The usefulness of 18F-FDG-PET/CT in discriminating benign from malignant ovarian teratomas
| LEADER | caa a22 4500 | ||
|---|---|---|---|
| 001 | 605491542 | ||
| 003 | CHVBK | ||
| 005 | 20210128100510.0 | ||
| 007 | cr unu---uuuuu | ||
| 008 | 210128e20151001xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1007/s10147-015-0800-0 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10147-015-0800-0 | ||
| 245 | 0 | 4 | |a The usefulness of 18F-FDG-PET/CT in discriminating benign from malignant ovarian teratomas |h [Elektronische Daten] |c [Takanori Yokoyama, Kazuhiro Takehara, Yasuko Yamamoto, Shinichi Okame, Yuko Shiroyama, Takashi Yokoyama, Takayoshi Nogawa, Yosifumi Sugawara] |
| 520 | 3 | |a Background: The present study investigates the usefulness of 18F-FDG-PET/CT (PET/CT) in distinguishing between benign and malignant ovarian teratomas. Methods: This study includes 4 mature teratomas (MTs) with malignant transformation, 8 immature teratomas (ITs), and 16 MTs that were diagnosed after surgical resection. Preoperative tumor marker values, MRI findings, PET/CT SUVmax values, and other clinical parameters were retrospectively compared with those of 14 patients who had MTs. Results: The median CA125 was significantly higher for ITs than for MTs (P=0.04). The median AFP was significantly higher for ITs than for MTs (P=0.0034). The median SUVmax values for MTs with malignant transformation, ITs, and MTs were 18.3 (5.3-23.3), 6.0 (3.6-22.6), and 1.1 (1.0-15.5), respectively. SUVmax was significantly higher in MTs with malignant transformation and ITs than in MTs (P=0.004, P=0.0007). With a cut-off SUVmax of 3.6 to distinguish between benign and malignant MTs, sensitivity was 100%, specificity was 81%, positive predictive value was 80%, negative predictive value was 100%, and diagnostic accuracy was 89% (AUC 0.94). However, one patient with an MT had a high SUVmax corresponding to values in the central nervous system (CNS). Conclusions: 18F-FDG-PET/CT has a high diagnostic accuracy in distinguishing between benign and malignant ovarian teratomas. Thus, PET/CT may be useful in cases where the diagnosis is unclear on MRI and other clinical findings. However, some MTs with abundant CNS tissue may have a high SUVmax. Therefore, the diagnosis of a benign or malignant lesion should be made carefully in conjunction with other clinical findings. | |
| 540 | |a Japan Society of Clinical Oncology, 2015 | ||
| 690 | 7 | |a FDG-PET/CT |2 nationallicence | |
| 690 | 7 | |a SUVmax |2 nationallicence | |
| 690 | 7 | |a Teratoma |2 nationallicence | |
| 690 | 7 | |a Malignant transformation |2 nationallicence | |
| 690 | 7 | |a Immature teratoma |2 nationallicence | |
| 700 | 1 | |a Yokoyama |D Takanori |u Department of Gynecologic Oncology, National Hospital Organization, Shikoku Cancer Center, Ko-160 Minamiumemoto, 791-0280, Matsuyama, Japan |4 aut | |
| 700 | 1 | |a Takehara |D Kazuhiro |u Department of Gynecologic Oncology, National Hospital Organization, Shikoku Cancer Center, Ko-160 Minamiumemoto, 791-0280, Matsuyama, Japan |4 aut | |
| 700 | 1 | |a Yamamoto |D Yasuko |u Department of Gynecologic Oncology, National Hospital Organization, Shikoku Cancer Center, Ko-160 Minamiumemoto, 791-0280, Matsuyama, Japan |4 aut | |
| 700 | 1 | |a Okame |D Shinichi |u Department of Gynecologic Oncology, National Hospital Organization, Shikoku Cancer Center, Ko-160 Minamiumemoto, 791-0280, Matsuyama, Japan |4 aut | |
| 700 | 1 | |a Shiroyama |D Yuko |u Department of Gynecologic Oncology, National Hospital Organization, Shikoku Cancer Center, Ko-160 Minamiumemoto, 791-0280, Matsuyama, Japan |4 aut | |
| 700 | 1 | |a Yokoyama |D Takashi |u Department of Gynecologic Oncology, National Hospital Organization, Shikoku Cancer Center, Ko-160 Minamiumemoto, 791-0280, Matsuyama, Japan |4 aut | |
| 700 | 1 | |a Nogawa |D Takayoshi |u Department of Gynecologic Oncology, National Hospital Organization, Shikoku Cancer Center, Ko-160 Minamiumemoto, 791-0280, Matsuyama, Japan |4 aut | |
| 700 | 1 | |a Sugawara |D Yosifumi |u Department of Diagnostic Radiology, National Hospital Organization, Shikoku Cancer Center, Ko-160 Minamiumemoto, 791-0280, Matsuyama, Japan |4 aut | |
| 773 | 0 | |t International Journal of Clinical Oncology |d Springer Japan |g 20/5(2015-10-01), 960-966 |x 1341-9625 |q 20:5<960 |1 2015 |2 20 |o 10147 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10147-015-0800-0 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10147-015-0800-0 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yokoyama |D Takanori |u Department of Gynecologic Oncology, National Hospital Organization, Shikoku Cancer Center, Ko-160 Minamiumemoto, 791-0280, Matsuyama, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Takehara |D Kazuhiro |u Department of Gynecologic Oncology, National Hospital Organization, Shikoku Cancer Center, Ko-160 Minamiumemoto, 791-0280, Matsuyama, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yamamoto |D Yasuko |u Department of Gynecologic Oncology, National Hospital Organization, Shikoku Cancer Center, Ko-160 Minamiumemoto, 791-0280, Matsuyama, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Okame |D Shinichi |u Department of Gynecologic Oncology, National Hospital Organization, Shikoku Cancer Center, Ko-160 Minamiumemoto, 791-0280, Matsuyama, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Shiroyama |D Yuko |u Department of Gynecologic Oncology, National Hospital Organization, Shikoku Cancer Center, Ko-160 Minamiumemoto, 791-0280, Matsuyama, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yokoyama |D Takashi |u Department of Gynecologic Oncology, National Hospital Organization, Shikoku Cancer Center, Ko-160 Minamiumemoto, 791-0280, Matsuyama, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nogawa |D Takayoshi |u Department of Gynecologic Oncology, National Hospital Organization, Shikoku Cancer Center, Ko-160 Minamiumemoto, 791-0280, Matsuyama, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sugawara |D Yosifumi |u Department of Diagnostic Radiology, National Hospital Organization, Shikoku Cancer Center, Ko-160 Minamiumemoto, 791-0280, Matsuyama, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t International Journal of Clinical Oncology |d Springer Japan |g 20/5(2015-10-01), 960-966 |x 1341-9625 |q 20:5<960 |1 2015 |2 20 |o 10147 | ||