oncology Springer Japan 20/4(2015-08-01), 641-649 1341-9625 20:4<641 2015 20 10147 https://doi.org/10.1007/s10147-015-0858-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10147-015-0858-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Oki Eiji Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan aut NATIONALLICENCE 700 1- Ando Koji Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan aut NATIONALLICENCE 700 1- Kasagi Yuta Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan aut NATIONALLICENCE 700 1- Zaitsu Yoko Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan aut NATIONALLICENCE 700 1- Sugiyama Masahiko Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan aut NATIONALLICENCE 700 1- Nakashima Yuichiro Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan aut NATIONALLICENCE 700 1- Sonoda Hideto Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan aut NATIONALLICENCE 700 1- Ohgaki Kippei Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan aut NATIONALLICENCE 700 1- Saeki Hiroshi Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan aut NATIONALLICENCE 700 1- Maehara Yoshihiko Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan aut NATIONALLICENCE 773 0- International Journal of Clinical Oncology Springer Japan 20/4(2015-08-01), 641-649 1341-9625 20:4<641 2015 20 10147