Long-term results of definitive concurrent chemoradiotherapy for patients with esophageal submucosal cancer (T1bN0M0)
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| 024 | 7 | 0 | |a 10.1007/s10147-015-0819-2 |2 doi |
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| 245 | 0 | 0 | |a Long-term results of definitive concurrent chemoradiotherapy for patients with esophageal submucosal cancer (T1bN0M0) |h [Elektronische Daten] |c [Yuji Murakami, Ippei Takahashi, Ikuno Nishibuchi, Yoshiko Doi, Tomoyuki Okabe, Masahiro Kenjo, Tomoki Kimura, Yasushi Nagata] |
| 520 | 3 | |a Background: The long-term outcomes of definitive concurrent chemoradiotherapy for patients with esophageal submucosal cancer without regional and distant metastasis were retrospectively analyzed. Methods: Patients with histologically confirmed esophageal submucosal cancers without regional and distant metastasis who received definitive concurrent chemoradiotherapy from 2001 to 2011 were included. Radiation therapy of a median total dose of 60Gy/30 fractions (range, 54-66Gy) with elective nodal irradiation of 40Gy was combined concurrently with 5-furuorouracil-based chemotherapy. Results: Thirty-six patients (33 men and 3 women) aged from 45 to 80years (median, 67 years) were assessed. All patients had squamous cell carcinoma. With a median follow-up time of 61months, the 5-year overall survival, disease-free survival, and locoregional failure-free survival rates were 86% [95% confidence interval (CI), 74-99%], 59% (95% CI, 42-77%), and 90% (95% CI, 79-100%), respectively. Late toxicities of grade 3 pleural effusion in 2 patients, grade 4 pericardial effusion in 1 patient, and grade 5 pneumonitis in 1 patient were observed. Metachronous esophageal cancer was observed in 8 patients (22%). Among them, 6 patients with mucosal legions were salvaged by endoscopic resection. Conclusion: Our long-term results of concurrent chemoradiotherapy (CCRT) for patients with esophageal submucosal cancer showed acceptable toxicities and favorable locoregional control and survivals while maintaining organ preservation. | |
| 540 | |a Japan Society of Clinical Oncology, 2015 | ||
| 690 | 7 | |a Esophageal cancer |2 nationallicence | |
| 690 | 7 | |a Submucosal cancer |2 nationallicence | |
| 690 | 7 | |a Chemoradiotherapy |2 nationallicence | |
| 700 | 1 | |a Murakami |D Yuji |u Department of Radiation Oncology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, 734-8551, Hiroshima, Japan |4 aut | |
| 700 | 1 | |a Takahashi |D Ippei |u Department of Radiation Oncology, Hiroshima Red Cross Hospital and Atomic-Bomb Survivors Hospital, 1-9-6 Senda-machi, Naka-ku, 730-8619, Hiroshima, Japan |4 aut | |
| 700 | 1 | |a Nishibuchi |D Ikuno |u Department of Radiation Oncology, Hiroshima Prefectural Hospital, Ujinakanda Minami-ku, 734-8530, Hiroshima, Japan |4 aut | |
| 700 | 1 | |a Doi |D Yoshiko |u Department of Radiation Oncology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, 734-8551, Hiroshima, Japan |4 aut | |
| 700 | 1 | |a Okabe |D Tomoyuki |u Department of Radiation Oncology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, 734-8551, Hiroshima, Japan |4 aut | |
| 700 | 1 | |a Kenjo |D Masahiro |u Department of Radiation Oncology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, 734-8551, Hiroshima, Japan |4 aut | |
| 700 | 1 | |a Kimura |D Tomoki |u Department of Radiation Oncology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, 734-8551, Hiroshima, Japan |4 aut | |
| 700 | 1 | |a Nagata |D Yasushi |u Department of Radiation Oncology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, 734-8551, Hiroshima, Japan |4 aut | |
| 773 | 0 | |t International Journal of Clinical Oncology |d Springer Japan |g 20/5(2015-10-01), 897-904 |x 1341-9625 |q 20:5<897 |1 2015 |2 20 |o 10147 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10147-015-0819-2 |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10147-015-0819-2 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Murakami |D Yuji |u Department of Radiation Oncology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, 734-8551, Hiroshima, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Takahashi |D Ippei |u Department of Radiation Oncology, Hiroshima Red Cross Hospital and Atomic-Bomb Survivors Hospital, 1-9-6 Senda-machi, Naka-ku, 730-8619, Hiroshima, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nishibuchi |D Ikuno |u Department of Radiation Oncology, Hiroshima Prefectural Hospital, Ujinakanda Minami-ku, 734-8530, Hiroshima, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Doi |D Yoshiko |u Department of Radiation Oncology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, 734-8551, Hiroshima, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Okabe |D Tomoyuki |u Department of Radiation Oncology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, 734-8551, Hiroshima, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kenjo |D Masahiro |u Department of Radiation Oncology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, 734-8551, Hiroshima, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kimura |D Tomoki |u Department of Radiation Oncology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, 734-8551, Hiroshima, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nagata |D Yasushi |u Department of Radiation Oncology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, 734-8551, Hiroshima, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t International Journal of Clinical Oncology |d Springer Japan |g 20/5(2015-10-01), 897-904 |x 1341-9625 |q 20:5<897 |1 2015 |2 20 |o 10147 | ||