caa a22 4500 605491445 CHVBK 20210128100510.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10147-015-0807-6 doi (NATIONALLICENCE)springer-10.1007/s10147-015-0807-6 The pretreatment neutrophil-to-lymphocyte ratio predicts therapeutic response to radiation therapy and concurrent chemoradiation therapy in uterine cervical cancer [Elektronische Daten] [Makito Mizunuma, Yoshihito Yokoyama, Masayuki Futagami, Masahiko Aoki, Yoshihiro Takai, Hideki Mizunuma] Background: The aim of this study was to investigate the prognostic role of the pretreatment neutrophil-to-lymphocyte ratio (NLR) as a predictive marker prior to treatment ofcervical cancer with radiation therapy (RT) alone or concurrent chemoradiation therapy (CCRT). Methods: Fifty-six patients with squamous cell carcinoma (SCC) of the uterine cervix who underwent RT or CCRT from 2005−2013 at the Hirosaki University Hospital were retrospectively identified using electronic databases. Patients were divided into a high NLR group (≥2.5) and a low NLR group (<2.5). The efficacy of RT and CCRT in the two groups was compared. Result: Of the 56 patients, 35 were in the high NLR group and 21 were in the low NLR group. In comparison to a high NLR, a low NLR was significantly associated with a complete response (P<0.001). When cancer was divided into stages I/II and III/IV, patients with a low NLR had a significantly better therapeutic outcome than those with a high NLR (P<0.05). Multivariate analysis showed that only the NLR was a significant prognostic factor for progression-free survival (PFS) and overall survival (OS). Patients with a high NLR had significantly shorter PFS and OS than those with a low NLR. Conclusion: Results showed that a low NLR before treatment could predict a good response to RT or CCRT at all stages of uterine cervical cancer. The NLR may be a promising parameter on which to base the choice of a therapeutic strategy to treat SCC of the uterine cervix. Japan Society of Clinical Oncology, 2015 NLR nationallicence Uterine cervical cancer nationallicence Radiation therapy nationallicence Concurrent chemoradiation therapy nationallicence Therapeutic outcome nationallicence Mizunuma Makito Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, 036-8562, Hirosaki, Aomori, Japan aut Yokoyama Yoshihito Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, 036-8562, Hirosaki, Aomori, Japan aut Futagami Masayuki Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, 036-8562, Hirosaki, Aomori, Japan aut Aoki Masahiko Department of Radiology and Radiation Oncology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, 036-8562, Hirosaki, Japan aut Takai Yoshihiro Department of Radiology and Radiation Oncology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, 036-8562, Hirosaki, Japan aut Mizunuma Hideki Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, 036-8562, Hirosaki, Aomori, Japan aut International Journal of Clinical Oncology Springer Japan 20/5(2015-10-01), 989-996 1341-9625 20:5<989 2015 20 10147 https://doi.org/10.1007/s10147-015-0807-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10147-015-0807-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mizunuma Makito Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, 036-8562, Hirosaki, Aomori, Japan aut NATIONALLICENCE 700 1- Yokoyama Yoshihito Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, 036-8562, Hirosaki, Aomori, Japan aut NATIONALLICENCE 700 1- Futagami Masayuki Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, 036-8562, Hirosaki, Aomori, Japan aut NATIONALLICENCE 700 1- Aoki Masahiko Department of Radiology and Radiation Oncology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, 036-8562, Hirosaki, Japan aut NATIONALLICENCE 700 1- Takai Yoshihiro Department of Radiology and Radiation Oncology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, 036-8562, Hirosaki, Japan aut NATIONALLICENCE 700 1- Mizunuma Hideki Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, 036-8562, Hirosaki, Aomori, Japan aut NATIONALLICENCE 773 0- International Journal of Clinical Oncology Springer Japan 20/5(2015-10-01), 989-996 1341-9625 20:5<989 2015 20 10147