caa a22 4500 605491461 CHVBK 20210128100510.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10147-015-0803-x doi (NATIONALLICENCE)springer-10.1007/s10147-015-0803-x Investigation of the clinicopathological features of squamous cell carcinoma of the vulva: a retrospective survey of the Tohoku Gynecologic Cancer Unit [Elektronische Daten] [Masayuki Futagami, Yoshihito Yokoyama, Kaori Iino, Masahiko Aoki, Tadahiro Shoji, Toru Sugiyama, Hisanori Ariga, Hideki Tokunaga, Tadao Takano, Yoh Watanabe, Nobuo Yaegashi, Keiichi Jingu, Naoki Sato, Yukihiro Terada, Akira Anbai, Tsuyoshi Ohta, Hirohisa Kurachi, Yuuki Kuroda, Hiroshi Nishiyama, Keiya Fujimori, Takafumi Watanabe, Hisashi Sato, Toru Tase, Hitoshi Wada, Hideki Mizunuma] Background: This multi-institutional study was conducted to clarify the clinicopathological features of squamous cell carcinomas of the vulva. Methods: The medical records of vulvar cancer patients treated between 2002 and 2012 were retrospectively reviewed following approval by the Institutional Review Board of each institution. Results: One hundred and eleven patients with vulvar malignancies were included. Of these, 63 patients had squamous cell carcinoma (57%). Initial treatment was surgery, radiation therapy (RT), and concurrent chemoradiotherapy (CCRT) in 34 (54%), 15 (24%), and 11 (17%) patients, respectively. Nineteen, 11, 26, and 7 patients had stage I, II, III, and IV disease, respectively. Of the 34 patients who had surgical treatment, 50% had stage I disease, while 74% of those who received CCRT had stage III or IV disease. Complete response (CR) rates for the surgery, RT, and CCRT groups were 73, 60, and 64%, respectively. The 5-year survival rates for stage I/II and III/IV disease were 64 and 39%, respectively (P=0.019). The 5-year survival rates for the surgery, RT, and CCRT groups were 53, 38, and 50%, respectively, and the prognosis of patients treated with surgery or CCRT was significantly better than that of patients who received RT (P<0.05). In multivariate analysis, clinical response to initial treatment was an independent prognostic factor (P<0.001). Conclusions: Although many patients had advanced-stage disease in the CCRT group, the therapeutic outcome for the surgery and CCRT groups was similar. Thus, CCRT may be a promising treatment for squamous cell carcinoma of the vulva. Japan Society of Clinical Oncology, 2015 Squamous cell carcinoma of the vulva nationallicence Surgery nationallicence CCRT nationallicence Prognosis nationallicence Futagami Masayuki Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, 036-8562, Hirosaki, Aomori, Japan aut Yokoyama Yoshihito Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, 036-8562, Hirosaki, Aomori, Japan aut Iino Kaori Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, 036-8562, Hirosaki, Aomori, Japan aut Aoki Masahiko Department of Radiology and Radiation Oncology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, 036-8562, Hirosaki, Aomori, Japan aut Shoji Tadahiro Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine, Morioka, Japan aut Sugiyama Toru Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine, Morioka, Japan aut Ariga Hisanori Department of Radiation Oncology, Iwate Medical University School of Medicine, Morioka, Japan aut Tokunaga Hideki Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan aut Takano Tadao Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan aut Watanabe Yoh Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan aut Yaegashi Nobuo Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan aut Jingu Keiichi Department of Radiation Oncology, Tohoku University Graduate School of Medicine, Sendai, Japan aut Sato Naoki Department of Obstetrics and Gynecology, Akita University Graduate School of Medicine, Akita, Japan aut Terada Yukihiro Department of Obstetrics and Gynecology, Akita University Graduate School of Medicine, Akita, Japan aut Anbai Akira Department of Radiology and Radiation Oncology, Akita University Graduate School of Medicine, Akita, Japan aut Ohta Tsuyoshi Department of Obstetrics and Gynecology, Yamagata University Faculty of Medicine, Yamagata, Japan aut Kurachi Hirohisa Department of Obstetrics and Gynecology, Yamagata University Faculty of Medicine, Yamagata, Japan aut Kuroda Yuuki Department of Radiation Oncology, Yamagata University Faculty of Medicine, Yamagata, Japan aut Nishiyama Hiroshi Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan aut Fujimori Keiya Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan aut Watanabe Takafumi Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan aut Sato Hisashi Department of Radiation Oncology, Fukushima Medical University School of Medicine, Fukushima, Japan aut Tase Toru Department of Gynecology, Miyagi Cancer Center, Natori, Japan aut Wada Hitoshi Department of Radiation Oncology, Miyagi Cancer Center, Natori, Japan aut Mizunuma Hideki Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, 036-8562, Hirosaki, Aomori, Japan aut International Journal of Clinical Oncology Springer Japan 20/5(2015-10-01), 1005-1011 1341-9625 20:5<1005 2015 20 10147 https://doi.org/10.1007/s10147-015-0803-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10147-015-0803-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Futagami Masayuki Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, 036-8562, Hirosaki, Aomori, Japan aut NATIONALLICENCE 700 1- Yokoyama Yoshihito Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, 036-8562, Hirosaki, Aomori, Japan aut NATIONALLICENCE 700 1- Iino Kaori Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, 036-8562, Hirosaki, Aomori, Japan aut NATIONALLICENCE 700 1- Aoki Masahiko Department of Radiology and Radiation Oncology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, 036-8562, Hirosaki, Aomori, Japan aut NATIONALLICENCE 700 1- Shoji Tadahiro Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine, Morioka, Japan aut NATIONALLICENCE 700 1- Sugiyama Toru Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine, Morioka, Japan aut NATIONALLICENCE 700 1- Ariga Hisanori Department of Radiation Oncology, Iwate Medical University School of Medicine, Morioka, Japan aut NATIONALLICENCE 700 1- Tokunaga Hideki Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan aut NATIONALLICENCE 700 1- Takano Tadao Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan aut NATIONALLICENCE 700 1- Watanabe Yoh Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan aut NATIONALLICENCE 700 1- Yaegashi Nobuo Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan aut NATIONALLICENCE 700 1- Jingu Keiichi Department of Radiation Oncology, Tohoku University Graduate School of Medicine, Sendai, Japan aut NATIONALLICENCE 700 1- Sato Naoki Department of Obstetrics and Gynecology, Akita University Graduate School of Medicine, Akita, Japan aut NATIONALLICENCE 700 1- Terada Yukihiro Department of Obstetrics and Gynecology, Akita University Graduate School of Medicine, Akita, Japan aut NATIONALLICENCE 700 1- Anbai Akira Department of Radiology and Radiation Oncology, Akita University Graduate School of Medicine, Akita, Japan aut NATIONALLICENCE 700 1- Ohta Tsuyoshi Department of Obstetrics and Gynecology, Yamagata University Faculty of Medicine, Yamagata, Japan aut NATIONALLICENCE 700 1- Kurachi Hirohisa Department of Obstetrics and Gynecology, Yamagata University Faculty of Medicine, Yamagata, Japan aut NATIONALLICENCE 700 1- Kuroda Yuuki Department of Radiation Oncology, Yamagata University Faculty of Medicine, Yamagata, Japan aut NATIONALLICENCE 700 1- Nishiyama Hiroshi Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan aut NATIONALLICENCE 700 1- Fujimori Keiya Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan aut NATIONALLICENCE 700 1- Watanabe Takafumi Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan aut NATIONALLICENCE 700 1- Sato Hisashi Department of Radiation Oncology, Fukushima Medical University School of Medicine, Fukushima, Japan aut NATIONALLICENCE 700 1- Tase Toru Department of Gynecology, Miyagi Cancer Center, Natori, Japan aut NATIONALLICENCE 700 1- Wada Hitoshi Department of Radiation Oncology, Miyagi Cancer Center, Natori, Japan aut NATIONALLICENCE 700 1- Mizunuma Hideki Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, 036-8562, Hirosaki, Aomori, Japan aut NATIONALLICENCE 773 0- International Journal of Clinical Oncology Springer Japan 20/5(2015-10-01), 1005-1011 1341-9625 20:5<1005 2015 20 10147