The pretreatment neutrophil-to-lymphocyte ratio predicts therapeutic response to radiation therapy and concurrent chemoradiation therapy in uterine cervical cancer
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| 024 | 7 | 0 | |a 10.1007/s10147-015-0807-6 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10147-015-0807-6 | ||
| 245 | 0 | 4 | |a The pretreatment neutrophil-to-lymphocyte ratio predicts therapeutic response to radiation therapy and concurrent chemoradiation therapy in uterine cervical cancer |h [Elektronische Daten] |c [Makito Mizunuma, Yoshihito Yokoyama, Masayuki Futagami, Masahiko Aoki, Yoshihiro Takai, Hideki Mizunuma] |
| 520 | 3 | |a Background: The aim of this study was to investigate the prognostic role of the pretreatment neutrophil-to-lymphocyte ratio (NLR) as a predictive marker prior to treatment ofcervical cancer with radiation therapy (RT) alone or concurrent chemoradiation therapy (CCRT). Methods: Fifty-six patients with squamous cell carcinoma (SCC) of the uterine cervix who underwent RT or CCRT from 2005−2013 at the Hirosaki University Hospital were retrospectively identified using electronic databases. Patients were divided into a high NLR group (≥2.5) and a low NLR group (<2.5). The efficacy of RT and CCRT in the two groups was compared. Result: Of the 56 patients, 35 were in the high NLR group and 21 were in the low NLR group. In comparison to a high NLR, a low NLR was significantly associated with a complete response (P<0.001). When cancer was divided into stages I/II and III/IV, patients with a low NLR had a significantly better therapeutic outcome than those with a high NLR (P<0.05). Multivariate analysis showed that only the NLR was a significant prognostic factor for progression-free survival (PFS) and overall survival (OS). Patients with a high NLR had significantly shorter PFS and OS than those with a low NLR. Conclusion: Results showed that a low NLR before treatment could predict a good response to RT or CCRT at all stages of uterine cervical cancer. The NLR may be a promising parameter on which to base the choice of a therapeutic strategy to treat SCC of the uterine cervix. | |
| 540 | |a Japan Society of Clinical Oncology, 2015 | ||
| 690 | 7 | |a NLR |2 nationallicence | |
| 690 | 7 | |a Uterine cervical cancer |2 nationallicence | |
| 690 | 7 | |a Radiation therapy |2 nationallicence | |
| 690 | 7 | |a Concurrent chemoradiation therapy |2 nationallicence | |
| 690 | 7 | |a Therapeutic outcome |2 nationallicence | |
| 700 | 1 | |a Mizunuma |D Makito |u Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, 036-8562, Hirosaki, Aomori, Japan |4 aut | |
| 700 | 1 | |a Yokoyama |D Yoshihito |u Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, 036-8562, Hirosaki, Aomori, Japan |4 aut | |
| 700 | 1 | |a Futagami |D Masayuki |u Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, 036-8562, Hirosaki, Aomori, Japan |4 aut | |
| 700 | 1 | |a Aoki |D Masahiko |u Department of Radiology and Radiation Oncology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, 036-8562, Hirosaki, Japan |4 aut | |
| 700 | 1 | |a Takai |D Yoshihiro |u Department of Radiology and Radiation Oncology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, 036-8562, Hirosaki, Japan |4 aut | |
| 700 | 1 | |a Mizunuma |D Hideki |u Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, 036-8562, Hirosaki, Aomori, Japan |4 aut | |
| 773 | 0 | |t International Journal of Clinical Oncology |d Springer Japan |g 20/5(2015-10-01), 989-996 |x 1341-9625 |q 20:5<989 |1 2015 |2 20 |o 10147 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10147-015-0807-6 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10147-015-0807-6 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Mizunuma |D Makito |u Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, 036-8562, Hirosaki, Aomori, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yokoyama |D Yoshihito |u Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, 036-8562, Hirosaki, Aomori, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Futagami |D Masayuki |u Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, 036-8562, Hirosaki, Aomori, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Aoki |D Masahiko |u Department of Radiology and Radiation Oncology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, 036-8562, Hirosaki, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Takai |D Yoshihiro |u Department of Radiology and Radiation Oncology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, 036-8562, Hirosaki, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Mizunuma |D Hideki |u Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, 036-8562, Hirosaki, Aomori, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t International Journal of Clinical Oncology |d Springer Japan |g 20/5(2015-10-01), 989-996 |x 1341-9625 |q 20:5<989 |1 2015 |2 20 |o 10147 | ||