caa a22 4500 605491585 CHVBK 20210128100510.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10147-015-0817-4 doi (NATIONALLICENCE)springer-10.1007/s10147-015-0817-4 Fluorodeoxyglucose positron emission tomography/computed tomography for diagnosis of upper urinary tract urothelial carcinoma [Elektronische Daten] [Seiji Asai, Tetsuya Fukumoto, Nozomu Tanji, Noriyoshi Miura, Masao Miyagawa, Kenichi Nishimura, Yutaka Yanagihara, Akitomi Shirato, Yuki Miyauchi, Tadahiko Kikugawa, Masayoshi Yokoyama] Background: The purpose of this study was to assess the ability of fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) to detect upper urinary tract urothelial carcinomas (UTUC) compared with pathological examination of tissues obtained by ureteroscopic biopsy and split cytologic analysis of urine obtained after retrograde pyelography. Methods: Clinicopathological records of patients at our institution were retrospectively reviewed. Fifty patients with clinically suspected UTUC, who were histologically diagnosed by nephroureterectomy, partial ureterectomy, or endoscopic biopsy, were included. The patient cohort included 42 men and 8 women, with a median age of 73 (range 54-92) years. Results: Only 27% of 49 patients with UTUC had positive voided urine cytology, and 33% of 40 patients had positive split urine cytology. In addition, 40% of 10 patients had a positive endoscopic biopsy. However, 83% of 48 patients with UTUC had positive results from FDG-PET/CT examination. The positive predictive value of FDG-PET/CT was 95%. There were no correlations between sensitivity and tumor stage or tumor grade. Sensitivity of FDG-PET/CT for patients with and without diabetes mellitus was 60 and 89%, respectively. Conclusions: These preliminary results from a small number of patients revealed that FDG-PET/CT enabled effective detection of UTUC. Japan Society of Clinical Oncology, 2015 FDG-PET/CT nationallicence Upper urinary tract urothelial carcinoma nationallicence Urine cytology nationallicence Ureteroscopy nationallicence Asai Seiji Department of Urology, Ehime University Graduate School of Medicine, Shitsukawa, 791-0295, Toon, Ehime, Japan aut Fukumoto Tetsuya Department of Urology, Ehime University Graduate School of Medicine, Shitsukawa, 791-0295, Toon, Ehime, Japan aut Tanji Nozomu Department of Urology, Ehime University Graduate School of Medicine, Shitsukawa, 791-0295, Toon, Ehime, Japan aut Miura Noriyoshi Department of Urology, Ehime University Graduate School of Medicine, Shitsukawa, 791-0295, Toon, Ehime, Japan aut Miyagawa Masao Department of Diagnostic and Therapeutic Radiology, Ehime University Graduate School of Medicine, 791-0295, Toon, Ehime, Japan aut Nishimura Kenichi Department of Urology, Ehime University Graduate School of Medicine, Shitsukawa, 791-0295, Toon, Ehime, Japan aut Yanagihara Yutaka Department of Urology, Ehime University Graduate School of Medicine, Shitsukawa, 791-0295, Toon, Ehime, Japan aut Shirato Akitomi Department of Urology, Ehime University Graduate School of Medicine, Shitsukawa, 791-0295, Toon, Ehime, Japan aut Miyauchi Yuki Department of Urology, Ehime University Graduate School of Medicine, Shitsukawa, 791-0295, Toon, Ehime, Japan aut Kikugawa Tadahiko Department of Urology, Ehime University Graduate School of Medicine, Shitsukawa, 791-0295, Toon, Ehime, Japan aut Yokoyama Masayoshi Department of Urology, Ehime University Graduate School of Medicine, Shitsukawa, 791-0295, Toon, Ehime, Japan aut International Journal of Clinical Oncology Springer Japan 20/5(2015-10-01), 1042-1047 1341-9625 20:5<1042 2015 20 10147 https://doi.org/10.1007/s10147-015-0817-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10147-015-0817-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Asai Seiji Department of Urology, Ehime University Graduate School of Medicine, Shitsukawa, 791-0295, Toon, Ehime, Japan aut NATIONALLICENCE 700 1- Fukumoto Tetsuya Department of Urology, Ehime University Graduate School of Medicine, Shitsukawa, 791-0295, Toon, Ehime, Japan aut NATIONALLICENCE 700 1- Tanji Nozomu Department of Urology, Ehime University Graduate School of Medicine, Shitsukawa, 791-0295, Toon, Ehime, Japan aut NATIONALLICENCE 700 1- Miura Noriyoshi Department of Urology, Ehime University Graduate School of Medicine, Shitsukawa, 791-0295, Toon, Ehime, Japan aut NATIONALLICENCE 700 1- Miyagawa Masao Department of Diagnostic and Therapeutic Radiology, Ehime University Graduate School of Medicine, 791-0295, Toon, Ehime, Japan aut NATIONALLICENCE 700 1- Nishimura Kenichi Department of Urology, Ehime University Graduate School of Medicine, Shitsukawa, 791-0295, Toon, Ehime, Japan aut NATIONALLICENCE 700 1- Yanagihara Yutaka Department of Urology, Ehime University Graduate School of Medicine, Shitsukawa, 791-0295, Toon, Ehime, Japan aut NATIONALLICENCE 700 1- Shirato Akitomi Department of Urology, Ehime University Graduate School of Medicine, Shitsukawa, 791-0295, Toon, Ehime, Japan aut NATIONALLICENCE 700 1- Miyauchi Yuki Department of Urology, Ehime University Graduate School of Medicine, Shitsukawa, 791-0295, Toon, Ehime, Japan aut NATIONALLICENCE 700 1- Kikugawa Tadahiko Department of Urology, Ehime University Graduate School of Medicine, Shitsukawa, 791-0295, Toon, Ehime, Japan aut NATIONALLICENCE 700 1- Yokoyama Masayoshi Department of Urology, Ehime University Graduate School of Medicine, Shitsukawa, 791-0295, Toon, Ehime, Japan aut NATIONALLICENCE 773 0- International Journal of Clinical Oncology Springer Japan 20/5(2015-10-01), 1042-1047 1341-9625 20:5<1042 2015 20 10147