FOXP3 autoantibody as a potential early prognostic serum biomarker in patients with cervical cancer
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| 024 | 7 | 0 | |a 10.1007/s10147-015-0797-4 |2 doi |
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| 245 | 0 | 0 | |a FOXP3 autoantibody as a potential early prognostic serum biomarker in patients with cervical cancer |h [Elektronische Daten] |c [Shuang Xu, Mingmei Huangfu, Xueli Jia, Xiaowei Song, Baosheng Sun, Kuang-Hui Lee, Linlin Liu, Shilong Sun] |
| 520 | 3 | |a Background: Overexpression of tumor-associated antigens has been reported in many types of cancer and may trigger secretion of their autoantibodies. The present work was designed to test whether circulating antibody to FOXP3 protein-derived antigens was altered in early cervical cancer and cervical benign tumors. Methods: A total of 141 patients with cervical cancer, 133 patients with cervical benign tumors and 148 healthy age-matched volunteers were recruited. The level of circulating anti-FOXP3 IgG antibody was tested using an enzyme-linked immunosorbent assay developed in-house with linear peptide antigens derived from FOXP3 protein. The linear peptide antigens were designed according to the computational prediction of HLA-II epitopes. Results: Student's t test showed that anti-FOXP3 IgG in the malignant tumor group and the benign tumor group was significantly higher than in the control group (t=6.127, p<0.001; t=2.704, p=0.007). In addition, patients with stage I cervical cancer (t=2.968, p=0.003) had a significantly higher level of FOXP3 autoantibodies than patients with benign tumors. The sensitivity against >90% specificity was 20.6% with an interassay deviation of 11.7% in the cervical cancer group. Based on a cut-off value determined by the 98th percentile of the control group IgG levels, the anti-FOXP3 IgG positivity was 2.1% in patients with cervical cancer compared to 2.0% in the health controls (chi-squared=0.004, p=0.952, OR=1.051, 95% CI 0.209-5.295). Conclusion: The circulating autoantibody to FOXP3 reflecting the continuous development of the cervical lesion, may be a potential biomarker with early prognostic values for cervical cancer. | |
| 540 | |a Japan Society of Clinical Oncology, 2015 | ||
| 690 | 7 | |a Autoantibody |2 nationallicence | |
| 690 | 7 | |a Biomarkers |2 nationallicence | |
| 690 | 7 | |a Cervical cancer |2 nationallicence | |
| 690 | 7 | |a FOXP3 |2 nationallicence | |
| 690 | 7 | |a Tumor immunity |2 nationallicence | |
| 700 | 1 | |a Xu |D Shuang |u Department of Radiotherapy, Second Hospital of Jilin University, 130041, Changchun, China |4 aut | |
| 700 | 1 | |a Huangfu |D Mingmei |u Department of Radiotherapy, Second Hospital of Jilin University, 130041, Changchun, China |4 aut | |
| 700 | 1 | |a Jia |D Xueli |u Department of Radiotherapy, Second Hospital of Jilin University, 130041, Changchun, China |4 aut | |
| 700 | 1 | |a Song |D Xiaowei |u Ministry of Health Key Laboratory of Radiobiology, Jilin University, 130021, Changchun, China |4 aut | |
| 700 | 1 | |a Sun |D Baosheng |u Department of Radiotherapy, Tumor Hospital of Jilin Province, 130012, Changchun, China |4 aut | |
| 700 | 1 | |a Lee |D Kuang-Hui |u Pei-Ling Guan-Si Hospital, Hsin-Fu Kuansi Township, 30647, Hsinchu County, Taiwan |4 aut | |
| 700 | 1 | |a Liu |D Linlin |u Department of Radiotherapy, Second Hospital of Jilin University, 130041, Changchun, China |4 aut | |
| 700 | 1 | |a Sun |D Shilong |u Ministry of Health Key Laboratory of Radiobiology, Jilin University, 130021, Changchun, China |4 aut | |
| 773 | 0 | |t International Journal of Clinical Oncology |d Springer Japan |g 20/5(2015-10-01), 982-988 |x 1341-9625 |q 20:5<982 |1 2015 |2 20 |o 10147 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10147-015-0797-4 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10147-015-0797-4 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Xu |D Shuang |u Department of Radiotherapy, Second Hospital of Jilin University, 130041, Changchun, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Huangfu |D Mingmei |u Department of Radiotherapy, Second Hospital of Jilin University, 130041, Changchun, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Jia |D Xueli |u Department of Radiotherapy, Second Hospital of Jilin University, 130041, Changchun, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Song |D Xiaowei |u Ministry of Health Key Laboratory of Radiobiology, Jilin University, 130021, Changchun, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sun |D Baosheng |u Department of Radiotherapy, Tumor Hospital of Jilin Province, 130012, Changchun, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lee |D Kuang-Hui |u Pei-Ling Guan-Si Hospital, Hsin-Fu Kuansi Township, 30647, Hsinchu County, Taiwan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Liu |D Linlin |u Department of Radiotherapy, Second Hospital of Jilin University, 130041, Changchun, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sun |D Shilong |u Ministry of Health Key Laboratory of Radiobiology, Jilin University, 130021, Changchun, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t International Journal of Clinical Oncology |d Springer Japan |g 20/5(2015-10-01), 982-988 |x 1341-9625 |q 20:5<982 |1 2015 |2 20 |o 10147 | ||